Formulation and Evaluation of Extended Release Gastroretentive Tablets of Metroprolol Succinate
Abstract
This study aimed to produce a gastroretentive floating tablet of Metoprolol succinate and examine the effects of release retardant on in vitro drug release. Metoprolol succinate is a β1 selective antagonist used as an Anti-hypertensive, Antiarrhythmic, and Anti Angina. Metoprolol succinate has 48% oral bioavailability due to limited absorption from the lower gastrointestinal tract. The Metoprolol succinate floating tablets were designed to increase stomach retention, prolong drug release, and enhance drug bioavailability. To shorten the floating lag time, hydrophilic polymers like Hydroxypropyl methyl cellulose (HPMC K4M, K15M, and K100M), polyethylene oxide (PEO 303), and sodium bicarbonate as a gas-producing agent were incorporated into the formulation of the floating tablets. Different batches of Metoprolol succinate floating tablets were prepared by direct compression. All the formulations were evaluated for various quality control tests, such as weight variation, hardness, friability, swelling index, floating lag time, and total floating time. As a dissolution medium, 0.1 N HCl was used to conduct an in vitro release investigation on the tablets. The present study demonstrates the potential of the sustained-release floating tablets of Metoprolol succinate as an alternative to conventional formulations.
Keywords: Bioavailability, Floating tablet, antihypertensive drugs, extended release, Metoprolol succinate, Hydroxypropyl methyl cellulose.
Keywords:
Bioavailability, Floating tablet, antihypertensive drugs, extended release, Metoprolol succinate, Hydroxypropyl methyl celluloseDOI
https://doi.org/10.22270/jddt.v12i5-S.5653References
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