INNOVATIVE GROWTH IN DEVELOPING NEW METHODS FOR FORMULATING SOLID LIPID NANOPARTICLES AND MICROPARTICLES

Abstract

The solid lipid nanopaticles are the colloidal drug delivery system which is spherical in shape and present in 10-1000nm particle sized range. The surfactant is used to stabilize the solid lipid nanoparticles to avoid aggregation. The Co-surfactant was used in addition to increase the micelles concentration. The optimization of surfactant concentration was used to stabilize the nanoparticles and microparticles formed and to decrease the particle size by decrease the aggregation. The manufacturing methods of the SLN are of four types, the high pressure homogenization which is further divides into two types hot homogenization method and cold homogenization method, Solvent-Diffusion evaporation method, ultrasonication method, and membrane contactor method. The non-uniform particles sizes were obtained from high pressure and ultra-sonication methods but the solvent-Diffusion Evaporation method and membrane contactor methods give uniform sized particles. But disadvantages of the later methods are the toxicity of organic solvent if not evaporates completely from the SLNs and the high cost of membrane contactor instrument is there in the formulation of SLNs. While the ultra-turrax and high pressure homogenization methods are the safest methods to use as compared to Solvent-Diffusion Evaporation method. The unpublished results have indicated that the drug release from the HPH and ultra-sonication gave highest drug release as compared to marketed conventional gel and formulation obtained by Solvent-Diffusion Evaporation method.

Keywords: SLN, high pressure homogenization method, Solvent-Diffusion Evaporation method, ultrasonication method, Membrane contactor method