Anti-inflammatory, Analgesic, and Antipyretic Potential of Azadirachta indica: A Review

  • Sri Niza Oktavia Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147
  • Ifora Ifora Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147
  • fitra fauziah Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147


Inflammation is a protective response to injury or tissue damage and acts by eliminating harmful stimuli such as pathogens cell damage and initiates the healing process. Azadirachta indica was known as medicinal plant with various pharmacological activities. This review aims to summarize the scientific activity of A.indica as an anti-inflammatory, analgesic, and antipyretic with experimental models either in vivo or in vitro taken from several databases such as Google Scholar, ScienceDirect, and PubMed over the last ten years (2011- 2021). From the data, A.indica was proven to be anti-inflammatory by inhibiting pro-inflammatory cytokines such as IL-6, NFkB, COX2, IL-1, IL-6, TNF-α, IFN- γ, and reducing the volume of edema. Potential analgesic indicated by decreasing stomach writhing and reducing pain sensation in rats. The antipyretic activity was characterized by a decrease in rats' body temperature. This review proves that natural products from A.indica have anti-inflammatory, analgesic, and antipyretic potential.

Keywords: Analgesic, Azadirachta, Fever, Inflammation, Neem

Keywords: Analgesic, Azadirachta, Fever, Inflammation, Neem


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Author Biographies

Sri Niza Oktavia, Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147

Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147

Ifora Ifora, Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147

Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147

fitra fauziah, Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147

Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Sciences Padang (STIFARM Padang), West Sumatera, Indonesia, 25147


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How to Cite
Oktavia S, Ifora I, fauziah fitra. Anti-inflammatory, Analgesic, and Antipyretic Potential of Azadirachta indica: A Review. JDDT [Internet]. 15Jun.2022 [cited 1Jul.2022];12(3-S):245-54. Available from: