SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM- A NOVALAPPROACH FOR IMPROVING BIOAVAILABILITY
Abstract
The primary object of self-nanoemulsifying drug delivery system (SNEDDS) is to enhance the oral bioavailability of poorly water soluble drugs.The major problem in oral formulations is low and erratic bioavailability, which mainly results due to poor aqueous solubility of active constituents. Among various approach SNEDDS has gained more attention due to enhanced oral bio-availability enabling reduction in dose. Nano-emulsions can be easily fabricated by low-energy emulsification methods, such as the phase inversion ,temperature method and phase inversion composition method. SNEDDS are anhydrous homogenous liquid mixtures consisting of oil, surfactant, drug and co-emulsifier or solubilizer, which spontaneously form oil-in-water nanoemulsion of approximately 200 nm or less in size upon dilution with water under gentle stirring.
Keywords: Self emulsifying drug delivery system, surfactant, co-surfactant.
DOI
https://doi.org/10.22270/jddt.v4i6.989
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