EVALUATION AND CHARACTERIZATION OF TRANSDERMAL THERAPEUTIC SYSTEMS: AN EXHAUSTIVE PICTORIAL AND FIGURATIVE REVIEW
Designing and development of transdermal patches can be described as state of the art. The development of Transdermal drug delivery system is multidisciplinary activity that encompasses fundamental feasibility studies starting from the selection of drug molecule to the demonstration of sufficient drug flux in an ex vivo and in vivo model followed by fabrication of a drug delivery system that meets all the stringent needs that are specific to the drug molecule (physicochemical and stability factors), the patient (comfort and cosmetic appeal), the manufacturer (scale up and manufacturability) and most important the economy. The assessment of the performance of transdermal therapeutic devices designed for controlled drug release may result in a complex analytical issue and multidisciplinary studies focused on the evaluation of physicochemical, morphological and textural properties of the products may be required.Â This paper presents a review of transdermally applied formulations with emphasis on the evaluation of patches in a wide variety of evaluation parameters such as Physico-chemical evaluation, Adhesive evaluation, Skin irritation test, In-vitro, Ex-vivo, In-vivo techniques using animal models and human skin and Accelerated stability studies.
Keywords: Transdermal patches, Physico-chemical evaluation, Adhesive evaluation, Skin irritation test, In-vitro, Ex-vivo and In-vivo techniques, Accelerated stability studies.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).