FORMULATION AND EVALUATION OF TABLETS CONTAINING ARTEMETHER MICROSPHERES AND LUMEFANTRINE
Abstract
This study was aimed to fabricate and evaluate a combination of Artemether and Lumefantrine as tablets and to make Artemether in sustained form so as to prolong its elimination time. Artemether was formulated in form of microspheres by solvent evaporation technique and was then formed into the tablet along with the Lumefantrine. Artemether microspheres were prepared and compressed into compressible tablet by direct compression process using the compressible excipients along with Lumefantrine, and was further evaluated for various parameters such as hardness, thickness, weight variation, friability, drug content, in vitro drug release and stability.
DOI
https://doi.org/10.22270/jddt.v7i7.1569References
Aboghanem A, Alburyhi M, Alwan A, Effect of different excipients on formulation of immediate release Artemether/Lumefantrine tablets, J Chem Pharm Res, 2013, 5, 617-625.
Alagusundaram M, Chetty M, Umashankar K, Badarinath A, Ramkanth S, Microspheres as a novel drug delivery system, Int J Chem Tech Res, 2009, 1, 526-534.
Aulton, ME, Pharmaceutics: The Science of Dosage Form Design, in: Wells, J., Second edition, Pharmaceutical preformulation: the physicochemical properties of drug substances. Churhill Livingstone, Leicester, 2002, 114-136.
Balaji A, Kumari H, Kumar U, Development, characterization and evaluation of solid dispersions of artemether and lumefantrine by solvent evaporation method using hydrophilic polymers, Int J Pharn Pharm Sci, 2014, 4, 180-185.
Bannister LH, Sherman IW, Plasmodium. Encyclopedia of Life Sciences John Wiley & Sons, 2009, 26:1-10.
Published
Abstract Display: 1007 
PDF Downloads: 794 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.