A Review on medicinal plants in dentistry

Authors

  • Omji Porwal Department of Pharmacognosy, Faculty of pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq
  • Duran Kala Department of Pharmacognosy, Faculty of pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq

Abstract

The dental afflictions are indubitably the most important global infectious diseases affecting both children and adults. The most significant dental illness is dental caries and periodontal pathologies. The major reason of oral health troubles is more inhabitants with pathogenic bacteria and for this reason, conservative treatment can often be in efficient because of bacterial resistance or may have unpleasant side effects.For that reason, studies in the field have focused on finding new therapeutic alternatives.The use of natural medicines for dental care is an ancient cross-cultural practice that persists in the majority of cultures today.Over the past decade, interest in drugs derived from medicinal plants has markedly increased. This study was designed at a literature review focusing on studies investigating herbal drugs and their therapeutic application, mechanism of action, side effects, toxicities and probable drug interactions. A small number of studies were established to hold their rational employ in dentistry. Because there is a rising employ of phytotherapeutic agents in dentistry, additional studies are required to evaluate their safety and efficacy for clinical use.

Keywords: Herbal medicine, Oral health, Dentistry, Caries, Infections

Keywords:

Herbal medicine, Oral health, Dentistry, Caries, Infections

DOI

https://doi.org/10.22270/jddt.v11i6.5128

Author Biographies

Omji Porwal, Department of Pharmacognosy, Faculty of pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq

Department of Pharmacognosy, Faculty of pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq

Duran Kala, Department of Pharmacognosy, Faculty of pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq

Department of Pharmacognosy, Faculty of pharmacy, Tishk International University-Erbil, Kurdistan Region, Iraq

References

Palombo EA. Traditional medicinal plant extracts and natural products with activity against oral bacteria: potential application in the prevention and treatment of oral diseases. Evid Based Complement Alternat Med 2011; 2011:680354. https://doi.org/10.1093/ecam/nep067

Porwal O, Singh SK, Patel DK, Gupta S, Tripathi R, Katekhaye S. Cultivation, Collection and Processing of Medicinal Plants. Bioactive Phytochemicals: Drug Discovery to Product Development. 2020:14-30. https://doi.org/10.2174/9789811464485120010005

Ramanunny AK, Wadhwa S, Gulati M, Gupta S, Porwal O, Jha NK, et al., Development and validation of RP-HPLC method for 1΄-Acetoxychavicol acetate (ACA) and its application in optimizing the yield of ACA during its isolation from Alpiniagalanga extract as well as its quantification in nanoemulsion. S Afr J Bot 2021. https://doi.org/10.1016/j.sajb.2021.10.012

Oncag O, Cogulu D, Uzel A, Sorkun K. Efficacy of propolis as an intracanal medicament against Enterococcus faecalis. Gen Dent 2006; 54:319-322.

Sood A, Kumar B, Singh SK, Prashar P, Gautam A, Gulati M, et al., Flavonoids as potential therapeutic agents for the management of diabetic neuropathy. Curr Pharma Des 2020; 26(42):5468-5487. https://doi.org/10.2174/1381612826666200826164322

Singh S, Singh SK, Kumar B, Kaur B, Khursheed R, Gulati M, et al., Effect of co-administration of herbal extracts with copper nanoparticles: a novel two-pronged approach in treating type 2 diabetes. Recent Innov Chem Eng2020; 13(5):366-378. https://doi.org/10.2174/2405520413999200719140819

Banerjee M, Khursheed R, Yadav AK, Singh SK, Gulati M, Pandey DK, et al., A systematic review on synthetic drugs and phytopharmaceuticals used to manage diabetes. Curr Diabetes Rev 2020; 16(4):340-356. https://doi.org/10.2174/1573399815666190822165141

Porwal O, Nanjan MJ, Chandrasekar MJN, Srinivasan R, Gupta S. Anticancer potential of solanumjasminoides. Int J Pharm Sci Res 2014; 5(9):3768-3774.

Chandrasekar MJN, Srinivasan R, Porwal O, Nanjan MJ. In-Vitro antioxidant activity of solanum jasminoides paxt extracts. J Nat Remedies. 2012; 12(2):115-118.

Vishwas S, Gulati M, Kapoor B, Gupta S, Singh SK, Awasthi A, et al., Expanding the arsenal against Huntington's disease-Herbal drugs and their nanoformulations. Curr Neuropharmacol 2021; 19(7):957-989. https://doi.org/10.2174/1570159X18666201109090824

Malviya R, Raj S, Fuloria S, Subramaniyan V, Sathasivam K, Kumari U, et al., Evaluation of antitumor efficacy of chitosan-tamarind gum polysaccharide polyelectrolyte complex stabilized nanoparticles of simvastatin. Int J Nanomed 2021; 16:2533-2553. https://doi.org/10.2147/IJN.S300991

Kabra P, Loomba K, Kabra SK, Majumdar DSP, Kumar N. Medicinal plants in the treatment of dental caries. Asian J Oral Health Allied Sci 2012; 2(1): 12-16.

Calixto JB. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz J Med Biol Res 2000; 33:179-189. https://doi.org/10.1590/S0100-879X2000000200004

Petersen PE. The World Oral Health Report 2003: continuous improvement of oral health in the 21st century-the approach of the WHO Global Oral Health Program Community Dentistry and Oral Epidemiology 2003; 31(1):3-24. https://doi.org/10.1046/j..2003.com122.x

Hussain FHS, Amin HIM, Patel DK, Porwal O. An overview of the therapeutic potential of Iris persica. Curr Tradit Med 2021; 7(2):152-160. https://doi.org/10.2174/2215083806666200117111320

Porwal O, Gupta S, Nanjan MJ, Singh A. Classical taxonomy studies of medicinally important Ipomoea leari. Ancient science of life. 2015; 35(1):34. https://doi.org/10.4103/0257-7941.165628

Petersen P, Kwan S. The 7 (Th) WHO Global Conferences on Health Promotion-towards Integration of Oral Health (Nairobi, Kenya 2009). Community Dent Health 2021; 26:1109.

Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. The global burden of oral diseases and risks to oral health bull. World Health Organ 2005; 83:661-669.

Jenkinsonand HF, Lamont RJ. Oral microbial communities in sickness and in health. Trends Microbiol 2005; 13(12):589-95. https://doi.org/10.1016/j.tim.2005.09.006

Rodrigues F, Lehmann M, do Amaral VS, Reguly ML, de Andrade HHR. Genotoxicity of three mouthwash products, cepacol, periogard, and plax, in the drosophila wing-spot test environ. Mol Mutagen 2007, 48,:644-649. https://doi.org/10.1002/em.20332

Taheri JB, Azimi S, Rafieian N, Akhavan Zanjani H. Herbs in dentistry. Int Dent J 2011; 61:287-296. https://doi.org/10.1111/j.1875-595X.2011.00064.x

Babaeekhou L, Ghane M. Antimicrobial activity of ginger on cariogenic bacteria: molecular networking and molecular docking analyses. J Biomol Struct Dyn 2020; 1-12. https://doi.org/10.1080/07391102.2020.1745283

Hagh LG, Arefian A, Farajzade A, Dibazar S, Samiea N. The antibacterialactivity of "Saturejahortensis" extract and essential oil against oral bacteria. Dent Res J 2019; 16:153-159. https://doi.org/10.4103/1735-3327.255741

Shahriari S, Barekatain M, Shahtalebi MA, Farhad SZ, Evaluation of preventive antibacterial properties of Glass-ionomer cement containing purified powder of salvia officinalis: an invitro study. Int J Prev Med 2019; 10:110. https://doi.org/10.4103/ijpvm.IJPVM_81_17

Shaheena S, Chintagunta AD, Dirisala VR, Sampath Kumar NS. Extraction of bioactive compounds from Psidium guajava and their application in dentistry. Amb Express 2019; 9:208. https://doi.org/10.1186/s13568-019-0935-x

Kokubu E, Kinoshita E, Ishihara K. Inhibitory effects of Lingon berry extracts on oral streptococcal biofilm formation and bioactivity. Bull Tokyo Dent Coll 2019; 60:1-9. https://doi.org/10.2209/tdcpublication.2018-0007

Agarwal S, Ramamurthy PH, Fernandes B, Rath A, Sidhu P. Assessment of antimicrobial activity of different concentrations of Tinospora cordifolia against Streptococcus mutans: an invitro study. Dent Res J 2019; 16:24-28. https://doi.org/10.4103/1735-3327.249556

Bhadoria N, Gunwal MK, Suryawanshi, H, Sonarkar SS. Antiadherence and antimicrobial property of herbal extracts (Glycyrrhiza glabra and Terminalia chebula) on Streptococcus mutans: an invitro experimental study. J OralMaxillofc Pathol 2019; 23:73-77.

Dadpe MV, Dhore SV, Dahake PT, Kale YJ, Kendre SB, Siddiqui AG. Evaluation of antimicrobial efficacy of Trachyspermum ammi (Ajwain) oil and chlorhexidine against oral bacteria: an in vitro study. J Indian Soc Pedod Prev Dent 2018; 36: 357-363. https://doi.org/10.4103/JISPPD.JISPPD_65_18

Raghavan R, Devi MPS, Varghese M, Joseph A, Madhavan SS, Sreedevi PV. Effectiveness of Mentha piperita leaf extracts against oral pathogens: an in vitro study. J Contemp Dent Pract 2018; 19: 1042-1046. https://doi.org/10.5005/jp-journals-10024-2378

Melok AL, Lee LH, MohamedYussof SA, Chu T. Green tea polyphenol epigallocatechin-3-gallate-stearate inhibits the growth of Streptococcus mutans: a promising new approach in caries prevention. Dent J 2018; 6 (3):38. https://doi.org/10.3390/dj6030038

Kim S, Lee S, Lee H, Ha J, Lee J, Choi Y. et al., Evaluation on antimicrobial activity of psoraleae semen extract controlling the growth of gram-positive bacteria. Korean J Food Sci Anim Resour 2017; 37:502-510. https://doi.org/10.5851/kosfa.2017.37.4.502

Millo G, Juntavee A, Ratanathongkam A, Nualkaew N, Peerapattana J, Chatchiwiwattana S. Antibacterial inhibitory effects of Punicagranatum gel on cariogenic bacteria: an in vitro study. Int J Clin Pediatr Dent 2017; 10:152-157. https://doi.org/10.5005/jp-journals-10005-1426

Zhang TT, Guo .J, Liu XJ, Chu JP, Zhou XD. Galla chinensis compounds remineralize enamel caries lesions in a rat model. Caries Res 2016; 50(2):159-65. https://doi.org/10.1159/000445036

Valones MA, Higino, J. S, Souza PR, Crovella S, Caldas AFJ, Carvalho AA. Dentifrice containing extract of Rosmarinus officinalis Linn. An antimicrobial evaluation. Braz Dent J 2016; 27:497-501. https://doi.org/10.1590/0103-6440201600672

Jain S, Rathod N, Nagi R, Sur J, Laheji A, Gupta N. et al., Antibacterial effect of aloe vera gel against oral pathogens: anin-vitro study. J Clin Diagn Res 2016; 10:Zc41-zc44. https://doi.org/10.7860/JCDR/2016/21450.8890

Sekita Y, Murakami K, Yumoto H, Amoh T, Fujiwara N, Ogata S et al., Preventive effects of Houttuynia cordata extract for oral infectious diseases. Bio Med Res Int 2016; 2581876. https://doi.org/10.1155/2016/2581876

Yang Y, Liu S, He Y, Chen Z, Li M. Effect of Long Zhang Gargle on biofilm formation an dacidogenicity of Streptococcus mutans invitro. Bio Med Res Int 2016; 5829823. https://doi.org/10.1155/2016/5829823

Wittpahl G, Kolling-Speer I, Basche S, Herrmann E, Hannig M, Speer K, Hannig C. The polyphenolic composition of Cistus incanus herbal tea and its antibacterial and anti-adherent activity against Streptococcus mutans. Planta Med 2015; 81:1727-1735. https://doi.org/10.1055/s-0035-1557822

Thomas A, Thakur S, Mhambrey S. Comparison of the antimicrobial efficacy of chlorhexidine, sodium fluoride, fluoride with essential oils, alum, green tea, and garlic with limem out hrinseson cariogenic microbes. J Int Soc Prev Community Dent 2015; 5:302-308. https://doi.org/10.4103/2231-0762.161759

Anand G, Ravinanthan M, Basaviah R, Shetty AV. Invitro antimicrobial and cytotoxic effects of Anacardium occidentale and Mangifera indica in oral care. J Pharm Bio Allied Sci 2015; 7:69-74. https://doi.org/10.4103/0975-7406.148780

Chang AM, Bamashmous S, Darveau RP, Rajapakse S. An Ayurvedic herbal extract inhibits oral epithelial cell IL-8 responses to host and bacterial agonists. BMC Complement Med Ther 2020; 20:62. https://doi.org/10.1186/s12906-020-2850-8

Smida I, Pentelescu C, Pentelescu O, Sweidan A, Oliviero N, Meuric V, et al., Tamanai-benefits of seabuckthorn (Hippophaerhamnoides) pulp oil-based mouth wash on oral health. J Appl Microbiol 2019; 126:1594-1605. https://doi.org/10.1111/jam.14210

Saquib SA, AlQahtani NA, Ahmad I, Kader MA, Al Shahrani SS, Asiri EA. Evaluation and comparison of antibacterial efficacy of herbal extracts in combination with antibiotics on periodontal pathobionts: an in vitro microbiological study. Antibiotics (Basel) 2019; 8. https://doi.org/10.3390/antibiotics8030089

ChandraShekar B R, Nagarajappa R, Jain R, Singh R, Suma S, Thakur R. Antimicrobial Efficacy of Acacia nilotica, Murrayakoenigii L. Sprengel, Eucalyptus hybrid, Psidium guajava extracts and their combinations on Fusobacteriumnucleatum and Porphyrom on as gingivalis. Indian J Dent Res 2018; 29:641-645. https://doi.org/10.4103/ijdr.IJDR_52_17

Pakdel F, Ghasemi S, Babaloo A, Javadzadeh Y, Momeni R, Ghanizadeh M, et al., Antibacterial effects of garlic extracts and Ziziphora essential oil on bacteria associated with peri-implantitis. J Clin Diagn Res 2017; 11:Zc16-zc19. https://doi.org/10.7860/JCDR/2017/24786.9620

Sekita Y, Murakami K, Yumoto H, Hirao K, Amoh T, Fujiwara N, Hirota K, et al., Antibio film and anti-inflammatory activities of Houttuynia cordata decoction for oral care. Evid Based Complement Alternat Med 2017; 2850947. https://doi.org/10.1155/2017/2850947

Chin YT, Hsieh MT, Lin CY, Kuo PJ, Yang YC, Shih YJ, et al., 2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-glucoside isolated from polygoni multiflori ameliorates the development of periodontitis. Mediat Inflamm 2016; 6953459, 2016. https://doi.org/10.1155/2016/6953459

Gunjal S, Ankola AV, Bhat K. Invitro antibacterial activity of ethanolic extract of Morusalba leaf against periodontal pathogens. Indian J Dent Res 2015; 26:533-536. https://doi.org/10.4103/0970-9290.172082

Gennaro G, Claudino M, Cestari TM, Ceolin D, Germino P, Garlet GP, deAssis GF. Green tea modulates cytokine expression in the periodontiumand attenuates alveolar bone resorptionin type 1 diabetic rats. PloS One 2015; 10:e0134784. https://doi.org/10.1371/journal.pone.0134784

Shrestha B, Theerathavaj ML, Thaweboon S, Thaweboon B. In vitro antimicrobial effects of grape seed extract on peri-implantitis microflora in craniofacial implants. Asian Pac J Trop Biomed 2012; 2:822-825. https://doi.org/10.1016/S2221-1691(12)60236-6

Raoof M, Khaleghi M, Siasar N, Mohannadalizadeh S, Haghani J, Amanpour S. ,Antimicrobial activity of methanolic extracts of myrtus communis L. And Eucalyptus Galbie and their combination with calcium hydroxide powder against Enterococcus faecalis. J Dent 2019; 20195:-202.

Shi Y, Deng Z, Yang Y, Cui L, Chen T, Hu M. et al., Evaluation of sodium hypochlorite irrigant, bingpeng irrigant, and fufang bingpeng irrigant as endodontic irrigants during passive ultrasonic irrigation. Front Cell Infect Microboil 2019; 9:145. https://doi.org/10.3389/fcimb.2019.00145

Susan AC, Bharathraj AR, Praveen M, Kumar NSM, Karunakaran JV. Intra radicular smear removal efficacy of triphala final rinse solution in curved canals: a scanning electron microscope study. J Pharm Bio Allied Sci 2019; 11:S420-s428. https://doi.org/10.4103/JPBS.JPBS_55_19

Singh M, Singh S, Salgar A R, Prathibha N, Chandrahari N, Swapna LA. An invitro comparative evaluation of antimicrobial efficacy of Propolis, Morinda cordifolia juice, sodium hypochlorite and chlorhexidine on Enterococcusfaecalis and Candida albicans. J Contemp Dent Pract 2019; 20:40-45. https://doi.org/10.5005/jp-journals-10024-2473

Pradhan MS, Gunwal M, Shenoi P, Sonarkar S, Bhattacharya S, Badole G. Evaluation of pH and chlorine content of a novel herbal sodium hypochlorite for rootcanal disinfection: an experimental in vitro study. Contemp Clin Dent 2018; 9:S74-s78. https://doi.org/10.4103/ccd.ccd_60_18

Noushad MC, Balan B, Basheer S, Usman SB, Muhammed Askar MK. Antimicrobial efficacy of different natural extracts against persistent root canal pathogens: an in vitro study. Contemp Clin Dent 2018; 9:177-181. https://doi.org/10.4103/ccd.ccd_754_17

Choudhary E, Indushekar KR, Saraf BG, Sheoran N, Sardana D, Shekhar A. Exploring the role of Morinda citrifolia and triphala juice in root canal irrigation: anexvivostudy.JConservDent 2018; 21:443-449. https://doi.org/10.4103/JCD.JCD_58_18

Vasudeva A, Sinha DJ, Tyagi SP, Singh NN, Garg P, Upadhyay D. Disinfection of dentinal tubules with 2% Chlorhexidine gel, Calcium hydroxide and herbal intracanalmedicaments against Enterococcus faecalis: anin-vitrostudy. Singapore Dent J 2017; 38:39-44. https://doi.org/10.1016/j.sdj.2017.06.001

Makade CS, Shenoi PR, Morey E, Paralikar AV. Evaluation of antimicrobial activity and efficacy of herbal oils and extracts in disinfection of gutta-percha cones before obstruction. Restor Dent Endod 2017; 42:264-272. https://doi.org/10.5395/rde.2017.42.4.264

Dubey S. Comparative antimicrobial efficacy of herbal alternatives (Emblica officinalis, Psidium guajava), MTAD, and 2.5% sodium hypochlorite against Enterococcus faecalis: an in vitro study. J Oral Biol Craniofac Res 2016; 6:45-48. https://doi.org/10.1016/j.jobcr.2015.12.010

Babaji P, Jagtap K, Lau H, Bansal N, Thajuraj S, Sondhi P. Comparative evaluation of antimicrobial effect of herbal root canalirrigants (Morinda citrifolia, Azadirachta indica, Aloe vera) with sodium hypochlorite: an in vitro study. J Int Soc Prev CommunityDent 2016; 6:196-199. https://doi.org/10.4103/2231-0762.183104

Birring OJ, Viloria IL, Nunez P. Anti-microbial efficacy of Allium sativum extract against Enterococcusfaecalis biofilm and its penetration into the root dentin: an invitro study. Indian J Dent Res 2015; 26:477-482. https://doi.org/10.4103/0970-9290.172041

Abbaszadegan A, Gholami A, Mirhadi H, Saliminasab M, Kazemi A, Moein MR. Antimicrobial and cytotoxic activity of Ferula gummosa plant essential oil compared to NaOCl and CHX: a preliminary invitro study. Restor Dent Endod 2015; 40:50-57. https://doi.org/10.5395/rde.2015.40.1.50

Ariamanesh H, Tamizi N, Yazdinezhad A, Salah S, Motamed N, Amanloo S. The effectiveness of Nigella sativa alcoholic extract on the inhibition of Candida albicans colonization and formation of plaque on acrylic denture plates: an invitro study. J Dent 2019; 20:171-177.

Almeida NLM, Saldanha LL, daSilva RA, Pinke KH, daCosta EF, PortoVC, Dokkedal AL, Lara VS. Antimicrobial activity of denture adhesive associated with Equisetum giganteum and Punica granatum-enriched fractions against Candida albicans biofilms on acrylicresin surfaces. Bio fouling 2018; 34:62-73. https://doi.org/10.1080/08927014.2017.1407408

Li JX, Li QJ, Guan YF, Song X, Liu YH, Zhang JJ, et al., .Discovery of antifungal constituents from the Miao medicinal plant Isodon flavidus. J. Ethnopharmacol 2016; 191:372378. https://doi.org/10.1016/j.jep.2016.06.046

Ghasempour M, Omran SM, Moghadamnia AA, Shafiee F. Effect of aqueous and ethanolic extracts of Lippiacitriodora on candida albicans. Electron Physician 2016; 8:2752-2758. https://doi.org/10.19082/2752

Aghazadeh M., Zahedi Bialvaei A, Aghazadeh M, Kabiri F, Saliani N, Yousefi M, Eslami H, SamadiKafil H. Survey of the antibiofilm and antimicrobial effects of zingiber officinale (in vitro study). Jundishapur J Microbiol 2016; 9: e30167. https://doi.org/10.5812/jjm.30167

Aghili H, JafariNadoushan AA, Herandi V. Antimicrobial effect of zataria multiflora extract in comparison with chlorhexidine mouth wash on experimentally contaminated orthodontic elastomeric ligatures. J Dent 2016; 12:1-10.

Srivatstava A, Ginjupalli K, Perampalli NU, Bhat N, Ballal M. Evaluation of the properties of a tissue conditioner containing origanum oil as an antifungal additive. J Prosthet Dent 2013; 110:313-319. https://doi.org/10.1016/S0022-3913(13)60381-9

Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, et al., The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis. Sci Rep 2020; 10:625. https://doi.org/10.1038/s41598-019-57192-2

Kim JS, Yi HK. SchisandrinC enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms. Naunyn-Schmiedeberg's Arch Pharmacol 2018; 391:197-206. https://doi.org/10.1007/s00210-017-1449-1

Zaheer N, Shahbaz M, Athar Y, Arshad AI, Zaheer U, Alam, MK. Role of green tea extract (Camellia sinensis) in prevention of nicotine induced vascular changes in buccal mucosa of albino rats. Int Med J 2017; 24:120-125.

Yeh CM, Hsieh MJ, Yang JS, Yang SF, Chuang YT, Su SC, et al., Gerani in inhibits oral cancer cell migration by suppressing matrix met alloproteinase-2 activation through the FAK/Src and ERK pathways.EnvironToxicol2019;34:1085-1093. https://doi.org/10.1002/tox.22809

Pouyfung P, Choonate S, Wongnoppavich A, Rongnoparut P, Chairatvit K, Anti-proliferative effect of 8 alpha-tigloyloxyhirsutinolide-13-O-acetate (8alphaTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation. Phytomedicine 2019; 52:238-246. https://doi.org/10.1016/j.phymed.2018.09.211

Ezhilarasan, D, Apoorva VS, Ashok Vardhan N. Syzygium cumini extract induced reactive oxygen species-mediated apoptosis in humanoral squamous carcinoma cells. J Oral Pathol Med 2019; 48:115-121. https://doi.org/10.1111/jop.12806

Liao MY, Chuang CY, Hsieh MJ, Chou YE, Lin CW, Chen WR, et al., Antimetastatic effects of Eclipta prostrata extract on oral cancer cells. Environ Toxicol 2019; 33:923-930. https://doi.org/10.1002/tox.22577

Chen YY, Hsieh MJ, Hsieh YS, Chang YC, Chen PN, Yang SF, et al., Antimetastatic effects of Rheum palmatum extract on oral cancer cells. Environ Toxicol 2017; 32:2287-2294. https://doi.org/10.1002/tox.22444

Amjed S, Junaid K, Jafar J, Amjad T, Maqsood W, Mukhtar N, et al., Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens & anti-proliferative activity against cancer cell line. BMC Compl Alternative Med 2017; 17:265. https://doi.org/10.1186/s12906-017-1778-0

Yang CY, Hsieh CC, Lin CK, Lin CS, Peng B, Lin GJ, et al., Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells. BMC Compl Alternative Med 2017; 17:555. https://doi.org/10.1186/s12906-017-2063-y

Lu KW, Ma YS, Yu FS, Huang YP, Chu YL, et al., Gypenosides induce cell death and alter gene expression in human oral cancer HSC-3 cells. Exp Ther Med 2017; 14: 2469-2476. https://doi.org/10.3892/etm.2017.4840

Lee HJ, Jue SS, Kang SK, Bae WJ, Kim YC, Kim EC. Cudra xanthone H induces growth inhibition and apoptosis in oral cancer cells via NF-kappa B and PIN1 pathways. Am J Chin Med 2015; 43:1439-1452. https://doi.org/10.1142/S0192415X15500810

Ozyurt A, Elmas C, Seymen CM, Peker VT, Altunkaynak B, Gungor MN. Effects of low-level laser therapy with an herbal extract on alveolar bone healing. J Oral Maxillofac Surg 2018; 76:287. https://doi.org/10.1016/j.joms.2017.10.014

Gu H, Boonanantanasarn K, Kang M, Kim I, Woo KM, Ryoo HM, Baek JH. Morinda citrifolia leaf extract enhances osteogenic differentiation through activation of wnt/beta-catenin signaling. J Med Food 2018; 21:57-69. https://doi.org/10.1089/jmf.2017.3933

Boonyagul S, Banlunara W, Sangvanich P, Thunyakitpisal P. Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model. Odontology 2018; 102:310-317. https://doi.org/10.1007/s10266-012-0101-2

Malviya R, Sundram S, Fuloria S, Subramaniyan V, Sathasivam KV, Azad AK, et al., evaluation and characterization of tamarind gum polysaccharide: The Biopolymer. Polymers 2021; 13(18):3023. https://doi.org/10.3390/polym13183023

Porwal O, Malviya R, Ameen MSM, Anwar ET, Sharma A. A review on effect of various parameters on the rheological behaviour, thermal properties and viscosity of potato starch. Curr Materials Sci 2021; E-pub Ahead of Print. https://doi.org/10.2174/2666145414666210521214130

Kaur G, Singh SK, Kumar R, Kumar B, Kumari Y, Gulati M, et al., Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis. J Drug Del Sci Tech 2020; 60:1-10. https://doi.org/10.1016/j.jddst.2020.101980

Som S, Singh SK, Khatik GL, Kapoor B, Gulati M, Kuppusamy G, et al., Quality by design-based crystallization of curcumin using liquid antisolvent precipitation: micromeritic, biopharmaceutical, and stability aspects. Assay Drug Develop Tech2020; 18(1):11-33. https://doi.org/10.1089/adt.2018.913

Fatima N. Toxic effects as a result of herbal medicine intake. Toxicology-New Aspects to This Scientific Conundrum. 2016, pp193-207. https://doi.org/10.5772/64468

Malviya R, Jha S, Fuloria NK, Subramaniyan V, Chakravarthi S, Sathasivam K, et al., determination of temperature-dependent coefficients of viscosity and surface tension of tamarind seeds (Tamarindus indica l.) polymer. Polymers 2021; 13(4):610. https://doi.org/10.3390/polym13040610

Deogade M, Shamrao P, Desai KSR. Efficacy of small group teaching and its comparison with classroom teaching in the subject of dravyaguna. Int J Ayurvedic Med 2017; 8(3):115-133. https://doi.org/10.47552/ijam.v8i3.993

Singh A, Porwal O, Sharma N, Singh A, Kumar S, Sharma PK. Effects of Prebiotics on Git and human health: a review. J Pure Applied Microbiol 2007; 1(1):69-82.

Anwar ET, Gupta N, Porwal O, Sharma A, Malviya R, Singh A, et al., Skin diseases and their treatment strategies in sub-saharan african regions. Infect Disord Drug Targets. 2021; E-pub Ahead of Print. https://doi.org/10.2174/1871526521666210927120334

Sen S, Chakraborty R. Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future. J Tradit Complemen Med 2017; 7(2):234-244. https://doi.org/10.1016/j.jtcme.2016.05.006

Terris MK, Issa MM, Tacker JR. Dietary supplementation with cranberry concentrate tablets may increase the risk of nephrolithiasis. Urology 2001; 57(1):26-29. https://doi.org/10.1016/S0090-4295(00)00884-0

Schmid B, Kötter I, Heide L. Pharmacokinetics of salicin after oral administration of a standardized willow bark extract. Eur J Clin Pharmacol 2001; 57(5):387-391. https://doi.org/10.1007/s002280100325

Sheth S, Tan EC, Tan HH, Tay L. Herb-induced cardio toxicity from accidental aconitine overdose. Singapore Medical Journal, 2015; 56(07):e116-e119. https://doi.org/10.11622/smedj.2015114

Chow E CY, Teo M, Ring JA, Chen JW. Liver failure associated with the use of black cohosh for menopausal symptoms. Medical Journal of Australia, 2008; 188(7):420-422. https://doi.org/10.5694/j.1326-5377.2008.tb01691.x

Gow PJ, Connelly NJ, Crowley P, Angus PW, Hill RL. Fatal fulminant hepatic failure induced by a natural therapy containing kava. Medical J Australia, 2003; 178(9):442-443. https://doi.org/10.5694/j.1326-5377.2003.tb05286.x

Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995; 37(4):364-369.

Published

2021-11-15
Statistics
Abstract Display: 2620
PDF Downloads: 694
PDF Downloads: 508

How to Cite

1.
Porwal O, Kala D. A Review on medicinal plants in dentistry. J. Drug Delivery Ther. [Internet]. 2021 Nov. 15 [cited 2025 Oct. 7];11(6):332-40. Available from: https://jddtonline.info/index.php/jddt/article/view/5128

How to Cite

1.
Porwal O, Kala D. A Review on medicinal plants in dentistry. J. Drug Delivery Ther. [Internet]. 2021 Nov. 15 [cited 2025 Oct. 7];11(6):332-40. Available from: https://jddtonline.info/index.php/jddt/article/view/5128

Most read articles by the same author(s)