The Comprehensive Review: Exploring Future Potential of Nasopulmonary Drug Delivery Systems for Nasal Route Drug Administration

Abstract

This comprehensive review aims to explore the future potential of nasopulmonary drug delivery systems for the administration of drugs through the nasal route. Nasal drug delivery has gained significant attention due to its numerous advantages, including rapid absorption, avoidance of first-pass metabolism, and non-invasive administration. This review provides an overview of the nasal anatomy and physiology, highlighting the factors influencing drug absorption and bioavailability. Additionally, it discusses the various types of nasopulmonary drug delivery systems, such as nasal sprays, powders, and gels, along with their advantages and limitations. Furthermore, the review delves into the challenges associated with nasal drug delivery, including mucociliary clearance, nasal irritation, and formulation issues. The potential applications of nasopulmonary drug delivery systems in the treatment of various diseases, such as allergies, respiratory disorders, and systemic conditions, are also discussed. Finally, the review concludes with an outlook on the future prospects of nasopulmonary drug delivery systems, emphasising the need for further research and development to optimise their efficacy and safety.


Keywords: nasal pulmonary; nasal spray; nasal mucosa; gels; drops; nasal approaches; nasal route; nasal delivery.

Keywords: nasal pulmonary, nasal spray, nasal mucosa, gels, drops, nasal approaches, nasal route, nasal delivery

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Author Biographies

Rahul Pal, Department of Pharmaceutics, NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, 303121, India

Department of Pharmaceutics, NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, 303121, India

Manju Koli, Assistant Professor, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Assistant Professor, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Khushi Srivastava, Research Scholar, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Research Scholar, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Vaisanavi Tiwari, Research Scholar, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Research Scholar, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Aman Kumar Gaur, Research Scholar, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Research Scholar, Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, 243123, India

Prottay Dutta, Assistant Professor, Department of Pharmacy, Usha Martin University, Ranchi, Jharkhand, 835103, India

Assistant Professor, Department of Pharmacy, Usha Martin University, Ranchi, Jharkhand, 835103, India

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1.
Pal R, Pandey P, Koli M, Srivastava K, Tiwari V, Gaur AK, Dutta P. The Comprehensive Review: Exploring Future Potential of Nasopulmonary Drug Delivery Systems for Nasal Route Drug Administration. JDDT [Internet]. 15Mar.2024 [cited 19Apr.2024];14(3):126-3. Available from: https://jddtonline.info/index.php/jddt/article/view/6444