A Review on Design and Application of Advanced Superporous Hydrogels in Gastro Retentive Drug Delivery System
Abstract
Superporous hydrogels (SPHs) are a promising type of material for gastro-retentive drug delivery systems (GRDDS). They are attracting attention because of their ability to swell very quickly, their strong mechanical structure, and their long gastric retention. These hydrogels contain a network of interconnected pores that allows them to absorb a large amount of gastric fluid within minutes. As a result, they expand to many times larger than their original size. This rapid swelling helps them stay in the stomach by preventing their passage through the pylorus, which supports a longer residence time and controlled release of drugs at the required site. SPHs can be prepared from natural or synthetic polymers and often include cross-linking agents, gas-forming substances, and bioadhesive components to enhance their function. Their responsiveness to pH and mechanical stress makes them suitable for drugs that are absorbed in specific stomach regions, have poor solubility, or are unstable in the intestine. This review highlights methods of SPH preparation, important design factors, and drug-loading techniques. It also discusses their evaluation in laboratory studies (in vitro) for swelling, strength, and release performance. Despite encouraging results, several challenges remain, including large-scale production, differences in gastric motility, and concerns about polymer-related toxicity. Overall, SPHs hold significant potential to provide reliable, efficient, and patient-friendly options for oral drug delivery. With further research and improved formulation strategies, they may become a key platform for achieving safe and effective gastro-retentive therapies.
Keywords: Super Porous Hydrogels (SPHs), Rapid swelling, Porous structure, Gastric Retention
Keywords:
Super Porous Hydrogels (SPHs), Rapid swelling, Porous structure, Gastric RetentionDOI
https://doi.org/10.22270/jddt.v15i11.7456References
1. Kumar M, Kaushik D. An overview on various approaches and recent patents on gastroretentive drug delivery systems. Recent Pat Drug Deliv Formul. 2018; 12(2):84-92. https://doi.org/10.2174/1872211312666180308150218 PMid:29521255
2. Waqar MA, Mubarak N, Khan AM, Khan R, Shaheen F, Shabbir A. Advanced polymers and recent advancements on gastroretentive drug delivery system; a comprehensive review. Journal of drug targeting. 2024 Jul 2;32(6):655-71. https://doi.org/10.1080/1061186X.2024.2347366 PMid:38652465
3. Kiran CV, Gopinath C. Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS). Materials Today: Proceedings. 2021 Jan 1;46:3056-61. https://doi.org/10.1016/j.matpr.2021 .02.381 https://doi.org/10.1016/j.matpr.2021.02.381
4. Le TN, Her J, Sim T, Jung CE, Kang JK, Oh KT. Preparation of Gastro-retentive Tablets Employing Controlled Superporous Networks for Improved Drug Bioavailability. AAPS PharmSciTech. 2020 Nov 12;21(8):320. https://doi.org/10.1208/s12249-020-01851-5 PMid:33180220
5. Kumar V, Somkuwar S, Singhai AK. A recent update on gastro retentive drug delivery systems. GSC Biol Pharm Sci. 2024;27(1):125-44. doi:10.30574/gscbps.2024.27.1.0119. https://doi.org/10.30574/gscbps.2024.27.1.0119
6. Goyal RK, Guo Y, Mashimo H. Advances in the physiology of gastric emptying. Neurogastroenterology & Motility. 2019 Apr;31(4):e13546 https://doi.org/10.1111/nmo.13546 PMid:30740834 PMCid:PMC6850045
7. Desu PK, Pasam V, Kotra V. Implications of superporous hydrogel composites-based gastroretentive drug delivery systems with improved biopharmaceutical performance of fluvastatin. Journal of Drug Delivery Science and Technology. 2020 Jun 1;57:101668 https://doi.org/10.1016/j.jddst.2020.101668
8. Foudazi R, Zowada R, Manas-Zloczower I, Feke DL. Porous hydrogels: present challenges and future opportunities. Langmuir. 2023 Jan 31;39(6):2092-111. https://doi.org/10.1021/acs.langmuir.2c02253 PMid:36719086
9. Juthi AZ, Li F, Wang B, Alam MM, Talukder ME, Qiu B. pH-responsive super-porous hybrid hydrogels for gastroretentive controlled-release drug delivery. Pharmaceutics. 2023 Mar 2;15(3):816. https://doi.org/10.3390/pharmaceutics15030816 PMid:36986676 PMCid:PMC10053105
10. Sadia S, Jat RK, Malthar P. Superporous hydrogel: an innovative method for secure gastroretentive drug delivery systems. Int J Adv Res Sci Commun Technol. 2024;4(2):47-56. https://doi.org/10.48175/IJARSCT-19607
11. Gadge G, Sabale V, KHADE A. Current approaches on gastro retentive drug delivery system: an overview. International Journal of Pharmacy Research & Technology (IJPRT). 2019;9(2):16-28. https://doi.org/10.31838/ijprt/09.02.04
12. Choudhary H, Raghavan SR. Superfast-expanding porous hydrogels: pushing new frontiers in converting chemical potential into useful mechanical work. ACS Applied Materials & Interfaces. 2022 Mar 9;14(11):13733-42. https://doi.org/10.1021/acsami.2c00645 PMid:35261243
13. Pawar D, Jamindar D, Farooqui NA, Manocha N. Superporous Hydrogel: A Novel Approach for Safe Gastroretentive Drug Delivery System. Journal of Drug Delivery & Therapeutics. 2024 Apr 1;14(4). https://doi.org/10.22270/jddt.v14i4.6458
14. Jhawat V, Gulia M, Maddiboyina B, Dutt R, Gupta S. Fate and applications of superporous hydrogel systems: a review. Current Nanomedicine (Formerly: Recent Patents on Nanomedicine). 2020 Dec 1;10(4):326-41. https://doi.org/10.2174/2468187310999200819201555
15. Shah K, Singh D, Agrawal R, Garg A. Current developments in the delivery of gastro-retentive drugs. AAPS PharmSciTech. 2025 Feb 7;26(2):57. https://doi.org/10.1208/s12249-025-03052-4 PMid:39920556
16. Qing LS, Adnan N, Ghazali S, Noordin N. Effect of gas foaming and porosigen techniques on the properties of superporous hydrogels. Materials Today: Proceedings. 2018 Jan 1;5(10):21841-8. https://doi.org/10.1016/j.matpr.2018.07.040
17. Peppas NA, Mikos AG. Preparation methods and structure of hydrogels. InHydrogels in medicine and pharmacy 2019 Aug 15 (pp. 1-26). CRC press. https://doi.org/10.1201/9780429285097-1 PMid:30740237
18. Jain S, Srinivasan B. An Insight on the Strategical Approach of Gastro-retentive Drug Delivery System. Pharm. Sci. 2023;3:34-54.
19. Mac Kenna N, Morrin A. Inducing macroporosity in hydrogels using hydrogen peroxide as a blowing agent. Materials Chemistry Frontiers. 2017;1(2):394-401. https://doi.org/10.1039/C6QM00052E
20. Verma NK, Singh AK, Yadav V, Singh P, Yadav A, Jaiswal S. Super porous hydrogel based drug delivery system: a review. South Asian Res J Pharm Sci. 2021;3(6):103-110. doi: https://doi.org/10.36346/sarjps.2021.v03i06.004
21. Nser SM, Al-Shohani AD, Abuawad A. Effect of using high molecular weight crosslinker on the physical properties of super porous hydrogel composite. Al Mustansiriyah Journal of Pharmaceutical Sciences. 2023 Oct 9;23(4):355-66. https://doi.org/10.32947/ajps.v23i4.1091
22. Bardajee GR, Mahmoodian H, Boraghi SA, Elmizadeh H, Ziarani NB, Rezanejad Z, Tyagi I, Gaur R, Javadian H. Nanoporous hydrogel absorbent based on salep: Swelling behavior and methyl orange adsorption capacity. Environmental Research. 2023 May 15;22(5):115571. https://doi.org/10.1016/j.envres.2023.115571 PMid:36871943
23. Rehman S, Madni A, Jamil QA, Raza MR, Shukat H, Nadeem A. Preparation and in vitro characterization of graphene oxide impregnated superporous hydrogel beads: An effective approach of gastro-retentive drug delivery system. Polymer-Plastics Technology and Materials. 2024 Nov 21;63(17):2304-26. https://doi.org/10.1080/25740881.2024.2372800
24. Issarachot O, Bunlung S, Kaewkroek K, Wiwattanapatapee R. Superporous hydrogels based on blends of chitosan and polyvinyl alcohol as a carrier for enhanced gastric delivery of resveratrol. Saudi Pharmaceutical Journal. 2023 Mar 1;31(3):335-47. https://doi.org/10.1016/j.jsps.2023.01.001 PMid:37026050 PMCid:PMC10071363
25. Grosso R, Benito E, Carbajo-Gordillo AI, García-Martín MG, Perez-Puyana V, Sánchez-Cid P, de-Paz MV. Biodegradable guar-gum-based super-porous matrices for gastroretentive controlled drug release in the treatment of helicobacter pylori: a proof of concept. International Journal of Molecular Sciences. 2023 Jan 23;24(3):2281. https://doi.org/10.3390/ijms24032281 PMid:36768604 PMCid:PMC9917163
26. Soumya B, Arvapalli S, Sharma JV, Nagaraju P. Design, characterization and In-vitro evaluation of superporous hydrogel tablets of nimodipine. Journal of Drug Delivery and Therapeutics. 2019 May 1;9(3):300-9. https://doi.org/10.22270/jddt.v9i3.2659
27. Shah K, Singh D, Agrawal R, Garg A. Current developments in the delivery of gastro-retentive drugs. AAPS PharmSciTech. 2025 Feb 7;26(2):57. https://doi.org/10.1208/s12249-025-03052-4 PMid:39920556
28. Raghu Kiran CVS, Gopinath C. Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS). Mater Today Proc. 2021. https://doi.org/10.1016/j.matpr.2021.02.381
29. Rehman S, Madni A, Jamil QA, Raza MR, Shukat H, Nadeem A. Preparation and in vitro characterization of graphene oxide impregnated superporous hydrogel beads: An effective approach of gastro-retentive drug delivery system. Polymer-Plastics Technology and Materials. 2024 Nov 21;63(17):2304-26. https://doi.org/10.1080/25740881.2024.2372800
30. Kumari, P. V. K., Sharmila, M., & Rao, Y. S. (2020). Super porous hydrogels: A review. Journal of Pharmaceutical Research International, 32(13), 153-165. https://doi.org/10.9734/jpri/2020/v32i1330595
31. Waqar MA, Mubarak N, Khan AM, Khan R, Shaheen F, Shabbir A. Advanced polymers and recent advancements on gastroretentive drug delivery system; a comprehensive review. Journal of drug targeting. 2024 Jul 2;32(6):655-71. https://doi.org/10.1080/1061186X.2024.2347366 PMid:38652465
32. Mishra R, Zaffar A, Kumar S, Verma AK, Gautam H. Gastroretentive Swellable and Floating Systems: An Innovative and Promising Strategy for Drug Delivery-A Comprehensive Review. Journal of Drug Delivery & Therapeutics. 2024 Oct 1;14(10). https://doi.org/10.22270/jddt.v14i10.6800
33. Dubey A, Ovais M, Bisen AC, Rajendiran A. Advancements and Challenges in Gastroretentive Drug Delivery Systems: A Comprehensive Review of Research Innovation, Technologies, and Clinical Applications. Recent Advances in Drug Delivery and Formulation. 2025 Apr 28. https://doi.org/10.2174/0126673878342430250414114531 PMid:40296614
34. Le TN, Her J, Sim T, Jung CE, Kang JK, Oh KT. Preparation of Gastro-retentive Tablets Employing Controlled Superporous Networks for Improved Drug Bioavailability. AAPS PharmSciTech. 2020 Nov 12;21(8):320. https://doi.org/10.1208/s12249-020-01851-5 PMid:33180220
35. Choudhary H, Raghavan SR. Superfast-expanding porous hydrogels: pushing new frontiers in converting chemical potential into useful mechanical work. ACS Applied Materials & Interfaces. 2022 Mar 9;14(11):13733-42. https://doi.org/10.1021/acsami.2c00645 PMid:35261243
36. Khalaf, M. M., Alinejad, S. S., Sajad, O., & Rasool, B. K. (2023). Gastro-retentive drug delivery technologies and their applications with cardiovascular medications. Journal of Population Therapeutics & Clinical Pharmacology, 30(5), e1-e19. https://doi.org/10.47750/jptcp.2023.30.05.001
37. Moriya GA, Mazumder RU, Padhi SW, Mishra RA. Gastrorententive hydrogels responsive to external stimuli for novel drug delivery. Int J App Pharm. 2024 Jul 7;16(4):1-4. https://doi.org/10.22159/ijap.2024v16i4.51051
38. Li X, Ullah MW, Li B, Chen H. Recent progress in advanced hydrogel‐based embolic agents: from rational design strategies to improved endovascular embolization. Advanced Healthcare Materials. 2023 Jul;12(17):2202787. https://doi.org/10.1002/adhm.202202787 PMid:36905401
39. Shah K, Singh D, Agrawal R, Garg A. Current developments in the delivery of gastro-retentive drugs. AAPS PharmSciTech. 2025 Feb 7;26(2):57. https://doi.org/10.1208/s12249-025-03052-4 PMid:39920556
40. Dhiman S, Philip N, Gurjeet Singh T, Babbar R, Garg N, Diwan V, Singh P. An insight on novel approaches & perspectives for gastro-retentive drug delivery systems. Current Drug Delivery. 2023 Jun 1;20(6):708-29. https://doi.org/10.2174/1567201819666220819200236 PMid:35993477
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