A Case Report on Multiple Adverse Events Associated with Systemic Usage of Dexamethasone
Abstract
Dexamethasone is a corticosteroid used in the management of various allergic conditions, inflammatory and autoimmune disorders such as rheumatoid arthritis, nausea and vomiting associated with cancer chemotherapy, multiple sclerosis, cerebral edema. ADRs associated usage of corticosteroids includes steroid-induced hyperglycemia, osteoporosis, dyslipidemia, steroid-induced Cushing syndrome, cataracts, increased risk of infections, and thinning of the skin. Cushing's syndrome is a hormonal disorder triggered due to chronic exposure of body tissues to high levels of cortisol. As corticosteroids are widely used by physicians for the management of various inflammatory disorders, patients must be warned about the possible ADRs associated with chronic use. In summary, this is a case of a patient who developed multiple adverse events after usage of dexamethasone that is evident by clinical features and laboratory investigations for which the patient was successfully provided with symptomatic and supportive care.
Keywords: Adverse Drug Reaction (ADR), Buffalo hump, Hyperglycaemia, Osteoporosis.
Keywords:
Adverse Drug Reaction (ADR), Buffalo hump, Hyperglycaemia, OsteoporosisDOI
https://doi.org/10.22270/jddt.v12i6.5277References
Siddarama R, Reddy YH, Reddy GA. A case report on steroid induced Cushing syn-drome and NSAID induced bronchial asthma. IAJPR. 2015; 5(4):1404-07.
Ha Y, Lee KH, Jung S, Lee SW, Lee SK, Park YB. Glucocorticoid-induced diabetes mellitus in patients with systemic lupus erythematosus treated with high-dose gluco-corticoid therapy. Lupus. 2011 Oct; 20(10):1027-34. https://doi.org/10.1177/0961203311402246
Schäcke H, Döcke WD, Asadullah K. Mechanisms involved in the side effects of glu-cocorticoids. Pharmacol Ther. 2002 Oct; 96(1):23-43. https://doi.org/10.1016/S0163-7258(02)00297-8
Wisse B, Zieve D, Black B. Cushing syndrome - exogenous. US national library of medicine. American Accreditation HealthCare Commission.
Suh S, Park MK. Glucocorticoid-Induced Diabetes Mellitus: An Important but Overlooked Problem. Endocrinol Metab (Seoul). 2017 Jun; 32(2):180-189. https://doi.org/10.3803/EnM.2017.32.2.180
Canalis E. Clinical review 83: Mechanisms of glucocorticoid action in bone: implica-tions to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab. 1996; 81(10):3441-3447. https://doi.org/10.1210/jc.81.10.3441
Akeno N, Matsunuma A, Maeda T, Kawane T, Horiuchi N. Regulation of vitamin D-1alpha-hydroxylase and -24-hydroxylase expression by dexamethasone in mouse kidney. J Endocrinol. 2000 Mar; 164(3):339-48. https://doi.org/10.1677/joe.0.1640339
Dhawan P, Christakos S. Novel regulation of 25-hydroxyvitamin D3 24-hydroxylase (24(OH)ase) transcription by glucocorticoids: cooperative effects of the glucocorticoid receptor, C/EBP beta, and the Vitamin D receptor in 24(OH)ase transcription. J Cell Biochem. 2010 Aug 15; 110(6):1314-23. https://doi.org/10.1002/jcb.22645
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