SUPERDISINTEGRANTS- CURRENT APPROACH

Abstract

ABSTRACT

The  desire  of  improved  palatability  in  orally  administered  products  has  prompted  the  development  of  numerous formulations with improved performance and acceptability. Orally disintegrating tablets are an emerging trend in novel drug  delivery  system  and  have received  ever-increasing  demand  during  the  last  few  decades.    This  is  achieved  by  decreasing  the  disintegration  time  which  in turn  enhances  drug  dissolution  rate.  Disintegrants  are  substances  or  mixture  of  substances  added  to the  drug  formulation that  facilitates  the  breakup  or  disintegration  of  tablet  or  capsule  content  into  smaller  particles  that  dissolve  more rapidly. Superdisintegrants are used to improve the efficacy of solid dosage forms. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1- 10 % by weight relative to the total weight of the dosage unit. Diverse  categories  of  Superdisintegrants  such  as  synthetic,  semi-synthetic,  natural  and  co-processed  blends  etc.  have  been  employed  to  develop  effectual  mouth  dissolving  tablets  and  to  overcome  the limitations of conventional  tablet dosage form. The  present  study  describes the various  types  of  Superdisintegrants  which  are  being  used  in  the  formulation  to  provide  the  safer, effective  drug delivery with patient's compliance.