Humic nanoparticles as a tool for eliminating the toxicity of zinc L-valinate

Vladimir N. Tumasov; Alla V. Marukhlenko; Anton V. Syroeshkin

doi:10.22270/jddt.v15i2.7010

Authors

Vladimir N. Tumasov Department of Pharmaceutical Chemistry and Organization of Pharmaceutical Business, Faculty of Medicine, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow, 119991, Russian Federation https://orcid.org/0000-0003-2844-0537
Alla V. Marukhlenko Department of pharmaceutical and toxicological chemistry, Medical Institute, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation https://orcid.org/0000-0003-0174-9489
Anton V. Syroeshkin Department of pharmaceutical and toxicological chemistry, Medical Institute, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Abstract

Earlier, we showed (Morozova M.A. et al., 2022) that solutions of the humic acids (HAs) and fulvic acids (FAs) complex used as a solvent are applicable for increasing the solubility and colloidal stability of antiviral drugs. In this study, we investigated the ability of humates to form stable colloidal systems with chelated zinc complexes with amino acids. The study of the dispersion properties of the samples was carried out using the dynamic light scattering (DLS) technique. There were obtained HAs and FAs dilutions that form a colloidal solution with zinc chelate complexes with specified characteristics of particle size and zeta potential. The solutions contained mainly 20 nm nanoparticles and their zeta potential was -24 mV. The toxicity was assessed using the Spirotox method. A comparative toxicological analysis of zinc valinate samples dissolved in HAs and water showed that the use of HAs as an adjuvant allows for a radical decrease in the toxicity of zinc chelate.

Keywords: extract of humic substances; fulvic acid; zinc chelate complexes; zincvalinate; toxicity; Spirotox-method

Keywords:

extract of humic substances, fulvic acid, zinc chelates, L-valine, toxicity, Spirotox test

DOI

https://doi.org/10.22270/jddt.v15i2.7010

Author Biographies

Vladimir N. Tumasov , Department of Pharmaceutical Chemistry and Organization of Pharmaceutical Business, Faculty of Medicine, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow, 119991, Russian Federation

Department of Pharmaceutical Chemistry and Organization of Pharmaceutical Business, Faculty of Medicine, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow, 119991, Russian Federation

Alla V. Marukhlenko, Department of pharmaceutical and toxicological chemistry, Medical Institute, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Department of pharmaceutical and toxicological chemistry, Medical Institute, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Anton V. Syroeshkin, Department of pharmaceutical and toxicological chemistry, Medical Institute, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Department of pharmaceutical and toxicological chemistry, Medical Institute, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation.

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