Recent Advances in Solid Lipid Nanoparticle Preparation: Methods, Ingredients, and Routes of Administration
Abstract
Objective: To identify the importance of Solid lipid nanoparticles (SLNs), their most recent methods of preparation and the drugs, lipid(s) and surfactant(s) most recently used for carrier development. Methods: Original articles were identified through searches of MEDLINE/PubMed for within the last 5 years (2020-February 2025), with the following search terms; solid lipid nanoparticles. The main aim was to find original articles/ research, this led to another search but excluded evaluation. Study Selection and exclusion criteria: Articles that discussed active pharmaceutical “drugs” were selected for this study and exclusion criteria of “NOT review NOT MRNA NOT DNA NOT RNA” to narrow down the articles. Data Synthesis: More than 500 articles were identified and further reviewed in the literature and were categorized according to the method in which the SLN were prepared; homogenization and/or high-pressure homogenization, ultrasonication, solvent injection and/or solvent evaporation phase inversion, microemulsion/emulsification, nano spray drying and/or others and combination methods. Conclusion: As more specific drug targeting and drug delivery systems become more of an interest in the drug development field, solid lipid nanoparticles will be of continuance importance for a strategic role in nanoparticle formulations.
Keywords: Solid lipid nanoparticles (SLNs), Homogenization, Ultrasonication, Solvent injection
Keywords:
Solid lipid nanoparticles, Homogenization, Ultrasonication, Solvent injectionDOI
https://doi.org/10.22270/jddt.v15i6.7160References
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