Appetite-inducing effect and safety evaluation of Habb-e-Hilteet in patients with Ḍu‘f al-Ishtihā (anorexia): An open prospective clinical trial

Abstract

Objectives: Anorexia is one among the most prevalent conditions triggering malnutrition, drastic weight loss and serious health issues in people especially older adults. Habb-e-Hilteet is commonly prescribed Unani pharmacopoeial formulation for anorexia. However, no scientific data is available as to its safety and efficacy. The current study assessed the appetite-inducing effect and safety of Habb-e-Hilteet in Ḍu‘f al-Ishtihā (anorexia) patients.


Methods: An open prospective clinical trial was carried out in 95 clinically diagnosed anorexia patients of either gender (19-65 yrs old). The study was approved by Institutional ethic committee and conducted in accordance with the GCP guidelines. Habb-e-Hilteet, 1 pill (500mg) was administered orally in patients twice daily for 14 days. The safety of the formulation was assessed by important pathological and biochemical indices and monitoring adverse events. The efficacy was assessed on the basis of improvement in the Simplified Nutritional Appetite Questionnaire (SNAQ) score.


Results: Out of 95 patients recruited, 78 completed the trial and 17 patients lost to follow-up. The mean age of patients was 29.8 yrs, with the majority (59.0%) being female. Overall therapeutic response was found to be 96%. A significant (P<0.05) increase in the mean SNAQ score was observed after 7 and 14 days of treatment when compared to baseline. No significant difference before and after treatment was observed in pathological and biochemical indices. No adverse events were reported during the entire study period.


Conclusion: The study results indicate that Habb-e-Hilteet could be a viable treatment option for anorexia with no safety concerns.


Keywords: Ḍu‘f al-Ishtihā; Buṭlān al-Shahwa; Anorexia; Habb-e-Hilteet; Unani pharmacopoeal formulation.

Keywords: Ḍu‘f al-Ishtihā, Buṭlān al-Shahwa, Anorexia, Habb-e-Hilteet, Unani pharmacopoeal formulation

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Author Biographies

Noman Anwar, Regional Research Institute of Unani Medicine, Chennai

Regional Research Institute of Unani Medicine, Chennai – 600013, India

Noor Zaheer Ahmed, Regional Research Institute of Unani Medicine, Chennai

Regional Research Institute of Unani Medicine, Chennai – 600013, India

Shahida Begum, Regional Research Institute of Unani Medicine, Chennai

Regional Research Institute of Unani Medicine, Chennai – 600013, India

Athar Parvez Ansari, Regional Research Institute of Unani Medicine, Chennai

Regional Research Institute of Unani Medicine, Chennai – 600013, India

Ammu Jayanthi Viswanathan, Regional Research Institute of Unani Medicine, Chennai

Regional Research Institute of Unani Medicine, Chennai – 600013, India

References

1. Pilgrim AL, Robinson SM, Sayer AA, Roberts HC. An overview of appetite decline in older people. Nurs Older People. 2015; 27(5):29-35. https://doi.org/10.7748/nop.27.5.29.e697
2. S. Nagaraj, "Loss of Appetite in Adult Patients: Effectiveness and Safety of an Appetite Stimulating Medication in an Open-Label, Investigator-Initiated Study in India", Journal of Nutrition and Metabolism, vol. 2022, Article ID 2661912, 7 pages, 2022. https://doi.org/10.1155/2022/2661912
3. Ezeoke CC, Morley JE. Pathophysiology of anorexia in the cancer cachexia syndrome. J Cachexia Sarcopenia Muscle. 2015; 6(4):287-302. https://doi.org/10.1002/jcsm.12059
4. Wilson MM, Thomas DR, Rubenstein LZ, et al. Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr. 2005; 82(5):1074-1081. https://doi.org/10.1093/ajcn/82.5.1074
5. Gama-Axelsson T, Lindholm B, Bárány P, Heimbürger O, Stenvinkel P, Qureshi AR. Self-rated appetite as a predictor of mortality in patients with stage 5 chronic kidney disease. J Ren Nutr. 2013; 23(2):106-113. https://doi.org/10.1053/j.jrn.2012.04.009
6. Liu Y, Zhang PY, Na J, et al. Prevalence, intensity, and prognostic significance of common symptoms in terminally ill cancer patients. J Palliat Med. 2013; 16(7):752-757. https://doi.org/10.1089/jpm.2013.0028
7. Andreae C, Strömberg A, Årestedt K. Prevalence and associated factors for decreased appetite among patients with stable heart failure. J Clin Nurs. 2016; 25(11-12):1703-1712. https://doi.org/10.1111/jocn.13220
8. Rao TS, Asha MR, Ramesh BN, Rao KS. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008; 50(2):77-82. https://doi.org/10.4103/0019-5545.42391
9. Kabīruddin M. Mu'alajāt Sharh al-Asbāb (Urdu Translation), Vol 3. Hyderabad: Hikmat Book Depot; 1916: 193-194, 261.
10. Ṭabarī AAM. Mu'alajāt al-Buqrāṭiyya. (Urdu Translation by CCRUM). Vol 3, New Delhi: CCRUM, Ministry of Health and Family Welfare; 1997: 11-14.
11. Jurjānī I. Dhakhīra Khawārazm Shāhī. (Urdu translation by Khan HH). Vol 6. New Delhi: Idara Kitab al-Shifa; 2010: 335-338.
12. Ibn Sīnā. Al-Qānūn fi'l Ṭibb. (Urdu Translation by Kantoori GH). Vol. I-V Complete set. New Delhi: Idara Kitab al-Shifa; 2014; 3:806-810.
13. Al-Qamarī AM. Minhāj al-Ilāj (Ghina Muna). New Delhi: Central Council for Research in Unani Medicine; 2008: 176-178.
14. Banerjee S, Vijayamohan M, Patel AC, Singh SB, Manjrekar PV, Rathod RT. Prevalence of loss of appetite in patients visiting primary care physicians: a Crosssectional Survey. Indian Journal of Medical Sciences, 2017; 69(2):2-7.
15. Anonymous. National Formulary of Unani Medicine, Part-I. New Delhi: CCRUM, Ministry of Health & Family Welfare, (Dept. of AYUSH) Govt. of lndia; 2006: 15.
16. Hochkogler CM, Liszt K, Lieder B, et al. Appetite-Inducing Effects of Homoeriodictyol: Two Randomized, Cross-Over Interventions. Mol Nutr Food Res. 2017; 61(12):10.1002/mnfr.201700459. https://doi.org/10.1002/mnfr.201700459
17. Nimrouzi M, Zarshenas MM. Anorexia: Highlights in Traditional Persian medicine and conventional medicine. Avicenna J Phytomed, 2018; 8 (1):1-13.
18. Owen AJ, Tran T, Hammarberg K, Kirkman M, Fisher J; COVID-19 Restrictions Impact Research Group. Poor appetite and overeating reported by adults in Australia during the coronavirus-19 disease pandemic: a population-based study. Public Health Nutr. 2021; 24(2):275-281. https://doi.org/10.1017/S1368980020003833
19. van der Meij BS, Wijnhoven HAH, Lee JS, et al. Poor Appetite and Dietary Intake in Community-Dwelling Older Adults. J Am Geriatr Soc. 2017 ;65(10):2190-2197. https://doi.org/10.1111/jgs.15017
20. Hanisah R, Shahar S, Lee FS. Validation of screening tools to assess appetite among geriatric patients. J Nutr Health Aging, 2012; 16:660-665. https://doi.org/10.1007/s12603-012-0056-6
21. Savina C, Donini LM, Anzivino R, De Felice MR, De Bernardini L, Cannella C. Administering the "AHSP Questionnaire" (appetite, hunger, sensory perception) in a geriatric rehabilitation care. J Nutr Health Aging. 2003; 7(6):385-389.
22. Ghani N. Khazā'in al-Adwiya. 3rd Ed. New Delhi: Idara Kitab al-Shifa; 2011: 869-74, 1321-22, 1366-7.
23. Baitār I. Kitāb al-Jāmiʿ li Mufradāt al-Adwiya wa'l Aghdhiya (Urdu translation by CCRUM). Vol 2. New Delhi: CCRUM; 1995: 58-60, 349-52.
24. Kabīruddin M. Makhzan al-Mufradat. New Delhi: Idara Kitab al-Shifa; 2014: 203, 271-3, 401-2.
25. Tariq NA. Taj al-Mufradat. New Delhi: Idara Kitab al-Shifa; 2004: 39-41, 470-1, 765,6.
26. Amalraj A, Gopi S. Biological activities and medicinal properties of Asafoetida: A review. J Tradit Complement Med. 2016; 7(3):347-359. https://doi.org/10.1016/j.jtcme.2016.11.004
27. Ramakrishna Rao R, Platel K, Srinivasan K. In vitro influence of spices and spice-active principles on digestive enzymes of rat pancreas and small intestine. Nahrung. 2003; 47(6):408-412. https://doi.org/10.1002/food.200390091
28. Platel K, Srinivasan K. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung. 2000; 44(1):42-46. https://doi.org/10.1002/(SICI)1521-3803(20000101)44:1<42::AID-FOOD42>3.0.CO;2-D
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Anwar N, Ahmed N, Begum S, Ansari A, Viswanathan A. Appetite-inducing effect and safety evaluation of Habb-e-Hilteet in patients with Ḍu‘f al-Ishtihā (anorexia): An open prospective clinical trial. JDDT [Internet]. 15Nov.2022 [cited 9Dec.2022];12(6):38-3. Available from: https://jddtonline.info/index.php/jddt/article/view/5788