Evaluation of the antifungal powers of five plant species of the genus Terminalia on strains responsible for candidiasis
Abstract
Background: Candidiasis is a fungal disease caused by Candida albicans, a yeast that preferentially affects mucous membranes. These diseases are more and more recurrent because of the generalized decline in immunity and the appearance of resistance to classical antifungal drugs. Therefore, fighting against therapeutic failures becomes necessary. The objective of this study is to contribute to the fight against candidiasis through the research of new antifungal molecules. To do so, the hydroalcoholic extracts of Terminalia catappa, Terminalia glaucescens, Terminalia ivorensis, Terminalia mantaly and Terminalia superba, five plant species used in traditional medicine against dermatoses, were tested on the in vitro growth of resistant strains of Candida albicans. In addition, the polyphenol composition of these plants was carried out in order to evaluate their protective powers.
Methods: The antifungal tests were performed by the solid-state dilution method. While the determination of polyphenols was performed by the photometric method.
Results: The results showed an inhibition of the growth of germs by four plants except Terminalia catappa. The minimum inhibitory concentrations (MIC) obtained are as follows: MIC (T. ivorensis) =0.25 mg/mL; MIC (T. glaucescens) =0.50 mg/mL; MIC (T. superba) = 4 mg/ML; MIC (T. mantaly) = 2 mg/mL.
Conclusion: This study indicates that T. ivorensis is the most active and has the highest content of phenolic compounds. This plant could be a source of effective molecules in the treatment of candidiasis.
Keywords: Candida albicans, candidiasis, Terminalia, antifungal, polyphenol,
Keywords:
Candida albicans, candidiasis, Terminalia, antifungal, polyphenolDOI
https://doi.org/10.22270/jddt.v12i3-S.5370References
Bergogne-Bérézin E. Flores vaginales normales, vaginites et vaginoses bactériennes: diagnostic et thérapeutique. Antibiotiques, 2007 ; 9 :139-44. Doi : ANTI-05-2007-9-2-1294-5501-101019-200701945
Sobel JD. vulvovaginal candidosis. Lancet, 2007 ; 369:1961-71. DOI: https://doi.org/10.1016/S0140-6736(07)60917-9
Pihet M. et Marot A. Diagnostic biologique des candidoses. Revue Francophone des Laboratoires, 2013 ; 450:47–61. DOI: https://doi.org/10.1016/S1773-035X(13)71946-4
Djohan V., Angora K.E., Vanga-Bosson A.H., Konaté A., Kassi F.K., Yavo W., Kiki-Barro P.C., Menan H., Koné M. Sensibilité in vitro des souches de Candida albicans d’origine vaginale aux antifongiques à Abidjan (Côte d’Ivoire), Journal de Mycologie Médicale, 2012 ; 22(2) :129-133. DOI : https://doi.org/10.1016/j.mycmed.2011.11.005
Batawila K. Diversité, écologie et propriétés antifongiques des Combretaceae du Togo, Acta Botanica Gallica, 2002 ; 149 (4):515-516. DOI: https://doi.org/10.1080/12538078.2002.10515979
Ouattara S., Kra K.A.M., Kporou E. et Guede-Guina F.,. Évaluation de l’activité antifongique des extraits de Terminalia ivorensis (tekam 2) sur la croissance in vitro de aspergillus fumigatus. Bulletin de la société royale des sciences de liège, volume 2009; 78:302 – 310. DOI : https://popups.uliege.be/0037-9565/index.php?id=1590.
Yayé Y.G., Kra A.K.M., Ackah J.A.A.B. & Djaman A.J. Evaluation de l’activité antifongique et essai de purification des principes actifs des extraits de Terminalia mantaly (h.perrier), une combretacée, sur la croissance in vitro DE Candida albicans.», Bulletin de la Société Royale des Sciences de Liège, 2011; 80:953 – 964. DOI : https://popups.uliege.be/0037-9565/index.php?id=3480.
Ouattara Abou, Bolou Gbouhoury Eric-Kévin , Koffi Allali Eugène, Yasseu Hyacinthe, Ouattara Karamoko and Coulibaly Adama. Antifungal activity of Pericopsis (Afrormosia) laxiflora (Benth.) Bark on ringworm germs. Microbiology Research Journal International, 2020; 30(4):1-9. DOI: https://doi.org/10.9734/MRJI/2020/v30i430207
Fezan HT., N’guessan FK., Favel A. & Fallague K. Activité antifongique de quelques plantes de la flore ivoirienne. Sciences et Nature, 2007; 4(2):117-122. DOI: https://doi.org/10.4314/scinat.v4i2.42136
Ahon Gnamien Marcel. Evaluation et essai d’optimisation de l’activite antifongique des extraits de Terminalia superba Engl & Diels (Combretaceae) SUR LA CROISSANCE in vitro DE Aspergillus fumigatus, Candida albicans et Cryptococcus neoformans, thèse de doctorat unique, université FHB, Côte d’ivoire, 2014, 117 pages.
Thès PM. Recherche du profil antimicrobien des huiles de G243 et MISCA sur quelques agents de mycose de la peau, Mémoire de DEA de biotechnologies, option pharmacologie microbiologie. Université de Cocody, Côte-d’Ivoire, 2001 ; 34p.
Bagré, I., Bahi, C., Ouattara K., Zirihi GN., Djaman AJ., Coulibaly A., N'Guessan JD. Étude botanique et exploration de l'activité antifongique de Morinda morindoides (Baker) Milne-Redh. sur la croissance in vitro de Cryptococcus neoformans. Phytothérapie, 2011; 9:136-141. DOI : https://doi.org/10.1007/s10298-011-0612-y
Kra A. K. M. (2001). Evaluation et amélioration par séquençage chromatographique d’une action fongique de MISCA contre Aspergillus fimugatus, Thèse 3e cycle, Université de Cocody. Abidjan, 2001, 126p.
Djamilatou Z.S., Djibo A.K. Sahabi B. & Seini S.H. (2021). Screening phytochimique, dosage des polyphénols et détermination de l’activité antioxydante de deux plantes anti-hypertensives du Niger. European Scientific Journal, 2021; 17(17) :335. DOI: https://doi.org/10.19044/esj.2021.v17n17p335
Kouamé T.K, Sorho S., Kassi A.B.B. et Yaya Soro Y. Détermination des teneurs en polyphénols totaux, flavonoïdes totaux et tanins de jeunes feuilles non encore ouvertes de Piliostigma thonningii (Caesalpiniaceae). Int. J. Biol. Chem. Sci. 2021; 15(1):97-105. DOI : https://doi.org/10.4314/ijbcs.v15i1.9
Moomin, A., Mensah, K.B., Forkuo, A., Adu-Gyamfi, P.K.T. And Ansah, C. Ethanolic stem bark extract of terminalia ivorensis A. Chev. protects against potassium dichromate-induced nephrotoxicity in rats. Scientific African, 2020 ; 8, 10p. DOI : https://doi.org/10.1016/j.sciaf.2020.e00410
Angaman R.K., Abo K., Orsot B.M.A.B., Ouattara D., Zirihi N.G. Evaluation de l’activité antifongique in vitro et in vivo d’extraits de Terminalia ivorensis et Terminalia superba sur Fusarium oxysporum. Journal Of Humanities And Social Science, 2020; 25(3):11-18. DOI: https://doi.org/10.9790/0837-2503081118
Soumahoro I.A., D’almeida K.M.A, Gnahoue G., Kra A.K.M., Djaman A.J. evaluation of ointment activity based on terminalia mantaly extract. journal of drug delivery & therapeutics. 2016; 6(5):41-45. DOI: http://dx.doi.org/10.22270/jddt.v6i5.1314
Angaman R.K., Abo K., Ouattara D., Zirihi N.G. Formulation d’un biofongicide à partir d’extraits de Terminalia superba et Terminalia ivorensis et évaluation de son activité antifongique in vitro et in vivo sur phytophtora capsici et Fusarium oxysporum. Journal of Applied Biosciences, 2020; 146:15005-15015. DOI : https://doi.org/10.35759/JABs.v146.3
Ouattara S., N’Guessan C. D.R, Bagré I, Kporou K. E., Kra A.K.M. Djaman A.J. (2020). Formulation of an Ointment from Hydroethanolic Extract of Terminalia ivorensis and Therapeutic Trial on Volunteers with Moths. J. Nat. Prod. Resour, 2020; 6 (2):262–264. DOI : https://doi.org/10.30799/jnpr.093.20060202
Awa, D., Konan, Y., Youssouf, S., Honora, T. B. F., Adama, B., & Witabouna, K. M. Pouvoir antioxydant et teneurs en composés phénoliques de deux espèces du genre Albertisia: Albertisia cordifolia (Mangenot & J. Miège) Forman et Albertisia scandens (Mangenot & J. Miège) Forman (Menispermaceae). European Scientific Journal, ESJ, 2018; 14(30):128. Doi: https://doi.org/10.19044/esj.2018.v14n30p128
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