Design, optimization and evaluation of ibuprofen fast dissolving tablets employing starch tartrate: A new superdisintegrant
Abstract
The current scenario deals with the study of fast dissolving tablets for the patients suffering from swallowing, sickness ,etc. The present investigation involves in the evaluation of starch tartrate as a superdintegrant in the formulation of fast dissolving tablets of poorly soluble drugs employing 23factorial design. Starch tartrate was synthesized by esterification process. The synthesized starch tartrate was subjected to physical and micromeritic evaluation. All fast dissolving tablets were evaluated for drug content, hardness, friability, disintegration time and other dissolution characteristics like percent dissolved in 5 min (PD5), dissolution efficiency in 5 min (DE5%) and first order rate constant(K1). The starch tartrate prepared was found to be fine, free flowing slightly crystalline powder. Starch tartrate exhibited good swelling in water.Fourier transform infrared spectra (FTIR) and Differential scanning calorimetry (DSC) study indicated the absence of interaction between ibuprofen and starch tartrate. All the fast dissolving tablets formulated employing starch tartrate were of good quality with regard to drug content (200±5%), hardness (3.6–3.9 kg/sq. cm), and friability (0.12-0.15%). The optimised formulation F2 has the least disintegration time i.e., 9±0. 03s. The in–vitro wetting time was less (i.e., 60s) in optimized formulation F2. The water absorption ratio of the formulated tablets was found to be in the range of 27.53±0.12 to 69.75±0.18%. The cumulative drug dissolved in the optimized formulation F2 was found to be 100.17±0.56% in 5 min. Starch tartrate was found to be a superdisintegrant which enhanced the dissolution efficiency with the ibuprofen and hence it could be used in the formulation of fast dissolving tablets to bring immediate release of the contained drug within 5 minutes.
Keywords: Fast dissolving, Superdisintegrant, Starch tartrate, Dissolution efficiency.
DOI
https://doi.org/10.22270/jddt.v9i2.2534References
Suresh B, Rajender KM, Ramesh G, Yamsani MR. Orodispersible tablets: An overview. Asian J Pharm 2008; 2:2-11.
Seager H. Drug delivery product and zydis-fast dissolving dosage form. J Pharm Pharmacol 1998; 50:375-82.
Abdelbary G, Prinderre P, Couani C, Taochim J, Reynier JP, Riccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm 2004; 278:423-33.
Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery: a review. Pharm Sci Techol Today 2000; 3:138-45.
Lachman L, Libermann HA, Kanig JL. The theory and practice of industrial pharmacy. 3rdedition; 1991. p. 233-5.
Biradar S, Bhagavati S, Kuppasad I. Fast dissolving drug delivery system: A brief overview. Internet J Pharmacol 2005;4:2. edition; 1991. p. 233-5.
Indurwade NH, Rajyaguru TH, Nakhat PD. Noval approach-fast dissolving tablets. Indian Drug 2002; 38:405-9.
The United States Pharmacopoeia 29, National Formulary 24, Asian Edition. Rockville, MD: United States Pharmacopoeia Convention, Inc; 2006. p. 1890.
Jacob S, Shirwaikar A, Joseph A, Srinivasan KK. Novel co-processed excipient of mannitol and microcrystalline callous for preparing fast dissolving tablet of Glipizide. Indian J Pharm Sci 2007: 69:633-9.
Hiremath JG, Shastry CS, Srinath MS. Pharmaceutical approaches of taste masking in oral dorage forms. Indian Drugs 2004; 41:253-7.
Abdelbary A, Elshafeey AH, Zidan G. Comparative effects of different cellulosic-based directly compressed orodispersible tablets on oral bioavailability of famotidine. Carbohydrate Polymers 2009; 77:799-806.
Battu SK, Michael AR, Soumyajit M, Madhusudan Y. Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of super disintegrants. Drug Dev Ind Pharm 2007; 33:1225-32.
Goel H, Vora N, Rana V. A novel approach to optimize and formulate fast disintegrating tablets for nausea and vomiting. AAPS PharmSciTech 2008; 9:774–8.
Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV. Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. J King Saud University (Sci) 2010; 22:229–40.
Sai Kishore V, Gowtham Kumar D, Sudheer B, Sandeep M. Design and development of fast dissolving tablets of ibuprofen.Res Rev Pharm Pharm Sci 2013; 2:65-71.
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