Quercetin Exerts Anti-convulsant Effects in Animal Model of Grand Mal Epilepsy: Modulation of GABA and Glycinergic Pathways

Authors

  • Gaurav Parihar IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Bhubharti Dehariya IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Santosh Ghule IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Pankaj Dixit IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Neelam Balekar IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Abstract

Quercetin is low molecular weight flavonoid having multiple neuropharmacological actions. Recently, its anticonvulsant effect was reported in rats using electrical kindling models. However, earlier cell culture studies have documented antagonistic action of quercetin on GABAA, GABAC and Glycine channels, which is contrary to recent findings. Hence, the present study aimed at characterizing the effects of quercetin administration in various experimental models of epilepsy. Dose-dependent effects of quercetin on maximal-electroshock seizure (MES) were determined. Further, the effective dose was tested in pentylenetetrazol-induced seizures (PTZ), and strychnine-induced seizures to study the involvement of GABA and Glycinergic receptors. The results revealed a potent anticonvulsant effect of quercetin in MES induced seizures at a dose of 5 and 10 mg/kg. This effect was found to be retained in case of PTZ-induced convulsions and strychnine-induced convulsions (quercetin 10 mg/kg). The present finding warrants further substantiation along with their correlation to molecular mechanism of action.

DOI

https://doi.org/10.22270/jddt.v7i7.1633

Author Biographies

Gaurav Parihar, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Bhubharti Dehariya, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Santosh Ghule, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Pankaj Dixit, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Neelam Balekar, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

References

Nitsinskaya LE, Ekimova IV, Guzhova IV, Feizulaev BA, Pastukhov YuF, Effects of quercetin on the severity of chemically induced convulsions and 70-kDal heat shock protein content in brain structures in rats, Neurosci Behav Physiol, 2011, 41(7), 1-7.

Sun H, Cheng XP, Ye ZY, Jiang P, Zhou JN, quercetin subunit specifically reduces GLYR mediated Current in rat, HNN, 2007, 148, 548–559.

Goutman JD, Calvo DJ, Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABAÏ1 receptor, BJP, 2004, 141 (4) 717-727.

Kaushik D, Tripathi A, Tripathi R, Ganachari M, Khan SA, Anticonvulsant activity of Bacopa monniera in rodents, BJPS, 2009, 45(4), 1-6.

Bhosale UA, Yegnanarayan R, Pophale PD, Zambare MR, Somani RS Study of central nervous system depressant and behavioral activity of an ethanol extract of Achyranthes aspera (Agadha) in different animal models, Int J Appl Basic Med Res, 2011, 1(2), 104-108.

Published

22-12-2017
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How to Cite

1.
Parihar G, Dehariya B, Ghule S, Dixit P, Balekar N. Quercetin Exerts Anti-convulsant Effects in Animal Model of Grand Mal Epilepsy: Modulation of GABA and Glycinergic Pathways. J. Drug Delivery Ther. [Internet]. 2017 Dec. 22 [cited 2025 Feb. 11];7(7):194-6. Available from: https://jddtonline.info/index.php/jddt/article/view/1633

How to Cite

1.
Parihar G, Dehariya B, Ghule S, Dixit P, Balekar N. Quercetin Exerts Anti-convulsant Effects in Animal Model of Grand Mal Epilepsy: Modulation of GABA and Glycinergic Pathways. J. Drug Delivery Ther. [Internet]. 2017 Dec. 22 [cited 2025 Feb. 11];7(7):194-6. Available from: https://jddtonline.info/index.php/jddt/article/view/1633