Formulation and Evaluation of Guava Leaf-Based Nanogel for Mouth Ulcer Treatment
Abstract
Mouth ulcers, also known as aphthous ulcers, are painful lesions affecting the oral mucosa, causing discomfort and irritation. Conventional treatments, such as antiseptic gels and corticosteroids, provide temporary relief but may have side effects with prolonged use. Guava leaves (Psidium guajava) contain bioactive compounds such as flavonoids, tannins, and polyphenols, which exhibit antimicrobial, anti-inflammatory, and wound-healing properties. This study focuses on the formulation of a simple, Nanogel using Carbopol 934 as a base for the treatment of mouth ulcers. The gel was prepared by incorporating guava leaf extract into a Carbopol-based gel matrix and was evaluated for pH, viscosity, spreadability, drug content, and stability. The formulation showed good Nanogel properties, proper viscosity, and a suitable pH 6.5-7.5, making it safe and effective for oral application. This study suggests that a guava leaf-based Nanogel can be a natural, cost-effective alternative for mouth ulcer treatment.
Keywords: Mouth ulcer, Guava leaf extract, Nanogel gel, Carbopol 934
Keywords:
Mouth ulcer, Guava leaf extract, Nanogel, carbopol 934DOI
https://doi.org/10.22270/jddt.v15i4.7069References
1. Shinde SP, Lobo CB, Rajput HSS, Nikam GF, Nanotechnology in Drug Delivery System: A New Approach, Journal of Drug Delivery and Therapeutics, 2025; 15(2):112-123. https://doi.org/10.22270/jddt.v15i2.6988
2. Soni KS, Desale SS, Bronich TK. Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation, J Control Release, 2016; 28(240):109-126. https://doi.org/10.1016/j.jconrel.2015.11.009 PMid:26571000 PMCid:PMC4862943
3. Christenhusz, M. J. M., & Byng, J. W, The number of known plants species in the world and its annual increase, Phytotaxa, 2016; 261(3): 201-217. https://doi.org/10.11646/phytotaxa.261.3.1
4. Kumar M, Tomar M, Amarowicz R, Saurabh V, Nair M S, Maheshwari C, Sasi M, et al, Guava (Psidium guajava) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities, Foods 2021; 10, 752. https://doi.org/10.3390/foods10040752 PMid:33916183 PMCid:PMC8066327
5. Porter SR, Leao JC, Oral ulcers and its relevance to systemic disorders, Alimentary pharmacology & therapeutics, 2005; 21(4):295-306. https://doi.org/10.1111/j.1365-2036.2005.02333.x PMid:15709981
6. Subiksha PS, Various remedies for recurrent aphthous ulcer-a review, Journal of Pharmaceutical Sciences and Research, 2014; 6(6):251.
7. Dellinger TM, Livingston HM, Aspirin burn of the oral cavity, Annals of Pharmacotherapy, 1998; 32(10):1107. https://doi.org/10.1345/aph.17370 PMid:9793606
8. Parry J, Porter S, Scully C, Flint S, Parry MG, Mucosal lesions due to oral cocaine use, British dental journal, 1996; 180(12):462-464. https://doi.org/10.1038/sj.bdj.4809127 PMid:8703599
9. Scully C, Porter S. Oral mucosal disease, recurrent aphthous stomatitis, British Journal of Oral and Maxillofacial Surgery, 2008; 46(3):198-206. https://doi.org/10.1016/j.bjoms.2007.07.201 PMid:17850936
10. Edgar NR, Saleh D, Miller RA, Recurrent aphthous stomatitis: a review, The Journal of clinical and aesthetic dermatology, 2017; 10(3):26-36
11. Swain N, Pathak J, Poonja LS, Penkar Y, Etiological factors of recurrent aphthous stomatitis: A common perplexity, J Contemp Dent, 2012; 2(3):96-100. https://doi.org/10.5005/jp-journals-10031-1019
12. Akintoye SO, Greenberg MS, Recurrent aphthous stomatitis, Dental Clinics of North America, 2014; 58(2):281. https://doi.org/10.1016/j.cden.2013.12.002 PMid:24655523 PMCid:PMC3964366
13. Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S, Recurrent aphthous stomatitis a review, Journal of oral pathology & medicine, 2012; 41(8):577-83. https://doi.org/10.1111/j.1600-0714.2012.01134.x PMid:22413800
14. Tarakji B, Gazal G, Al-Maweri SA, Azzeghaiby SN, Alaizari N, Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners, Journal of international oral health: JIOH, 2015; 7(5):74.
15. Swain N, Pathak J, Poonja LS, Penkar Y, Etiological factors of recurrent aphthous stomatitis: A common perplexity, J Contemp Dent, 2012; 2(3):96-100. https://doi.org/10.5005/jp-journals-10031-1019
16. Parvez GM, Shakib U, Khokon M, Sanzia M, A short review on a nutritional fruit: guava, Open Access: Toxicology and Research, 2018; 1:1-8. https://doi.org/10.5005/jp-journals-10031-1019
17. Uduak EU, Timbuak JA, Musa SA, Ikyembe DT, Abdurrashid S, Hamman WO, Ulceroprotective effect of methanol extract of Psidium guajava leaves on ethanol induced gastric ulcer in adult wistar rats, Asian Journal of Medical Sciences, 2012; 4(2):75-78.
18. Puntawong S, Okonogi S, Pringproa K, In vitro antibacterial activity of Psidium guajava Lin, leaf extracts against pathogenic bacteria in pigs, Chiang Mai Univ J Nat Sci, 2012; 11(2):127-134.
19. Chen HY, Yen GC. Antioxidant activity and free radical-scavenging capacity of extracts from guava (Psidium guajava) leaves, Food chemistry, 2007; 101(2):686-694. https://doi.org/10.1016/j.foodchem.2006.02.047
20. Parveen B, Parveen A, Parveen R, Ahmad S, Ahmad M, Iqbal M, Challenges and opportunities for traditional herbal medicine today, with special reference to its status in India, Ann Phytomed, 2020; 9(2):97-112. https://doi.org/10.21276/ap.2020.9.2.8
21. Rathnayake AM, Maathumai S, A Review On Nutritional Composition And Pharmacological Effects Of Guava;(Psidium Guajava) Carpathian Journal of Food Science & Technology, 2022; 16(1). https://doi.org/10.34302/crpjfst/2024.16.1.12
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