An insight into the multifarious applications of biosensors and the way forward

Authors

Abstract

A biosensor is a self-reliant integrated device that is proficient in providing specific quantitative or semi-quantitative analytical information. It has been using a biological recognition component that is in direct spatial contact with a transduction component. It is an appliance that consists of two main parts: a bioreceptor and a transducer. Bioreceptor is a biological component that recognizes the objective of an analyte and a transducer. A physicochemical detector component has also been employed that converts the recognition incident into a measurable signal. All the biological materials including enzymes, antibodies, nucleic acids, hormones, receptors, organelles, or whole cells can be used as sensors or detectors in a device. Biosensors can provide low-priced and highly capable devices for being used in other day-to-day applications. It has multifarious potential applications of various types such as monitoring of treatment, disease progression, drug discovery, food control, and environmental monitoring as well as it continues to play a crucial role across numerous fields including biomedical diagnosis. In this review, we give a general introduction to biosensors and their applications, including a brief historical overview.

Keywords: Biosensor, Bio-receptor, Transducer, Analyte, Detector.

Keywords:

Biosensor, Bio-receptor, Transducer, Analyte, Detector

DOI

https://doi.org/10.22270/jddt.v12i5-S.5633

Author Biographies

Mandeep Kaur, Global College of Pharmacy, Anandpur Sahib, Distt. Ropar, Punjab Pincode 140117 India

Global College of Pharmacy,  Anandpur Sahib, Distt. Ropar, Punjab Pincode 140117 India

Shikha Sharma, Global College of Pharmacy, Anandpur Sahib, Distt. Ropar, Punjab Pincode 140117 India

Global College of Pharmacy,  Anandpur Sahib, Distt. Ropar, Punjab Pincode 140117 India

Deepak Kumar, Global College of Pharmacy, Anandpur Sahib, Distt. Ropar, Punjab Pincode 140117 India

Global College of Pharmacy,  Anandpur Sahib, Distt. Ropar, Punjab Pincode 140117 India

References

Mohanty Saraju P, Kougianos Elias, “Biosensors: A tutorial review”. IEEE Potentials, 2006; 25(2): 35-40. DOI: https://doi.org/10.1109/MP.2006.1649009

Korotkaya. E. V, “Biosensors: Design, classification, and applications in the food industry” Foods Raw Mater, 2014; 2(2):161-171. DOI: https://doi.org/10.12737/5476

Mehrotra P, “Biosensors and their applications-a review” J Oral Biol Craniofac Res, 2016; 6(2):153-159. DOI: http://dx.doi.org/10.1016/j.jobcr.2015.12.002

Bhalla N, Jolly P, “Introduction to biosensors: a review” Essays Biochem, 2016; 60(1): 1-8. DOI: 10.1042/EBC20150001

Palchetti. I, Mascini.M, “Biosensor Technology: A Brief History” Sensors and Microsystems, 2009; 54(2): 15-23. DOI: https://doi.org/10.1007/978-90-481-3606-3_2

Last accessed on 15.8.2022. https://www.onlinebiologynotes.com/biosensors-components-working-principle-and-types/.

Dar SA, Sofi MS, “Biosensors: Components and Applications-A Review” 2018; 414-420. DOI: http://data.conferenceworld.in/OUCIP19MAY18/50.pdf

Colomer-Farrarons J, Miribel P, “Portable Bio-Devices: Design of electrochemical instruments from miniaturized to implantable devices” InTech, 2011; DOI: https://doi.org/10.5772/17212

Malhotra S, Verma A, Tyagi N, Kumar V, “Biosensors: Principle, types and applications” IJARIIE, 2017; 3(2): 3639-3644. DOI: https://doi.org/16.0415/IJARIIE-4676

Kaur H, Bhosale A, Shrivastav S, “Biosensors: classification, fundamental characterization and new trends: a review” International Journal of Health Sciences and Research, 2018; 8(6): 315-333

Hasan A, Nurunnabi Md, Morshed M, Paul A, Polini A, KuilaT, Hariri MA, Lee Yong-kyu, Jaffa A, “Recent Advances in Application of Biosensors in Tissue Engineering” BioMed Research International, 2014; 18: DOI: http://dx.doi.org/10.1155/2014/307519

Adrián Javier , Fernández Fátima, Muriano Alejandro , Obregon Raquel ,Ramón-Azcon Javier, Tort Nuria , and Marco M.-Pilar,“Biosensors for Pharmaceuticals and Emerging Contaminants Based on Novel Micro and Nanotechnology Approaches” Hdb Env Chem, 2009; 5: 47–68. DOI: https://doi.org/10.1007/698_2008_10 .

Karimi Maleh Hassan,Orooji Yasin, Karimi Fatemeh, “A critical review on the use of potentiometric based biosensors for biomarkers detection” Biosens. Bioelectron, 2021; 184:113252. Doi: https://doi.org/10.1016/j.bios.2021.113252

Gheorghiu Mihaela, “A short review on cell-based biosensing: challenges and breakthroughs in biomedical analysis” J Biomed Res, 2021; 35(4): 255-263. Doi: https://doi.org/10.7555/JBR.34.20200128

Dzyadevych. S, Jaffrezic-Renault.N, “6 - Conductometric biosensors” WP, 2014: 153-193. Doi: https://doi.org/10.1533/9780857099167.2.153

Danielsson Bengt, “Calorimetric biosensors” J. Biotechnol, 1990; 15(3): 187-200. Doi: https://doi.org/10.1016/0168-1656(90)90026-8

Pohanka Miroslav, “Overview of Piezoelectric Biosensors, Immunosensors and DNA Sensors and Their Applications” Materials (Basel), 2018; 11(3): 448. Doi:10.3390/ma11030448

Hua Yu, Ma Jiaming, Li Dachao, and Wang Ridong,“DNA-Based Biosensors for the Biochemical Analysis: A Review” Biosensors (Basel), 2022; 12(3): 183. Doi: https://doi.org/10.3390/bios12030183

Rocchitta Gaia, Spanu Angela, Babudieri Sergio, Latte Gavinella, Madeddu Giordano, Galleri Grazia, Nuvoli Susanna, Bagella Paola, Demartis Maria Ilaria , Fiore Vito , Manetti Roberto, and Serra Pier Andrea, “Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids” sensors (Basel), 2016; 16(6): 780. Doi: https://doi.org/10.3390/s16060780

Asal Melis , Ozen Ozlem, Sahinler Mert and Polato ˙Ilker, “Recent Developments in Enzyme, DNA and Immuno-Based Biosensors” Sensors, 2018; 18(6): 1-16. Doi: https://doi.org/10.3390/s18061924

Stroble J.K, Stone R.B, Watkins S.E, “An overview of biomimetic sensor technology” Emerald insight, 2009; 29(2): 112-119. Doi: https://doi.org/10.1108/02602280910936219

Strianese Maria , Staiano Maria , Ruggiero Giuseppe , Labella Tullio , Pellecchia Claudio , D'Auria Sabato, “Fluorescence-based biosensors” Methods Mol Biol, 2012; 875: 193-216. Doi: https://doi.org/10.1007/978-1-61779-806-1_9 .

Sharma A, Khan R, Catanante G, Sherazi TA, Bhand S, Hayat A, Louis MJ, “Designed Strategies for Fluorescence-Based Biosensors for the Detection of Mycotoxins” Toxins (Basel), 2018; 10(5): 197. Doi: 10.3390/toxins10050197

Rich Rebecca L , Myszka David G, “Advances in surface plasmon resonance biosensor analysis” Elsevier sci, 2000; 11(1): 54-61. Doi: https://doi.org/10.1016/S0958-1669(99)00054-3

Piliarik Marek , Vaisocherová Hana, Homola Jirí, “Surface plasmon resonance biosensing” Methods Mol Biol, 2009; 503: 65-88. Doi: https://doi.org/10.1007/978-1-60327-567-5_5 .

Dudak Fahriye Ceyda , Boyaci Ismail Hakki, “Rapid and label-free bacteria detection by surface plasmon resonance (SPR) biosensors” Biotechnol j, 2009; 4(7): 1003-1011. Doi: https://doi.org/10.1002/biot.200800316

Aboul-Enein Hassan Y, Stefan Raluca-Ioana & Staden Jacobus F.Van, “Chemiluminescence-Based (Bio)Sensors — An Overview” Crit Rev Anal Chem, 2010; 29(4): 323-331. Doi: https://doi.org/10.1080/10408349891199338

Aboul-Enein Hassan Y, Stefan Raluca-Ioana, Staden Jacobus F.Van, ZhangXinrong R, Garcia-Campana Ana M & Baeyens Willy R. G, “Recent Developments and Applications of Chemiluminescence Sensors” Crit Rev Anal Chem, 2007; 30(4): 271-289. Doi: https://doi.org/10.1080/10408340008984161

Tetyana Phumlani, Shumbula Poslet Morgan and Njengele-Tetyana Zikhona, “Biosensors: Design, Development and Applications” InTech, 2021; 1-172. Doi: https://doi.org/10.5772/intechopen.97576

Haleem Abid, Javaid Mohd, Pratap Singh Ravi, Suman Rajiv, Rab Shanay, “Biosensors applications in medical field: A brief review” SI, 2021; 2: 1-10. Doi: https://doi.org/10.1016/j.sintl.2021.100100

Yakoh A, Pimpitak U, Rengpipat S, Hirankarn N, Chailapakul O, Chaiyo S, “Paper-based electrochemical biosensor for diagnosing COVID-19: Detection of SARS-CoV-2 antibodies and antige” Biosens. Bioelectron, 2021;176: 1-8.Doi: http://www.elsevier.com/locate/bios

Fatima A, Younas I, Fatima MWA, “An Overview on Recent Advances in Biosensor Technology and its Future Application” Archive, 2022; 13(1): 5-10. Doi: https://doi.org/10.51847/LToGI43ji1

Saleem Muhammad, “Biosensors a promising future in measurements” Mater. Sci. Eng, 2013; 51: 1-10. Doi: https://doi.org/10.1088/1757-899X/51/1/012012

Keusgen M, “Biosensors: new approaches in drug discovery” Commun. Biol, 2002; 89: 433-444. Doi: https://doi.org/10.1007/s00114-002-0358-3

Gambari Roberto, Feriotto Giordana, Rutigliano Cristina, Bianchi Nicoletta, And Mischiati Carlo, “Biospecific Interaction Analysis (BIA) of Low-Molecular Weight DNA-Binding Drugs” J. Pharmacol. Exp. Ther,2000; 294(1): 370–377. Doi: https://doi.org/0022-3565/00/2941-0370$03.00/0

Rothmund M. , Schütz Armin , Brecht Andreas , Gauglitz Günter , Berthel Günther & Gräfe Dieter Fresenius, “Label free binding assay with spectroscopic detection for pharmaceutical screening” Anal. Chem., 1997; 359: 15-22. Doi: https://doi.org/10.1007/s002160050529

Seifert Martin , Haindl Stefanie , Hock Bertold, “Development of an enzyme linked receptor assay (ELRA) for estrogens and xenoestrogens” Elsevier sci, 1999; 386(3): 191-199. Doi: https://doi.org/10.1016/S0003-2670(99)00044-6

Alterman Mathias, Sjöbom Hans , Säfsten Pär , Markgren Per-Olof, Danielson U.Helena , Hämäläinen Markku , Löfås Stefan , Hultén Johan, Classon Björn, Samuelsson Bertil , Hallberg Anders, “P1/P1′ modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays” Eur J Pharm Sci., 2001; 13(2): 203-212. Doi: https://doi.org/10.1016/S0928-0987(01)00109-9

Keusgen Michael , Jünger Martina , Krest Ingo, J.Schöning Michael, “Development of a biosensor specific for cysteine sulfoxides” Biosens. Bioelectron, 2003; 18(5- 6): 805-812. Doi: https://doi.org/10.1016/S0956-5663(03)00045-9

Poghossian Arshak, Jablonski Melanie , Koch Claudia, S.Bronder Thomas, Rolka David, Wege Christina, J. Schöning Michael, “Field-effect biosensor using virus particles as scaffolds for enzyme immobilization” Biosens. Bioelectron, 2018; 110: 168-174. Doi: https://doi.org/10.1016/j.bios.2018.03.036

Michael Keusgen, “Biosensors: New approaches in drug discovery” Sci. Nat.,2002; 89(10): 433-444. Doi: https://doi.org/10.1007/s00114-002-0358-3

Romani. A, Minunni M, Mulinacci N, Pinelli. P, Vincieri.F. F, Carlo M. Del, and Mascini M, “Comparison among Differential Pulse Voltammetry, Amperometric Biosensor, and HPLC/DAD Analysis for Polyphenol Determination” J. Agric. Food Chem. 2000; 48(4) : 1197–1203. Doi; https://doi.org/10.1021/jf990767e

Catriona Brian R, Hickey Eggins, Toft Stephen A , Zhou D. Min, “Determination of flavanols in beers with tissue biosensors” Anal. Chim. Acta, 1997; 347(3): 281-288. Doi: https://doi.org/10.1016/S0003-2670(97)00162-1

Leech Donal, Rechnitz Garry A, “Crayfish walking leg neuronal biosensor for the detection of pyrazinamide and selected local anesthetics” Anal. Chim. Acta, 1993; 274(1): 25-35. Doi: 10.1016/0003-2670(93)80601-g

Melzig Matthias F, Bader Gerd , Loose Renate, “Investigations of the Mechanism of Membrane Activity of Selected Triterpenoid Saponins” Planta Med, 2001; 67(1): 43-48.

DOI: https://doi.org/10.1055/s-2001-10632

Garippa Ralph J, Hoffman Ann F , Gradl Gabriele , Kirsch Achim, “[7] - High‐Throughput Confocal Microscopy for β‐Arrestin–Green Fluorescent Protein Translocation G Protein‐Coupled Receptor Assays Using the Evotec Opera” Methods Enzymol, 2006; 414: 99-120. Doi: https://doi.org/10.1016/S0076-6879(06)14007-0

Arenas M Yaiza, Cabrerea-Pastor Andrea, Juciute Nora, Mora-Navarro Eloy, Felipo Vicente, “Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway” J Neuroinflammation, 2020; 11;17(1) : 269. Doi: https://doi.org/10.1186/s12974-020-01941-y .

Zahn Martin , Renken Joachim , Seeger Stefan, “Fluorimetric multiparameter cell assay at the single cell level fabricated by optical tweezers” FEBS Lett, 1999; 443(3): 337-340. Doi: https://doi.org/10.1016/S0014-5793(98)01693-7

Jardemark K, Farre C, Jacobson I, Zare R N, Orwar, “Screening of receptor antagonists using agonist-activated patch clamp detection in chemical separations” Anal. Chem., 1998; 1;70(13): 2468-74. Doi: https://doi.org/10.1021/ac971147k .

Cesewski Ellen, N. Johnson Blake, “Electrochemical biosensors for pathogen detection” Biosens. Bioelectron, 2020; 159: 1-29. Doi: https://doi.org/10.1016/j.bios.2020.112214

Kaya Hüseyin Oğuzhan, E. Cetin Arif , Azimzadeh Mostafa, Topkaya Seda Nur, “Pathogen detection with electrochemical biosensors: Advantages, challenges and future perspectives” J. Electroanal. Chem, 2021; 882: 1-18. Doi: http://dx.doi.org/10.1016/j.jelechem.2021.114989

Raya Monalisa, Raya Asit , Dasha Swagatika , Mishraa Abtar , Acharyb K. Gopinath , Nayaka Sanghamitra , Singh Shikha, “Fungal disease detection in plants: Traditional assays, novel diagnostic techniques and biosensors” Biosens. Bioelectron, 2017; 87: 708-723. Doi: http://dx.doi.org/10.1016/j.bios.2016.09.032

Pinheiro Tomás , Cardoso A. Rita, E. A. Sousa Cristina, C. Marques Ana, Tavares Ana P. M., Matos Ana Miguel, Cruz Maria Teresa, T. C. Moreira Felismina, Martins Rodrigo, Fortunato Elvira, and F. Sales M. Goreti, “Paper-Based Biosensors for COVID-19: A Review of Innovative Tools for Controlling the Pandemic” ACS Omega, 2021; 6: 29268−29290. Doi: https://doi.org/10.1021/acsomega.1c04012

Gopinath P. G, Anitha V. R, and Mastani S. Aruna, “Microcantilever based Biosensor for Disease Detection Applications” J Med Biol Eng, 2015; 4: 307-311. Doi: doi: 10.12720/jomb.4.4.307-311

Vigneshvar Senthilkumaran, Senthilkumaran Balasubramanian, “Current technological trends in biosensors, nanoparticle devices and biolabels: Hi‐tech network sensing applications” Med. Devices Sens, 2018; 1: 1-14. Doi: https://doi.org/10.1002/mds3.10011

Byfield M.P, Abuknesha R. A, “Biochemical aspects of biosensors” Biosens. Bioelectron, 1994; 9(4-5): 373-399.Doi: https://doi.org/10.1016/0956-5663(94)80038-3

T. Nemane Shraddha, B. Gholve Sachin, G. Bhusnure Omprakash, T. Mule Shrikrishna, V. Ingle Priyanka, “Biosensors: An Emerging Technology in Pharmaceutical Industry” JDDT, 2019; 9(4): 643-647. Doi: http://dx.doi.org/10.22270/jddt.v9i4.3034

Published

2022-10-15
Statistics
Abstract Display: 482
PDF Downloads: 741
PDF Downloads: 36

How to Cite

1.
Kaur M, Sharma S, Kumar D. An insight into the multifarious applications of biosensors and the way forward. J. Drug Delivery Ther. [Internet]. 2022 Oct. 15 [cited 2026 Jan. 21];12(5-S):181-8. Available from: https://jddtonline.info/index.php/jddt/article/view/5633

How to Cite

1.
Kaur M, Sharma S, Kumar D. An insight into the multifarious applications of biosensors and the way forward. J. Drug Delivery Ther. [Internet]. 2022 Oct. 15 [cited 2026 Jan. 21];12(5-S):181-8. Available from: https://jddtonline.info/index.php/jddt/article/view/5633