A Systematic Review of Nano-Encapsulation for Improving the Bioavailability of Dietary Supplements and Nutraceuticals
Abstract
Nanoencapsulation is a growing technique in the field of nutraceuticals and dietary supplements, offering several advantages over non-encapsulated forms. This systematic review assesses the impact of nanoencapsulation on key factors such as bioavailability, stability, tolerance, and encapsulation efficiency. The selected studies demonstrate that nanoencapsulation enhances the protection and controlled release of bioactive compounds, leading to improved efficacy and therapeutic potential. Furthermore, it increases the bioavailability of nutrients and active ingredients while maintaining their stability under different conditions. The review also highlights the positive effects on product safety and consumer tolerance, making nanoencapsulation a promising strategy for optimizing the formulation of dietary supplements. These findings suggest that nanoencapsulation could play a critical role in advancing the effectiveness of nutraceutical products.
Keywords: Nanoencapsulation, dietary supplements, nutraceuticals, efficacy, bioavailability, stability
Keywords:
Nanoencapsulation, dietary supplements, nutraceuticals, efficacy, bioavailability, stabilityDOI
https://doi.org/10.22270/jddt.v14i10.6829References
Vasantharaj S, Ravindran R, Ramalingam S, Selvaraj A. A comparative study of optimized naringenin nanoformulations using nano-carriers (PLA/PVA and zein/pectin) for improvement of bioavailability. Food Chem. 2021;343:130950. doi:10.1016/j.foodchem.2021.130950.
Nasti A, Tammaro L, De Masi D, Pallotta L, Papa A, Pierri G, et al. Alpha-tocopherol-loaded polycaprolactone nanoparticles improve the inflammation and systemic oxidative stress of arthritic rats. J Tradit Complement Med. 2021;12(3):215-24. doi:10.1016/j.jtcme.2021.12.003.
Arriagada F, González M, Chandía D, Iglesias A, González C, González E. Amphiphilic polymeric nanoparticles encapsulating curcumin: Antioxidant, anti-inflammatory and biocompatibility studies. Mater Sci Eng C Mater Biol Appl. 2020;111793. doi:10.1016/j.msec.2020.111793.
Jain P, Kaur J, Sood AK, Vishwakarma N. Biodegradable chitosan-sodium alginate-oleic acid nanocarrier promotes bioavailability and target delivery of lutein in rat model with no toxicity. Food Chem. 2020;330:127195. doi:10.1016/j.foodchem.2020.127195.
Bai J, Tang X, Zhang Z, Lin J, Wang W, Tian F, et al. Casein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin. Int J Pharm. 2019;566:118652. doi:10.1016/j.ijpharm.2019.118652.
Mu H, Zhang Z, Liu G, Cheng D, Wang Y. Chitosan-Tripolyphosphate Nanoparticles Prepared by Ionic Gelation Improve the Antioxidant Activities of Astaxanthin in the In Vitro and In Vivo Model. Antioxidants (Basel). 2022;11(3):479. doi:10.3390/antiox11030479.
Zaky AA, El-Batal AI, Mady MM, Saleh NM, Ibrahim H, Kassem NM, et al. Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects. J Nanopart Res. 2020;22(9):1-16. doi:10.1007/s11051-020-04832-8.
Liu C, Zhang L, Li W, Cao J, Fan Y, Wang W, et al. Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy. Pharmaceutics. 2022;14(9):1976. doi:10.3390/pharmaceutics14091976.
Ali SA, El-Sherbiny IM, Mohamed MS, Salah El-Din RA, El-Rafie SM. Development and characterization of a fucoidan-based nanoemulsion using Nigella sativa oil for improvement of anti-obesity activity of fucoxanthin in an obese rat model. Int J Biol Macromol. 2023;233:123867. doi:10.1016/j.ijbiomac.2023.123867.
Tiwari N, Verma N, Jain V, Prakash A, Mishra PR. Dietary supplementation of encapsulated anthocyanin loaded-chitosan nanoparticles attenuates hyperlipidemic aberrations in male Wistar rats. Curr Res Pharmacol Drug Discov. 2021;2(100051):100051. doi:10.1016/j.carpta.2021.100051.
Meng Z, Luo M, Zhang B, Zhong W, Li H, Wu Y. Formulation of Piperine Nanoparticles: In Vitro Breast Cancer Cell Line and In Vivo Evaluation. Polymers (Basel). 2022;14(7):1349. doi:10.3390/polym14071349.
Wei Y, Zhang J, Xia Z, Ma Y, Zhao W, Chen L, et al. Hyaluronic acid coating on the surface of curcumin-loaded ZIF-8 nanoparticles for improved breast cancer therapy: An in vitro and in vivo study. Colloids Surf B Biointerfaces. 2021;203:111759. doi:10.1016/j.colsurfb.2021.111759.
Albatayneh OB, Al-Shami IH, Badwan AA, Alsaleh FM, Mohammad MK, Alfarsi MA, et al. Innovative coenzyme Q10-loaded nanoformulation as an adjunct approach for the management of moderate periodontitis: preparation, evaluation, and clinical study. Drug Deliv Transl Res. 2021;11(3):1179-93. doi:10.1007/s13346-019-00698-z.
Hasan M, Haque MA, Rahman KM, Rashid MA. Quercetin-loaded chitosan nanoparticles ameliorate adjuvant-induced arthritis in rats by regulating anti-oxidant enzymes and downregulating pro- and inflammatory cytokines. Inflammopharmacology. 2022;30(3):899-911. doi:10.1007/s10787-022-01118-4.
Tan C, Xiang Q, Cheng J, Li Z, Jiang Y, Song W, et al. TPGS and Doca dual-modified mesoporous silica nanoparticle-supported lipid bilayers enhance the efficient delivery and in vivo absorption of Coenzyme Q10. J Drug Deliv Sci Technol. 2023;80:104243. doi:10.1016/j.jddst.2023.104243.
Ye C, Yuan Y, Zhang Y, Gao Y, Jiang L. Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin. Int J Pharm. 2023;630:123216. doi:10.1016/j.ijpharm.2023.123216.
Manzoor MF, Ahmad N, Ahmed Z, Siddique R, Zeng XA, Rahaman A, et al. Nano-encapsulated Iron and Folic Acid-Fortified Functional Yogurt Enhance Anemia in Albino Rats. Front Nutr. 2021;8:654624. doi:10.3389/fnut.2021.654624.
Wang J, Yu W, Chen G, Kang L, Jin Y, Yang H, et al. Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)-graft-chitosan nanoparticles: preparation, in vitro evaluation, and pharmacokinetics in rats. J Sci Food Agric. 2021;101(13):5389-97. doi:10.1002/jsfa.11435.
Vasantharaj S, Ravindran R, Ramalingam S, Selvaraj A. A comparative study of optimized naringenin nanoformulations using nano-carriers (PLA/PVA and zein/pectin) for improvement of bioavailability. Food Chem. 2021;343:130951. doi:10.1016/j.foodchem.2021.130951
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