HEPATOPROTECTIVE ACTIVITY OF WHOLE PLANT EXTRACT OF LEPTADENIA PYROTECHNICA AGAINST PARACETAMOL INDUCED DAMAGE IN RATS
The liver serves as a processing laboratory, redistribution centre and a receiving depot of the body. In the light of these roles, the effect of methanolic extract of whole plant of Leptadenia pyrotechnica on paracetamol induced liver damage in wistar rats was assessed. paracetamol (500mg/kg,p.i) was used to induce hepatotoxicity. EighteenÂ (18) albino rats of wistar strain (150-200gm) were used for the studies and were divided into 3 groups of six (6) rats per each. Group A served as control and received vehicle, group B (paracetamol treated), and group C (extract and paracetamol treated groups). The administered was done via oral gavages with methanolic extract of whole plant of Leptadenia pyrotechnica at 150ml/kg/day body weight daily, the administration of the extract lasted for saventh (7) days period after which the animals sacrificed, blood and tissue were obtained for biochemical and histological analysis. Serum enzyme assay results reveals methanolic extract of whole plant of Leptadenia pyrotechnica recorded a marked reduction in the elevated activities of the hepatic enzymes viz; SGOT, SGPT, ALP and Total bilirubin levels of rats. More so, the micrograph of paracetamol group compared with control group showed evidence of liver necrosis as indicated by distended hepatocytes, compression of sinusoids, fatty change and vacuolation of cytoplasm. The treated groups of the extract generally showed mild defects when compared with the control group. It is however interesting to know that the 100% Leptadenia pyrotechnica treated group showed a healthy liver cells as in the case with the control groups. Hence, from the above findings, it is obvious that methanolic extract of whole plant of Leptadenia pyrotechnica has hepatoprotective and hepatocurative potentials in hepatocellular disorders.
Keyword: Leptadenia pyrotechnica, hepatoprotective activity and paracetamol.
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