DESIGN AND EVALUATION OF EXTENDED RELEASE CEFUROXIME AXETIL FLOATING TABLETS WITH IMPROVED GI ABSORPTION
Abstract
Oral drug delivery system represents one of the frontier area of controlled drug delivery system. Floating drug delivery system belongs to oral controlled drug delivery system group, which is capable of floating in the stomach for prolong period of time. The objective of the present research work is to provide a gastroretentive system for sustained release of therapeutically active agent, cefuroxime axetil in upper part of gastro-intestinal tract in the form of floating tablet. Cefuroxime axetil, an oral prodrug shows a bioavailablity of 30% to 40% when taken on fasting and 5% to 60% whentaken after food. The cefuroxim axetil esterase can hydrolyze cefuroximeaxetil to the nonabsorbable cefuroxim in the gut lumen and is therefore, suspected as a possible cause of incomplete bioavailability. Which suggests an absorption mechanism through the mucosa with limited capacity. Cefuroxime axetil had saturation kinetics that could be overcome by slow release of drug from the formulation, by incorporating cefuroxime axetil in sustained drug delivery system.
Keywords: Floating drug delivery system, Cefuroxime axetil, Gastro-intestinal tract
Â
DOI
https://doi.org/10.22270/jddt.v7i1.1352References
Chawla G, Gupta P, Bansal AK.Gastroretentivedrug deliverysystems. In: Jain NK, editor. Progress in controlled and noveldrug delivery system. 1sted.New Delhi (India): CBS Publishers and Distributors; 2004. p. 76-97.
Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drugdeliverysystems:AReview.AAPS PharmSciTech 2005;6: Article 47.
Vyas SP, and KharRK.eds. Controlled Drug Delivery Concept And Advances. New Delhi:Vallabh Prakashan.1stedition 2000:1, 54,155,196
Arora S, Javed A, Ahuja A, Khar RK, Baboota S. Floating drug delivery system: A review. AAPS PharmSciTech. 2005;6:Article47
Indian Pharmacopoeia. Government of India. Ministry of Health and Family Welfare. Vol. II Delhi: Controller of Publications. 1996.
Shinde A.J.,Patil M. S.,More H.N., MoreFormulation and Evaluation of an Oral Floating Tablet of Cephalexin,Indian J.Pharm. Educ. Res. 44(3), Jul-Sep, 20
Narendra C, Srinath MS, Ganesh B. Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention. AAPS PharmSciTech 2006;7(2):Article 34
Prajapati ST, Patel LD, Patel DM.Gastric floating matrix tablets: Design and optimization using combination of polymers. Acta Pharm 2008; 58:221–229.
Tokumura T., Machida Y., Preparation of amoxicillin intragastric buoyant sustained-release tablets and the dissolution characteristics, Journal of Controlled Release 110 (2006) 581 – 586
Chavanpatil M, Jain P, Chaudhari S, Shear R, Vavia P. Novel sustained release, swellable and bioadhesivegastroretentive drug delivery system for ofloxacin.Int J Pharm 2005;304:178 184.
Arza RA, Gonugunta CS, Veerareddy PR. Formulation and evaluation of floating gastroretentive ciprofloxacin hydrochloride tablets. AAPS PharmSciTech 2009 March;10(1):220-226
Patel A, Ray S, Thakur S. In-vitro evaluation and optimization of controlled release floating drug delivery system of metformin hydrochloride. DARU 2006; 14(2):57-64
KawashimaY,TakeuchiH,YamamotoH.Gastrointestinalretentivemicroparticulatesystemtoimprove oral drug delivery. In: Wise DL, editor. Handbook of pharmaceutical controlledrelease technology. New York: Marcell Dekker Inc; 2000. P. 505-25.
Fabregas JL, Claramunt J, Cucala J, Pous R, Siles A. In vitro testing of an antacid formulation with prolonged gastric residence time (Almagateflot coat). Drug DevInd Pharm 1994;20:1199– 1212.
Liu S, Wang N, Liu R. Oral modified release drug delivery for water insoluble drugs. In: Liu R, editor. Water insoluble drug formulation, 2nd ed. Boka Raton (FL): CRC press; 2008. p. 609-32.
Loganathan V, Saravanakumar T, Bhojwani A, Mullaichavam A, Nandgude T. Formulation, development and evaluation of Ofloxacin containing floating drug delivery system. Asian J Pharm 2006; 1:22-24.
Chen J, Blevins WE, Park H, Park K. Gastric retention properties of superporous hydrogel composites. J Control Rel 2000;64(1-3):39–51
Sharma S, Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm 2006; 313:150-58.
Loganathan V, Saravanakumar T, Bhojwani A, Mullaichavam A, Nandgude T. Formulation, development and evaluation of Ofloxacin containing floating drug delivery system. Asian J Pharm 2006;1:22-24Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air. J Pharm Sci 1983; 72:1189-91.
Gander B, Gurny R, Doelker E. Matrices for controlled liberation of drugs from polymers. Pharm ActaHelv 1986; 61:130-34.
Doelker E, Peppas NA, editors. Hydrogels in Medicine and Pharmacy. Boca Raton (FL): CRC Press Inc; 1987. p. 115-160.
R.K.,MohapatraS.,DashR.K.BarikB.B.,Preparation and in vitro charachterizationofCefuroximeaxetil Floating tablet. Drug Invention Today 2010, 2(10),457-459
Sangekar S, Vadino WA, Chaudry I, Parr A, Behin R, Digenis G. Evaluation of effect of food and specific gravity on tablets on gastric retention time. Int J Pharm 1987; 35:187-191.
Baumgartner S, Kristel J, Vreer F, Vodopivec P, Zorko B. Optimisation of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000; 195:125-135
Chavanpatil M, Jain P, Chaudhari S, Shear R, Vavia P. Development of sustained release gastroretentive drug delivery system for ofloxacin: In-vitro and in-vivo evaluation. Int J Pharm. 2005;304:178–184
Colombo P, Santi P, Bettini R, Brazel CS, Peppas NA. Drug release from swelling-controlled system. In: Wise DL, editor. Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker Inc; 2000. p. 183-209.
Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air. J Pharm Sci 1983;72:1189-91
Published
Abstract Display: 628 
PDF Downloads: 684 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.