Development and Characterization of novel bigel of loxoprofen for topical drug delivery
Abstract
Bigels are unique two-phase systems that have recently been presented as a structured method for active ingredient application. The purposes of the current study were to develop and characterize bigel formulations containing loxoprofen. They have the benefits of both hydrogel and organo-gel. In order to enhance penetration, pluronic lecithin was added to form the organo-gel, and HPMC was added to form the hydrogel, which properly hydrates the stratum corneum. Bigels were produced by mixing hydrogel with organo-gel in the appropriate ratio. pH, viscosity, extrudability, spreadability, and Gel-sol transition temperature were assessed for organo-gel and hydrogel. For the preparation of bigel, formulations O3 from organo-gel and H3 from hydrogel were characterized as optimum formulations. pH, viscosity, extrudability, spreadability, Gel-sol transition temperature, and other properties of the produced bigel were assessed. An 8-hour invitro drug release investigation yielded B1's results, which were 84.77%. B2 demonstrated 92.35 % release, B3 demonstrated 99.18% release, and bigel demonstrated extended-release. Based on evaluation characteristics, formulation B3 was chosen as the optimal formulation. Loxoprofen bigel release kinetics according to the Higuchi model. You can utilize loxoprofen bigel as an extended-release system.
Keywords: Loxoprofen, (B)Bigel Pluronic F127, (O)Organo-gel, HPMC, Gel-sol, (H)Hydrogel
Keywords:
Loxoprofen, Bigel Pluronic F127, Organo-gel, HPMC, Gel-sol, HydrogelDOI
https://doi.org/10.22270/jddt.v12i5.5579References
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