Method Development and Stress Degradation Profile of Umifenovir by UV Spectrophotometry
Degradation Profile of Umifenovir by UV Spectrophotometry
Abstract
A simple, selective, and economical UV spectrophotometric method has been developed using ethanol as solvent (50%) to determine the umifenovir content in bulk and pharmaceutical dosage formulations. At a pre-determined λ max of 260 nm, it has shown linear in the 10-50 µg/mL range and exhibited a good correlation coefficient (R2 = 0.9927) and excellent mean recovery (98.00–104%). The method was validated statistically, and recovery studies were done for linearity, precision, and accuracy. The obtained results proved that the method can be employed for the routine analysis of umifenovir in bulks and commercial formulations.
Keywords: UV spectrophotometry, Umifenovir, Validation, Method development, Stress Degradation
Keywords:
UV spectrophotometry, Umifenovir,, Validation, Method development, Stress DegradationDOI
https://doi.org/10.22270/jddt.v14i9.6789References
Dong H, He Y, Ting W, Huan Y, Rong Y and Zongan L. Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID-19): A Systematic review and meta-analysis. Journal of Medical Virology, 2021;93(1):481-490. https://doi.org/10.1002/jmv.26256 PMid:32617989 PMCid:PMC7361300
Philippe-Henri S, Hassane SY, Audrey S, Marie A, Lionel T, Olivier T, Victorie V, Najet Y, Bernard D. Intrinsic stability of the antiviral drug umifenovir by stress testing and DFT. Journal of Pharmaceutical and Biomedical Analysis, 2021;196:113934. https://doi.org/10.1016/j.jpba.2021.113934 PMid:33549876
Angirekula N, Mathrusri Annapurna M. Quantification of arbidol by RP-HPLC with photodiode array detection. Asian Journal of Pharmaceutics 2018, 12(2):553-557.
Srinivasa Rao S, Neelu Jain. Validated stability indicating method for determination of umifenovir-remdesivir in presence of its degradation products. International Journal of Development Research. 2021;11(4):46227-46232. https://doi.org/10.37118/ijdr.21666.04.2021
Muzaffar I, Faisal I, Essam AA, Faisal I, Mohd Abul K, Sulaiman SA. A Validated UPLC-MS/MS method for rapidly quantifying Umifenovir in plasma samples and its greenness assessment. Separations. 2023;10(7):379. https://doi.org/10.3390/separations10070379
Damle MC, Phadtare SA, Raskar HD, Gadge KG, Mehendre R, Bothara KG. A validated HPTLC method for determination of arbidol from pharmaceutical formulation. International Journal of ChemTech Research. 2010;2(2):1042-1046
Xiao L, Yu-Wei H, Juan L, Xiao L, Yu-Wei H, Juan L, Xiao-Bo L, Kai-Shun B. Determination of arbidol in human plasma by LC-ESI-MS. Journal of Pharmaceutical and Biomedical Analysis. 2007;43(1):371-375. https://doi.org/10.1016/j.jpba.2006.06.039 PMid:16884882
Validation of analytical procedures: text and methodology, in: International Conference on Harmonization (ICH), Q2(R1), IFPMA, Geneva, Switzerland, 2005.
ICH Q1A (R2), International Conference on Harmonization (ICH). Stability Testing of New Drug Substances and Products, IFPMA, Geneva (2003).
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