Formulation and Characterization of Expandable Tablet of Diacerein using Swellable Polymers
Abstract
Some of the drugs have poor absorption because of a narrow absorption window in the gastrointestinal tract (GIT). To improve the absorption of such drugs in the GIT, gastro-retentive drug delivery techniques play an important role. Diacerein is an antirheumatic drug used for joint pain and arthritis. The expandable gastro-retentive tablets were prepared to attain an extended therapeutic action of Diacerein. Expandable tablets were formulated to prolong gastric retention, enhance the bioavailability of the drug candidate and attain a desirable size greater than the diametric size of the pyloric sphincter (i.e., 13 mm in diameter) of the tablet after administration by expandable technique. The expandable tablet was formulated using swellable polymers and polyelectrolytes, i.e., HPMCK 100, PEO, chitosan, and carbopol. The proposed expandable tablets were evaluated by preliminary evaluation parameters, micromeritic investigations, all physicochemical evaluations including swelling index, weight variation, drug content, in-vitro release studies and their release kinetics. Method: The wet granulation method is used for the preparation of expandable tablets of Diacerein. Result: The release of Diacerein from all formulations was studied in phosphate buffer pH 1.2 at 37±5°C. The net results conclude that the formulation having HPMC K 100, PEO with the addition of carbopol (formulation C1) showed the maximum swelling index as compared to others. And it was found that formulation C1 is the most superior and reliable formulation in terms of all physicochemical parameters and in-vitro drug release studies. The best formulation obtained from in-vitro drug release studies was shown.
Keywords: Gastro retentive, expandable system, noval drug delivery system, controlled drug delivery system, gastric transit time, swellable polymers, GIT.
Keywords:
Gastro retentive, expandable system, noval drug delivery system, controlled drug delivery system, gastric transit time, swellable polymers, GITDOI
https://doi.org/10.22270/jddt.v12i5.5612References
Davis SS, Formulation strategies for absorption window, Drug Discovery, 2005; 10:249-257 https://doi.org/10.1016/S1359-6446(04)03351-3
Chawla, G, Gupta P, Koradia V, Bansal A.K. Gastro retention a means to address regional variability in intestinal drug absorption, Pharma Technol, 2003; 50-68
Klausner EA, Lavy E, Friedman M, Hoffman, A Expandable gastro retentive dosage forms, Journal of controlled release, Elsevier, 2003; 90:143-162 https://doi.org/10.1016/S0168-3659(03)00203-7
Hwang S.J. Park, Gastric retentive drug delivery system, Crit. Rev the drug carrier Sys. 1998; 15:243-84 https://doi.org/10.1615/CritRevTherDrugCarrierSyst.v15.i3.20
Hamilton J.K., Polter D.E., Sleisenger M.H., Fordtran J.S., Gastrointestinal Disease, W.B. Saunders, Philadelphia, 1993; 1:286-292
Philip A, Badola A, Sah SK, Kumar R, Gastro retentive dosage forms for prolonging gastric residence time, International Journal of Pharmaceutical Medicine, 2007; 21:157-171 https://doi.org/10.2165/00124363-200721020-00005
Gupta P, Vermani K, Garg S, and Hydrogels: from controlled release to pH-responsive drug delivery, Drug Discover Today, 2002; 7 (10):569-79 https://doi.org/10.1016/S1359-6446(02)02255-9
Shivakumar HG, Gowda DV, Pramodkumar TM, Floating controlled drug delivery systems for prolonged gastric residence: a review, Ind J Pharm Edu, 2004; 38 (4):172-80
Thejaswini P, Suguna B, Sumalatha N, Umasankar K and Reddy P, Advanced Granulation Techniques for Pharmaceutical Formulations - Overview, International Journal of Research in Pharmaceutical and Nano Sciences, , 2013; 2(6):723 - 732
Shanmugam S, Granulation Techniques and Technologies: Recent Progresses, Bioimpacts, 2015; 5(1):55-63 https://doi.org/10.15171/bi.2015.04
Saravanan M, Kalakonda S, and Swaminath K, The Effect of Tablet Formulation and Hardness on in Vitro Release of Cephalexin from Eudragit L100 Based Extended Release Tablets, Department of Pharmaceutics, Vels College of Pharmacy, an Old Pallavaram Chennai-600117, Biol. Pharm. Bull, ,2002; 25(4):541-545 https://doi.org/10.1248/bpb.25.541
Chauhan B.S., Jaimini M, Sharma S and Bajaj R, Effect of Formulation Variables on the Swelling Index of Acyclovir Sustained Release Tablets Using Xanthan Gum and Sodium Alginate, Jaipur College of Pharmacy, Affiliated to Rajasthan University of Health Sciences, Jaipur, INDIA, Res. J. Pharmaceutical Sci, 2014; 3(1): 1-7
Yadav V, Jadhav P, Salunkhi P, Nikam P, Matkar S, Formulation and evaluation of gastro retentive tablets of antiulcer drug , Asian journal of pharmaceutical and clinical research, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, India, 2016; 9(6). DOI: https://doi.org/10.22159/ajpcr.2016.v9i6.10360
Reddy P and V, Bajjuri S, Sanka K, Jukanti R, Bandari S, RK Ajmeru, Potu AR, Formulation and Evaluation of Gastro retentive Dosage Form of Ofloxacin, Stamford journal or pharmaceutical sciences, 2011; 4(1):09-18
Published
Abstract Display: 488 
PDF Downloads: 468 PDF Downloads: 167 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.