Synthesis and Characterisation of Starch Glutamate as a Novel Superdisintegrant

Authors

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed to be University)
  • Sahithi Mudili GITAM Institute of Pharmacy, GITAM (Deemed to be university), Rushikonda, Visakhapatnam, A.P 530045, INDIA

Abstract

Superdisintegrants have been developed to improve the disintegration process of the fast dissolving tablets. Superdisintegrants acts as structural weakner in fast dissolving tablets and helps in the quick breakup of the tablet into small particles. A new novel superdisintegrant starch glutamate has been synthesized by esterification process and characterized by the FTIR, X-ray diffraction and scanning electron microscopy. Starch glutamate physical and micromeritics properties have been evaluated.The prepared starch glutamate was in soluble in aqueous buffers, organic and in-organic solvents tested. It was free flowing, amorphous in nature, having good swelling index, excellent flow property. The swelling index of starch glutamate was found to be 1200 indicating the suitability of starch glutamate as superdisintegrant in the formulation of fast dissolving dosage forms.

Keywords: Superdisintegrants, Starch glutamate, Swelling index.

DOI

https://doi.org/10.22270/jddt.v9i4.3147

Author Biographies

Rada Santosh Kumar, GITAM Institute of Pharmacy, GITAM (Deemed to be University)

GITAM Institute of Pharmacy, GITAM (Deemed to be university), Rushikonda, Visakhapatnam, A.P 530045, INDIA

Sahithi Mudili, GITAM Institute of Pharmacy, GITAM (Deemed to be university), Rushikonda, Visakhapatnam, A.P 530045, INDIA

GITAM Institute of Pharmacy, GITAM (Deemed to be university), Rushikonda, Visakhapatnam, A.P 530045, INDIA

Published

2019-07-07
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How to Cite

1.
Santosh Kumar R, Mudili S. Synthesis and Characterisation of Starch Glutamate as a Novel Superdisintegrant. J. Drug Delivery Ther. [Internet]. 2019 Jul. 7 [cited 2026 Jan. 22];9(4):100-3. Available from: https://jddtonline.info/index.php/jddt/article/view/3147

Issue

Vol. 9 No. 4 (2019): Volume 9, Issue 4, July-August 2019

Section

Research

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How to Cite

1.
Santosh Kumar R, Mudili S. Synthesis and Characterisation of Starch Glutamate as a Novel Superdisintegrant. J. Drug Delivery Ther. [Internet]. 2019 Jul. 7 [cited 2026 Jan. 22];9(4):100-3. Available from: https://jddtonline.info/index.php/jddt/article/view/3147
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