ELASTIC LIPOSOME MEDIATED TRANSDERMAL DELIVERY OF AN ANTI-HYPERTENSIVE AGENT: NIFEDIPINE
Abstract
In the present investigation elastic liposomes of nifedipine were prepared for transdermal delivery. Elastic liposomes bearing nifedipine were prepared by rotary evaporation method and characterized for various parameters including vesicles shape, size and size distribution, entrapment efficiency, number of vesicles, and stability. Then entrapment efficiency of different compositions of elastic liposomal formulations was carried out, through which one formulation was selected for the further parameters. Higher entrapment efficiency was found in transferosomal formulaton which was more than liposomal formulation. Also similar trend was observed in number of vesicles present in elastic liposomal formulation were also more than liposomal formulation. The in vitro drug release study was carried out in modified Diffusion cell using Dialysis membrane. The release rate of nifedipine from elastic liposomes was significantly lower than liposomes. Ex-vivo study conducted on male albino rats (Sprague Dawley) was also taken as a measure of performance of elastic liposomal and liposomal solution. Skin study showed that elastic liposomal formulation provides higher skin permeation as compared to liposomal solution of nifedipine. (elastic liposome 76.41±0.9,  liposome 71.44±0.9) Stability studies showed that there was no change in consistency of elastic liposomal formulation and also drug crystals were not appeared. Hence, the present study reveals that elastic liposomal formulation of nifedipine possesses greater potential to enhance skin permeation, prolong drug release, and improve the site-specificity of nifedipine.
Keyword’s- nifedipine. elastic liposomes, Transdermal delivery, stability
DOI
https://doi.org/10.22270/jddt.v2i5.278
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