PARTICLE SIZE REDUCTION OF ACECLOFENAC BY USING SURFACTANTS AND MICRONIZATION FOR NANOCARRIER ENTRAPMENT

Abstract

The Aceclofenac (2-[(2, 6- dichlorophenyl) amine] phenylacetoxyacetic acid) is a Non-Steroidal Anti-Inflammatory category of drug, which is water insoluble drug of BCS class-II which has low solubility and high permeability phenomenon. The particle size reduction technique is used to solubilize the aceclofenac. The particle size of aceclofenac in bulk form is 140-200 microns. In this experiment, The 35 microns particle size was reduced in powder form from 140-200 microns by using Air jet mill and 17.08 microns size was reduced by using dynomill and 33.62 microns particle size was reduced by using Tween 80 as surfactant as considered as lowest particle size. The Labrasol and Na. CMC were also used in this experiment. The equipments used to reduce particle size of aceclofenac are ultra-Turrax (Ultra-sonication), Air jet mill and Dynomill. These all instruments used to reduce the particle size of aceclofenac are safe and not any chemical compound was added in any of the method described above. This study was used to see the uniform nature of the nano- and micro-particles entrapping the aceclofenac drug obtained by High shear homogenization, high pressure homogenization, Solvent-Diffusion evaporation and membrane contactor methods. If the particle size of aceclofenac cannot be reduced less than 14 microns then at the time of Permeation studies the same particle size will enter in Stratum corneum of Skin and entrapped in the carrier matrix. And formation of microns sized particles will obtained while preparing Solid lipid nanoparticles.

Keywords: Solubilization, Particle size reduction, Air jet mill, high shear homogenizer, particle size analyzer, Dynomill