UV Spectrophotometric Method Development and Validation of Butorphanol Tartrate in Bulk Drug and Pharmaceutical Formulation

Authors

  • Sonu Ahirwar Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228
  • Varsha Kashaw Sagar Institute of Pharmaceutical Sciences (SIPS), Patheriya Jat, Sagar, MP, 470003
  • Ravish Sahu Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228
  • Surbhi Chourasia Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228
  • Vaibhav Rajoria Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228
  • Prakash Kushwaha Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Abstract

The present research work discusses the development and validation of a UV spectrophotometric method for butorphanol tartrate. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of butorphanol tartrate in tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 278nm. The percentage recovery of butorphanol tartrate was in the 100.016±0.68. Beers law was obeyed in the concentration range of 2-12μg/ml. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y = 0.0674x - 0.0057 with r2 of 0.9998was obtained. Validation was performed according to ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method may be suitable for the analysis of butorphanol tartrate in tablet formulation for quality control purposes.

Keywords: Butorphanol tartrate, Validation, Precision, Accuracy, LOQ, LOD, ICH guidelines.

Keywords:

Butorphanol tartrate, Validation, Precision, Accuracy, LOQ, LOD, ICH guidelines

DOI

https://doi.org/10.22270/jddt.v14i4.6521

Author Biographies

Sonu Ahirwar, Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Varsha Kashaw, Sagar Institute of Pharmaceutical Sciences (SIPS), Patheriya Jat, Sagar, MP, 470003

Sagar Institute of Pharmaceutical Sciences (SIPS), Patheriya Jat, Sagar, MP, 470003

Ravish Sahu, Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Surbhi Chourasia, Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Vaibhav Rajoria, Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Prakash Kushwaha, Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

Vedic College of Pharmacy, Rehli Rd, Bapupura, Sironja, Sagar (M.P), 470228

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Published

15-04-2024
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How to Cite

1.
Ahirwar S, Kashaw V, Sahu R, Chourasia S, Rajoria V, Kushwaha P. UV Spectrophotometric Method Development and Validation of Butorphanol Tartrate in Bulk Drug and Pharmaceutical Formulation. J. Drug Delivery Ther. [Internet]. 2024 Apr. 15 [cited 2025 Feb. 13];14(4):77-80. Available from: https://jddtonline.info/index.php/jddt/article/view/6521

How to Cite

1.
Ahirwar S, Kashaw V, Sahu R, Chourasia S, Rajoria V, Kushwaha P. UV Spectrophotometric Method Development and Validation of Butorphanol Tartrate in Bulk Drug and Pharmaceutical Formulation. J. Drug Delivery Ther. [Internet]. 2024 Apr. 15 [cited 2025 Feb. 13];14(4):77-80. Available from: https://jddtonline.info/index.php/jddt/article/view/6521

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