Nanotechnology-Driven Drug Delivery System: Recent Advances, Applications and Future Perspectives
Abstract
Purpose: With the ability to solve problems of standard medicine, nanotechnology is presently an innovative technology in advanced pharmaceutical delivery. A wide range of nanocarriers, including lipid-based systems, polymeric nanoparticles, self-assembled structures, and functionalized nanomaterials, provides diverse platforms for the delivery of a range of medicaments, extending from pure substances to genetic therapies like siRNA 4.
Methods: This review highlights the application of nanotechnology-based systems in drug delivery, including their role in tumour research, bronchial delivery, oral therapeutic formulations, and even integrated techniques such as diagnostic-guided therapy, which blends the assessment and cure.
Results: By presenting the accurate transfer and managed release, nanoparticles can strengthen the therapeutic solubility, durability, and uptake while facilitating the therapeutic results and minimizing the side effects2,3.An additional benchmark has been given to Antitumor therapy, where site-specific nanoparticles and reaction-prone system reduce the harm to nourishing cells while strengthening the treatment reproducibility3,8. Green and sustainable nanomaterials focus on the advancement towards reliable, planet-friendly, and user-friendly formulations5.
Conclusion: Regardless of these new methods, hardships remain in assuring large-batch production, prolonged safety, loss prevention, and sandardization approval6. Currently, investigation prevails to more evident technological approaches, plan efficient carriers, and analyse future opportunities where nano-drug delivery could alter the healthcare on an international scale7 .
Keywords: nanocarriers, bioavailability, diagnostic-guided therapy, targeted delivery, novel drug delivery system.
Keywords:
Bioavailability, Novel Drug Delivery, Nanotechnology, nanocarrier, targeted delivery, diagnostic-guided therapyDOI
https://doi.org/10.22270/jddt.v16i4.7694References
1. Davis ME, Chen ZG, Shin DM. Nanoparticle therapy: An emerging treatment modality for cancer. Nature Reviews Drug Discovery. 2008;7(9):771-782. https://doi.org/10.1038/nrd2614 PMid:18758474 PMCid:PMC11750695
2. Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nanomedicines. 2009;3(1):16-20. https://doi.org/10.1021/nn900002m PMid:19206243
3. Zhang L, Gu FX, Chan JM, Wang AZ, Langer R, Farokhzad OC. Nanoparticles in medicine: Therapeutic application and developments. Clinical pharmacology and therapeutics. 2008;83(5):761-769. https://doi.org/10.1038/sj.clpt.6100400 PMid:17957183
4. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nature Nanotechnology. 2007;2(12):751-760. https://doi.org/10.1038/nnano.2007.387 PMid:18654426
5. Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicines: Progress, challenges and opportunities. Nature Reviews Cancer. 2017;17(1):20-37. https://doi.org/10.1038/nrc.2016.108 PMid:27834398 PMCid:PMC5575742
6. Patra JK, Das G, Fraceto LF, et al. Nano-based drug delivery systems: Recent developments and future prospects. Journal of Nanobiotechnology. 2018;16(1):1-33. https://doi.org/10.1186/s12951-018-0392-8 PMid:30231877 PMCid:PMC6145203
7. Etheridge ML, Campbell SA, Erdman AG, Haynes CL, Wolf SM, McCullough J. The picture on nanomedicine: The state of investigational and approved nanomedicine products. Nanomedicine. 2013;9(1):1-14. https://doi.org/10.1016/j.nano.2012.05.013 PMid:22684017 PMCid:PMC4467093
8. Sethi V, Kumar P, Ali M. Limitations of conventional delivery systems. Pharmaceutics . 2020;12(5):1-10.
9. Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V. PLGA-based nanoparticles: An overview of biomedical applications. Journal of Controlled Release. 2012;161(2):505-522. https://doi.org/10.1016/j.jconrel.2012.01.043 PMid:22353619
10. Blanco E, Shen H, Ferrari M. Principles of nanoparticles design for overcoming biological barriers to drug delivery. Nature Biotechnology. 2015;33(9):941-951. https://doi.org/10.1038/nbt.3330 PMid:26348965 PMCid:PMC4978509
11. Srujana S, Anjamma M, Alimuddin, Singh B, Dhakar RC, Natarajan S, Hechhu R. A Comprehensive Study on the Synthesis and Characterization of TiO2 Nanoparticles Using Aloe vera Plant Extract and Their Photocatalytic Activity against MB Dye. Adsorption Science & Technology. 2022;2022 https://doi.org/10.1155/2022/7244006
12. Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications and toxicities. Arabian Journal of Chemistry. 2019;12(7):908-931. https://doi.org/10.1016/j.arabjc.2017.05.011
13. Langer R. Drug delivery and targeting. Nature. 1998;392:5-10. https://doi.org/10.1038/32020
14. Allen TM, Cullis PR. Liposomal drug delivery systems: From concept to clinical applications. Advanced Drug Delivery Reviews. 2013;65(1):36-48. https://doi.org/10.1016/j.addr.2012.09.037 PMid:23036225 PMCid:PMC10539472
15. Torchilin VP. Multifunctional nanocarriers. Nature Reviews Drug Discovery. 2014;13(11):813-827. https://doi.org/10.1038/nrd4333 PMid:25287120 PMCid:PMC4489143
16. Shi Y, Lammers T. Combining nanomedicine and immunotherapy. Nature Reviews Drug Discovery. 2019;18:673-684.
17. Saraiva C, Praca C, Ferreira R, Santos T, Ferreira L, Bernardino L. Nanoparticle-mediated brain drug delivery. Journal of Controlled Release. 2016;235:34-47. https://doi.org/10.1016/j.jconrel.2016.05.044 PMid:27208862
18. Begines B, Ortiz T, Perez-Aranda M, Martinez G, Merinero M, Argüelles-Arias A. Polymeric nanoparticles for drug delivery: Recent developments and prospects. Nanomaterials. 2020;10(7):1403. https://doi.org/10.3390/nano10071403 PMid:32707641 PMCid:PMC7408012
19. Singh R, Lillard JW. Nanoparticle-based targeted drug delivery. Experimental and Molecular Pathology. 2009;86(3):215-223. https://doi.org/10.1016/j.yexmp.2008.12.004 PMid:19186176 PMCid:PMC3249419
20. Allen TM, Cullis PR. Drug delivery systems: Entering the mainstream. Science. 2004;303(5665):1818-1822. https://doi.org/10.1126/science.1095833 PMid:15031496
21. Petros RA, DeSimone JM. Strategies in the design of nanoparticles. Nature Reviews Drug Discovery. 2010;9(8):615-627. https://doi.org/10.1038/nrd2591 PMid:20616808
22. Danhier F, Feron O, Préat V. To exploit the tumour microenvironment: Passive and active tumour targeting of nanocarriers for anti-cancer drug delivery. Journal of Controlled Release. 2010;148(2):135-146. https://doi.org/10.1016/j.jconrel.2010.08.027 PMid:20797419
23. Gaitanis A, Staal S. Liposomal doxorubicin and nab-paclitaxel: Nanoparticle cancer chemotherapy in current clinical use. Methods in Molecular Biology. 2010;624:385-392. https://doi.org/10.1007/978-1-60761-609-2_26 PMid:20217610
24. Wohlfart S, Gelperina S, Kreuter J. Transport of drugs across the blood-brain barrier by nanoparticles. Journal of Controlled Release. 2012;161(2):264-273. https://doi.org/10.1016/j.jconrel.2011.08.017 PMid:21872624
25. Kreuter J. Nanoparticles - A historical perspective. International Journal of Pharmaceutics. 2007;331(1):1-10. https://doi.org/10.1016/j.ijpharm.2006.10.021 PMid:17110063
26. Gulyaev AE, Gelperina SE, Skidan IN, Antropov AS, Kivman GY, Kreuter J. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharmaceutical Research. 1999;16(10):1564-1569. https://doi.org/10.1023/A:1018983904537 PMid:10554098
27. Kaur IP, Bhandari R, Bhandari S, Kakkar V. Potential of solid lipid nanoparticles in brain targeting. Journal of Controlled Release. 2008;127(2):97-109. https://doi.org/10.1016/j.jconrel.2007.12.018 PMid:18313785
28. Wang AZ, Langer R, Farokhzad OC. Nanoparticle Delivery of Cancer Drugs. Annual Review of Medicine. 2012;63:184-198. https://doi.org/10.1146/annurev-med-040210-162544 PMid:21888516 PMCid:PMC10539472
29. Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nature Reviews Genetics. 2014;15(8):541-555. https://doi.org/10.1038/nrg3763 PMid:25022906
30. Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnology Advances. 2009;27(1):76-83. https://doi.org/10.1016/j.biotechadv.2008.09.002 PMid:18854209 PMCid:PMC10300527
31. Pelgrift RY, Friedman AJ. Nanotechnology as a therapeutic tool to combat microbial resistance. Advanced Drug Delivery Reviews. 2013;65(13-14):1803-1815. https://doi.org/10.1016/j.addr.2013.07.011 PMid:23892192 PMCid:PMC10475466
32. Qi L, Xu Z, Jiang X, Hu C, Zou X. Preparation and antibacterial activity of chitosan nanoparticles. Carbohydrate Research. 2004;339(16):2693-2700. https://doi.org/10.1016/j.carres.2004.09.007 PMid:15519328
33. Samad, Sultana Y, Aqil M. Liposomal drug delivery systems: An update review. Current Drug Delivery. 2007;4(4):297-305. https://doi.org/10.2174/156720107782151269 PMid:17979650
34. Bobo D, Robinson KJ, Islam J, Thurecht KJ, Corrie SR. Nanoparticle-based medicines: A review of FDA-approved materials and clinical trials to date. Pharmaceutical Research. 2016;33(10):2373-2387. https://doi.org/10.1007/s11095-016-1958-5 PMid:27299311
35. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery. 2021;20(2):101-124. https://doi.org/10.1038/s41573-020-0090-8 PMid:33277608 PMCid:PMC7717100
36. Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nature Materials. 2013;12(11):991-1003. https://doi.org/10.1038/nmat3776 PMid:24150417
37. Rwei AY, Wang W, Kohane DS. Photoresponsive nanoparticles for drug delivery. Nano Today. 2013;10(4):451-467. https://doi.org/10.1016/j.nantod.2015.06.004 PMid:26644797 PMCid:PMC4669578
38. Svensson E, Shen H, Kanje M, Östman K, Löfblom J, Linse S. Achieving precision healthcare through nanomedicine and advanced drug delivery systems. ACS Material Au. 2023;3(6):546-579.
39. Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nature Biotechnology. 2015;33(9):941-951. https://doi.org/10.1038/nbt.3330 PMid:26348965 PMCid:PMC4978509
40. Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622-627. https://doi.org/10.1126/science.1114397 PMid:16456071
41. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: An emerging discipline. Environmental Health Perspectives. 2005;113(7):823-839. https://doi.org/10.1289/ehp.7339 PMid:16002369 PMCid:PMC1257642
42. Ventola CL. The nanomedicine revolution. Pharmacy and Therapeutics. 2012;37(9):512-525. https://doi.org/10.1111/j.1365-2710.2012.01347.x PMid:22462645
Published
Abstract Display: 119
PDF Downloads: 49
PDF Downloads: 2 How to Cite
Issue
Section
Copyright (c) 2026 Manisha Chandola , Karuna Dhaundhiyal , Abhijeet Ojha , Arun Kumar Singh , Vikas Bhatt

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

.