Rapid disintegrating tablets: an effective method for accelerating the therapeutic action of poorly soluble Drugs
Abstract
The ease of administration and increased patient compliance are critical factors in the design of oral drug delivery systems, which continue to be the dominant method of drug delivery despite numerous shortcomings. The rapid disintegrating tablet (RDT) could be a great alternative to traditional tablets because it dissolves quickly when it comes into contact with saliva. Rapid disintegrating tablets (RDTs) are currently more widely available than other tablets to treat various disorders. Due to its ease of manufacture and administration, oral administration is being investigated as the most frequently used route. Due to its rapid disintegration features, water-free use, and simplicity of swallowing, RDTs, particularly for pediatric patients, are effective drug delivery devices. Rapid disintegrating tablets are solid dosage forms that disintegrate in the mouth without water in less than 60 seconds. Rapid disintegration of tablets results in rapid dissolution and, thus, immediate action. The primary objective of this review paper is to discuss the benefits, drawbacks, formulation issues, manufacturing methods, patented technology and evaluation tests. Spray drying, freeze drying, direct compression, moulding, and sublimation are all traditional ways of preparation, however new technologies have been created for the production of RDTs.
Keywords: Rapid disintegrating tablets, patient compliance, spray drying, freeze drying, direct compression.
Keywords:
Rapid disintegrating tablets, patient compliance, spray drying, freeze drying,, direct compressionDOI
https://doi.org/10.22270/jddt.v12i1.5174References
Rathore R, Gupta AK, Parashar AK. Formulation and Evaluation of fast dissolving films of Granisetron Hydrochloride. JDDT [Internet]. 24Apr.2019 [cited 3Jan.2022]; 9(2-A):36-8. Available from: http://jddtonline.info/index.php/jddt/article/view/2768
Chang R, Guo X, Burnside BA, Couch RA. A Review of Fast Dissolving Tablets. PharmTech. 2000; 24(6): 52-58.
Mohire NC, Yadav AV, Gaikwad VK. Novel approaches in development of metronidazole orodispersible tablets. Res J Pharm Technol. 2009 Jun 28; 2(2):283-6.
Parashar AK, Kakde D, Chadhar V, Devaliya R, Shrivastav V, Jain UK. A review on solid lipid nanoparticles (SLN) for controlled and targeted delivery of medicinal agents. Curr Res Pharm Sci. 2011; 1(2):37-47.
Jire DS, Gosavi NS, Badhe RB, Jagdale DH. Mouth dissolving tablet: A novel drug delivery system. Asian Journal of Pharmaceutical Research. 2021 Aug 14; 11(3):180-6. https://doi.org/10.52711/2231-5691.2021.00033
Parashar AK, Patel P, Gupta A, Jain N, Kurmi B. Synthesis Characterization and in vivo Evaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin. Drug Del Letters. 2019; 9:248-63. https://doi.org/10.2174/2210303109666190401231920
Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPs PharmSciTech. 2004 Sep; 5(3):10-5. https://doi.org/10.1208/pt050336
Parashar AK, Singh G. Synthesis and characterization of ligand anchored poly propyleneimine dendrimers for the treatment of brain glioma. Jou. of Med. P'ceutical & Allied Sci. 2021; 10(3)3:2784-2789. https://doi.org/10.22270/jmpas.v10i3.1084
Reddy LH, Ghosh B, Rajneesh. Fast dissolving drug delivery system: A review of literature. Indian J Pharm Sci 2002; 64(4):331‐336.
Parashar AK, Nema RK. A Review on novel techniques for drug delivery to the brain. Current Research in Pharmaceutical Sciences. 2012; 5:134-41.
Lopez FL, Ernest TB, Tuleu C, Gul MO. Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms. Expert opinion on drug delivery. 2015 Nov 2; 12(11):1727-40. https://doi.org/10.1517/17425247.2015.1060218
Abay FB, Ugurlu T. Orally disintegrating tablets: a short review. Journal of Pharmaceutics & Drug Development. 2015 Jun 25;3(3):303. https://doi.org/10.15744/2348-9782.3.303
Comoglu T, Unal B. Preparation and evaluation of an orally fast disintegrating tablet formulation containing a hydrophobic drug. Pharm Dev Technol [Internet]. 2015; 20(1):60-4. Available from: http://dx.doi.org/10.3109/10837450.2013.862636 https://doi.org/10.3109/10837450.2013.862636
Parkash V, Maan S, Deepika, Yadav SK, Hemlata, Jogpal V. Fast disintegrating tablets: Opportunity in drug delivery system. J Adv Pharm Technol Res [Internet]. 2011; 2(4):223-35. Available from: http://dx.doi.org/10.4103/2231-4040.90877 https://doi.org/10.4103/2231-4040.90877
Parashar AK, Kurmi B, Patel P. Preparation and characterization of ligand anchored polymeric nanoparticles for the treatment of epilepsy. Pharmaspire. 2021; 13(1):1-5.
Bradoo R, Shahani S, Poojary S, Deewan B, Sudarshan S. Fast dissolving drug delivery systems. JAMA India 2001; 4(10):27‐31.
Biradar SS, Bhagavati ST, Kuppasad IJ. Fast dissolving drug delivery systems: A brief overview. The Int J Pharmacol 2006; 4(2). https://doi.org/10.5580/879
Parashar AK, Nema RK. Preparation and Characterization of Polymeric Nanoparticles for Sustained Delivery of Insulin. Curr Res Pharm Sci.2012; 153-159.
Bhaskaran S, Narmada GV. Rapid Dissolving tablet: A Novel dosage form. Indian Pharmacist 2002; 1: 9-12.
Devrajan PV and Gore SP, Melt- in- mouth tablets: innovative oral drug delivery system. Express Pharma Pulse 2000; 7(1):16.
Tiwari G, Tiwari R, Bannerjee S, Bhati L, Pandey S, Pandey P, et al. Drug delivery systems: An updated review. Int J Pharm Investig [Internet]. 2012; 2(1):2. Available from: http://dx.doi.org/10.4103/2230-973x.96920 https://doi.org/10.4103/2230-973X.96920
Ghosh T, Ghosh A, Prasad D. A review on new generation orodispersible tablets and its future prospective. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 03(01):1-7.
Vishali T, Damodharan N. Orodispersible tablets: A review. Res J Pharm Technol [Internet]. 2020; 13(5):2522. Available from: http://dx.doi.org/10.5958/0974-360x.2020.00449.7 https://doi.org/10.5958/0974-360X.2020.00449.7
Govind A, Menden MB, Narayna Swami VB. Formulation and evalution of mouth dissolving tablet Asian. J. Pharm. Tech. 2016; 6(2); 91-98 https://doi.org/10.5958/2231-5713.2016.00013.1
Watanabe Y, Koizumi K, Zama Y, Kiriyama M, Mastumoto Y and Mastumoto M. New compressed tablet rapidly disintegrating in saliva in the mouth using crystalline cellulose and a disintegrant. Bio Pharm Bull 1995; 18(9):1308. https://doi.org/10.1248/bpb.18.1308
Panigrahi D, Baghel S, Mishra B. Mouth dissolving tablets: An overview of preparation techniques, evaluation and patented technologies. J Pharm Res 2005; 4(3):35-38.
Seager HJ. Drug delivery products and zydis fast dissolving dosage forms. Pharm Pharmcol 1998; 50:375-382. https://doi.org/10.1111/j.2042-7158.1998.tb06876.x
Sahadev AK, Purwa S. Process involve in the formation of novel drug delivery system. Asian J. Res. Pharma. Sci.2018; 8(4):203-209. https://doi.org/10.5958/2231-5659.2018.00034.6
Kaushik D, Dureja H, Saini TR. Mouth dissolving tablets: A Review. Indian Drugs 2004; 41(4):187-192.
Bhowmik D, Chiranjib B, Krishnakanth, Pankaj, Chandria RM: Fast dissolving tablets: An overview. Journal of Chemical and Pharmaceutical Research 2009; 01(01):163-177.
Deshpande KB, Ganesh NS. Orodispersible tablets: An overview of formulation and technology. International Journal of Pharma and Bio sciences 2011; 02(01):726-734.
Rahane RD, PR Rachh PR, A review on fast dissolving tablet, Journal of Drug Delivery and Therapeutics 2018; 8(5):50-55 https://doi.org/10.22270/jddt.v8i5.1888
Momin S, Khan S, Ghadage DM, Yadav AV, Wagh A, Formulation and evaluation of bilayer tablets of propranolol hydrochloride, Journal of Drug Delivery and Therapeutics. 2017; 7(2):50-57 https://doi.org/10.22270/jddt.v7i2.1399
Published
Abstract Display: 620 
PDF Downloads: 649 PDF Downloads: 686 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.