A review on medicinal plants as potential sources of natural immunomodulatory action
Abstract
The concept of immunomodulation was proposed by Edward Jenner, while working on polio vaccine in 1796. A brawny, fine-functioning immune system is the keystone of excellent health. Immune replies are the consequence of an effectual interaction among innate (natural and non-specific) and acquired (adaptive and specific) components of the immune system. Inequity or failure of the immune systems is connected with a variety of chronic illness counting allergies, autoimmune diseases, cancers and furthers. Diverse innate and adaptive immune cells that are incorporated in this multifaceted networking organization may symbolize talented targets for expanding immunotherapeutics for treating specific immune illness. An assorted array of natural, synthetic, and recombinant compounds is accessible with both advantages and demerits. A range of phytochemicals have been remote, differentiated and customized for expansion and employ as avoidance or cure of human diseases, but the request of customary or novel medicinal plants for employ as immunomodulators in indulgencing immune diseases is still comparatively limited. At present, there is much-growing interest in the use of medicinal plants as modulators of the complex immune system. Numerous therapeutic consequences of plant extracts have been recommended to be because of their extensive assortment of immunomodulatory effects and persuade on the immune system of the human body. In present review paper, various medicinal plants, their resultant crude or fractionated phyto extracts and the precise phytochemicals remote from them are conversed in terms of their immunomodulatory bioactivities. We also review their possible for future expansion as immunomodulatory or inflammation-regulatory therapeutics or agents.
Keywords: Immunomodulation, Immune system, Phytochemicals, Medicinal plant, Plant extracts
Keywords:
Immunomodulation, Immune system, Phytochemicals, Medicinal plant, Plant extractsDOI
https://doi.org/10.22270/jddt.v11i6.5125References
Sharma P, Kumar P, Sharma R, Gupta G, Chaudhary A. Immunomodulators: Role of medicinal plants in immune system. Natl J Physiol Pharm Pharmacol 2017; 7(6):552-556. https://doi.org/10.5455/njppp.2017.7.0203808032017
Katz L, Baltz RH. Natural product discovery: past, present, and future. J. Ind. Microbiol. Biotechnol 2016; 43(2-3): 155-176. https://doi.org/10.1007/s10295-015-1723-5
David B, Wolfender JL, Dias DA. The pharmaceutical industry and natural products: Historical status and new trends. Phytochem Rev 2015; 14 (2): 299-315. https://doi.org/10.1007/s11101-014-9367-z
Jantan I, Ahmad W, Bukhari SNA. Plant-derived immunomodulators: An insight on their preclinical evaluation and clinical trials. Frontier Plant Sci 2015; 6:655. https://doi.org/10.3389/fpls.2015.00655
Razali FN, Sinniah SK, Hussin H, Zainal Abidin N, Shuib AS. Tumor suppression effect of Solanum nigrum polysaccharide fraction on breast cancer via immunomodulation. Int J Biol Macromol 2016; 92:185-193. https://doi.org/10.1016/j.ijbiomac.2016.06.079
Rasheed HMF, Rasheed F, Qureshi AW, Jabeen Q. Immunostimulant activities of the aqueous methanolic extract of Leptadeniapyrotechnica, a plant from Cholistan desert. J Ethnopharmacol 2016; 186:244-250. https://doi.org/10.1016/j.jep.2016.03.039
Sharma KR, Adhikari A, Jabeen A, Dastagir N, Kalauni SK, Choudhary M, et al., Immunomodulatory studies on triterpenoids from Scopari adulcis Linn. Biochem Pharmacol 2015; 4 (4):182. https://doi.org/10.4172/2167-0501.1000182
Ilyas U, Katare DP, Aeri V, Naseef PP. A review on hepatoprotective and immunomodulatory herbal plants. Pharmacognosy Rev 2016; 10 (19):66-70. https://doi.org/10.4103/0973-7847.176544
Pujol J, Vansteenkiste J, Martino T, Atanackovic D, Reck M, Thomeer M et al., Safety and immunogenicity of MAGE-A3 cancer immunotherapeutic with or without adjuvant chemotherapy in patients with resected stage IB to III MAGE-A3-positive non-small-cell lung cancer. J Thoracic Oncol 2015; 10 (10):1458-1467. https://doi.org/10.1097/JTO.0000000000000653
Tzianabos AO. Polysaccharide immunomodulators as therapeutic structural aspects and biologic function. Clin Microbiol Rev 2000; 13(4):523-533. https://doi.org/10.1128/CMR.13.4.523
Turvey SE, Broide DH. Chapter 2 -innate immunity. J Aller Clin Immunol 2010; 125 (2):S24-S32. https://doi.org/10.1016/j.jaci.2009.07.016
Nicoholson BL. The immune system. Essays in Biochem 2016; 60 (3):275-301. https://doi.org/10.1042/EBC20160017
Kumar D, Arya V, Kaur R, Ali Bhat Z, GuptaVK, Kumar V. A review of immunomodulators in the Indian traditional health care system. J Microbiol, Immunol Infection 2012; 45 (3):165-184. https://doi.org/10.1016/j.jmii.2011.09.030
Billiau A, Matthys P. Modes of action of freund's adjuvants in experimental modes of autoimmune disease. J Leukoc Biol 2001; 70 (6):849-860.
Gertsch J, Viveros-Paredes JM, Taylor P. Plant immunestimulants-scientific paradigm or myth. J Ethnopharmacol 2011; 136 (3):385-391. https://doi.org/10.1016/j.jep.2010.06.044
George A, Shah PA, Shrivastav PS. Guar gum: Versatile natural polymer for drug delivery applications. Eur Polym J 2018; 112:722-735. https://doi.org/10.1016/j.eurpolymj.2018.10.042
Narayanaswamy V. Origin and development of ayurveda. Anc Sci life 1981; 1(1):1-7.
Vogel HG. Drug Discovery and Evaluations. 2nd ed. New-York: Springer-Verlang; 2002. pp. 775-90. https://doi.org/10.1007/3-540-29837-1_10
Mohan MR, Rao GBS, Narender B, Kumar CA, Rao PV, Bakshi V. Indian medicinal plants used as immunomodulatory agents: A review. Int J Green Pharm 2019; 13 (4):312-318.
Oberlies NH, Kroll DJ. Camptothecin and taxol: historic achievements in natural products research. J Nat Prod 2004; 67:129-135. https://doi.org/10.1021/np030498t
Jantan I, Ahmad W, Bukhari SNA. Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci 2015; 6: 655. https://doi.org/10.3389/fpls.2015.00655
Singh N, Tailang M, Mehta SC. A review on herbal plants as immunomodulators. Int J Pharm Sci Res 2016; 7(9):3602-3610.
Nagarathna PKM, Reena K, Reddy S, Wesley J. Review on immunomodulation and immunomodulatory activity of some herbal plants. Int J Pharm Sci Rev Res 2013; 22(1):223-230.
Patel R, Gautam P, Tabish M, Kumar S. Herbal plants used for immunomodulatory action: a review. Int J Res Pharm Sci 2012; 2(3):14-26. https://doi.org/10.7439/ijpp.v2i2.388
Ismail S, Asad M. Immunomodulatory activity of Acacia catechu. Indian J Physiol Pharmacol 2009; 53:25-33.
Jeong SC, Jeong YT, Yang BK, Song CH. Chemical characteristics and immuno-stimulating properties of biopolymers extracted from Acanthopanaxsessiliflorus. J Biochem Mol Biol 2006; 39:84-90. https://doi.org/10.5483/BMBRep.2006.39.1.084
Noori S, Naderi GA, Hassan ZM, Habibi Z, Bathaie SZ, Hashemi SM, et al., Immunosuppressive activity of a molecule isolated from Artemisia annuaon DTH responses compared with cyclosporin A. Int Immunopharmacol 2004;4:1301-6. https://doi.org/10.1016/j.intimp.2004.05.003
Sharififar F, Pournourmohammadi S, Arabnejad M. Immunomodulatory activity of aqueous extract of Achillea wilhelmsii C. Koch in mice. Indian J Exp Biol 2009; 47:668-71.
Mukesh SS, Patil MB, Sharma S, Bhat V. Aloe vera: Plant of immortality. Int J Pharm Sci Res 2010; 1:7-10.
Porwal O, Singh SK, Patel DK, Gupta S, Tripathi R, Katekhaye S. Cultivation, Collection and Processing of Medicinal Plants. Bioactive Phytochemicals: Drug Discovery to Product Development. 2020:14-30. https://doi.org/10.2174/9789811464485120010005
Ramanunny AK, Wadhwa S, Gulati M, Gupta S, Porwal O, Jha NK, et al., Development and validation of RP-HPLC method for 1΄-Acetoxychavicol acetate (ACA) and its application in optimizing the yield of ACA during its isolation from Alpiniagalanga extract as well as its quantification in nanoemulsion. South African J Botany 2021 https://doi.org/10.1016/j.sajb.2021.10.012
Clement F, Pramod SN, Venkatesh YP. Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins. Int Immunopharmacol2010; 10:316-24. https://doi.org/10.1016/j.intimp.2009.12.002
Chakraborthy GS. Evaluation of immunomodulatory activity of Aesculus indica. Int J Pharm Tech Res 2009; 1:132-4.
Naik SR, Hule A. Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata. Planta Med 2009; 75:785-91. https://doi.org/10.1055/s-0029-1185398
Bopana N, Saxena S. Asparagus racemosus ethnopharmacological evaluation and conservation needs. J Ethnopharmacol 2007; 110:1-15. https://doi.org/10.1016/j.jep.2007.01.001
Sood A, Kumar B, Singh SK, Prashar P, Gautam A, Gulati M, et al., Flavonoids as potential therapeutic agents for the management of diabetic neuropathy. Curr Pharm Design. 2020; 26(42):5468-5487. https://doi.org/10.2174/1381612826666200826164322
Singh S, Singh SK, Kumar B, Kaur B, Khursheed R, Gulati M, et al., Effect of co-administration of herbal extracts with copper nanoparticles: a novel two-pronged approach in treating type 2 diabetes. Recent Innov Chem Eng.2020; 13(5):366-378. https://doi.org/10.2174/2405520413999200719140819
Banerjee M, Khursheed R, Yadav AK, Singh SK, Gulati M, Pandey DK, et al., A systematic review on synthetic drugs and phytopharmaceuticals used to manage diabetes. Curr Diabetes Rev 2020; 16(4):340-356. https://doi.org/10.2174/1573399815666190822165141
Gokhale AB, Damre AS, Saraf MN. Investigations into the immunomodulatory activity of Argyreia speciosa. J Ethnopharmacol 2003; 84:109-14. https://doi.org/10.1016/S0378-8741(02)00168-X
Dashputre NL, Naikwade NS. Immunomodulatory activity of Abutilon indicum Linn. On albino mice. Int J Pharm Sci Res 2010; 1:178-84.
Tilwari A, Shukla NP, Pathirissery UD. Immunomodulatory activity of the aqueous extract of seeds of Abrus precatorius Linn (Jequirity) in mice. Iran J Immunol2011; 8:96-103.
Vinothapooshan G, Sundar K. Immunomodulatory activity of various extracts of Adhatoda vasica Linn. In experimental rats. Afr J Pharm Pharmacol 2011; 5:306-10. https://doi.org/10.5897/AJPP10.126
Shah AS, Gunjal MA, Juvekar AR. Immunomostimulatory activity of aqueous extract of Azadirachtaindicaflowers on specific and non specific immune response. J Nat Rem 2009; 9:35-42.
Ghaisas MM, Saikh SA, Deshpande AD. Evaluation of immunomodulatory activity of ethanolic extract of stem bark of Bauhinia variegata Linn. Int J Green Pharm 2009; 3:70-4. https://doi.org/10.4103/0973-8258.49379
Mungantiwar AA, Nair AM, Shinde UA, Dikshit VJ, Saraf MN, Thakur VS, et al., Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction. J Ethnopharmacol1999; 65:125-31. https://doi.org/10.1016/S0378-8741(98)00153-6
Korek J, Shete RV, Kabra MP, Rachhadiya RM, Attal AR. Immunomodulatory activity of Balanite roxburghii. J Pharm Res Health Care 2014; 3:63-7.
Hussain FHS, Amin HIM, Patel DK, Porwal O. An overview of the therapeutic potential of Iris persica. Curr Tradit Med 2021; 7(2):152-160. https://doi.org/10.2174/2215083806666200117111320
Porwal O, Gupta S, Nanjan MJ, Singh A. Classical taxonomy studies of medicinally important Ipomoea leari. Ancient Sci Life 2015; 35(1):34. https://doi.org/10.4103/0257-7941.165628
Porwal O, Nanjan MJ, Chandrasekar MJN, Srinivasan R, Gupta S. Anticancer potential of solanum jasminoides Int J Pharm Sci Res 2014;5(9):3768-3774.
Chandrasekar MJN, Srinivasan R, Porwal O, Nanjan MJ. In-Vitro antioxidant activity of solanum jasminoides paxt extracts. J Nat Remed 2012; 12(2):115-118.
Thakur M, Bhargava S, Dixit VK. Immunomodulatory activity of Chlorophytum borivilianum Sant. F. Evid Based Complement Alternat Med 2007; 4:419-23. https://doi.org/10.1093/ecam/nel094
Gaur K, Kori ML, Nema RK. Comparative screening of immunomodulatory activity of hydro-alcoholic extract of Hibiscus rosa-sinensis Linn. and ethanolic extract of Cleome gynandra Linn. Glob J Pharmacol 2009; 3:85-9.
Jiménez-Medina E, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F, et al., A new extract of the plant Calendula officinalis produces a dual in vitro effect: Cytotoxic anti-tumor activity and lymphocyte activation. BMC Cancer 2006; 6:119. https://doi.org/10.1186/1471-2407-6-119
Mali RJ, Hatapakki BC. An in vitro study of effect of Centella asiatica on phagocytosis by human neutrophils. Int J Pharm Sci Nanotechnol 2008; 1:297-302. https://doi.org/10.37285/ijpsn.2008.1.3.13
Anarthe SJ, Spoorthisudha P, Swetha M, Raju MG. In vitro and in vivo screening of Clitoria ternatea (Linn.) for immunomodulatory activity. Int J Chem Tech Res 2017; 10:116-25.
Antony S, Kuttan R, Kuttan G. Immunomodulatory activity of curcumin. Immunol Invest 1999; 28:291-303. https://doi.org/10.3109/08820139909062263
Vishwas S, Gulati M, Kapoor B, Gupta S, Singh SK, Awasthi A, et al., Expanding the arsenal against Huntington's disease-Herbal drugs and their nanoformulations. Curr Neuropharmacol 2021; 19(7):957-989. https://doi.org/10.2174/1570159X18666201109090824
Malviya R, Sundram S, Fuloria S, Subramaniyan V, Sathasivam KV, Azad AK, et al., Evaluation and characterization of tamarind gum polysaccharide: The biopolymer. Polymers 2021; 13(18):3023. https://doi.org/10.3390/polym13183023
Porwal O, Malviya R, Ameen MSM, Anwar ET, Sharma A. A review on effect of various parameters on the rheological behaviour, thermal properties and viscosity of potato starch. Curr Materials Sci 2021; E-pub Ahead of Print. https://doi.org/10.2174/2666145414666210521214130
Malviya R, Raj S, Fuloria S, Subramaniyan V, Sathasivam K, Kumari U, et al., Evaluation of antitumor efficacy of chitosan-tamarind gum polysaccharide polyelectrolyte complex stabilized nanoparticles of simvastatin. Int J Nanomed 2021; 16:2533-2553. https://doi.org/10.2147/IJN.S300991
Gharagozloo M, Ghaderi A. Immunomodulatory effect of concentrated lime juice extract on activated human mononuclear cells. J Ethnopharmacol2001; 77:85-90. https://doi.org/10.1016/S0378-8741(01)00269-0
Surendra SA, Saurabh CK, Gokul ST. Studies on immunomodulatory Activity of Capparis zeylanica leaf extracts. Int J Pharm Sci Nanotechnol2010; 3:887-92. https://doi.org/10.37285/ijpsn.2010.3.1.14
Bafna A, Mishra S. Antioxidant and immunomodulatory activity of the alkaloidal fraction of Cissampelos pareira Linn. Sci Pharm 2010; 78:21-31. https://doi.org/10.3797/scipharm.0904-16
Shukla S, Mehta A, John J, Mehta P, Vyas SP, Shukla S, et al., Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds. J Ethnopharmacol2009; 125:252-6. https://doi.org/10.1016/j.jep.2009.07.002
Kaur G, Singh SK, Kumar R, Kumar B, Kumari Y, Gulati M, et al., Development of modified apple polysaccharide capped silver nanoparticles loaded with mesalamine for effective treatment of ulcerative colitis. J Drug Del Sci Tech 2020; 60: 1-10. https://doi.org/10.1016/j.jddst.2020.101980
Som S, Singh SK, Khatik GL, Kapoor B, Gulati M, Kuppusamy G, et al., Quality by design-based crystallization of curcumin using liquid antisolvent precipitation: micromeritic, biopharmaceutical, and stability aspects. Assay Drug Develop Techn 2020; 18(1):11-33. https://doi.org/10.1089/adt.2018.913
Singh A, Porwal O, Sharma N, Singh A, Kumar S, Sharma PK. Effects of prebiotics on git and human health: a review. J Pure Appl Microbiol 2007; 1(1):69-82.
Anwar ET, Gupta N, Porwal O, Sharma A, Malviya R, Singh A, et al., Skin diseases and their treatment strategies in sub-saharan african regions. Infect Disord Drug Targets. 2021. E-pub Ahead of Print. https://doi.org/10.2174/1871526521666210927120334
Ameen MS, Malviya R, Porwal O, Anwar ET, Pant S, Sharma A. Novel Strategies and Model Studies for Colon Targeted Drug Delivery. Drug Delivery Letters. 2021; 11(2):156-63. https://doi.org/10.2174/2210303111666210118141406
Jayathirtha MG, Mishra SH. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 2004; 11:361-5. https://doi.org/10.1078/0944711041495236
Patil SB, Naikwade NS, Magdum CS. Review on phytochemistry and pharmacological aspects of Euphorbia hirta Linn. J Pharm Res Health Care 2009; 1:113-33.
Vikas VP, Shandavi CB, Vijay RP. Studies on immunomodulatory activity of Ficuscarica. Int J Pharm PharmSci 2010; 2:97-9.
Gabhe SY, Tatke PA, Khan TA. Evaluation of the immunomodulatory activity of the methanol extract of Ficusbenghalensisroots in rats. Indian J Pharmacol2006; 38:271-5. https://doi.org/10.4103/0253-7613.27024
Habijanic J, Berovic M, Wraber B, Hodzar D, Boh B. Immunostimulatory effects of fungal polysaccharides from Ganoderma lucidum sub merged biomass cultivation. Food TechnolBiotechnol 2001; 39:327-31.
Sudhakar K, Fuloria S, Subramaniyan V, Sathasivam KV, Azad AK, Swain SS, et al., Ultraflexible liposome nanocargo as a dermal and transdermal drug delivery system. Nanomaterials 2021; 11(10):2557. https://doi.org/10.3390/nano11102557
Khan TA, Azad AK, Fuloria S, Nawaz A, Subramaniyan V, Akhlaq M, et al., Chitosan-coated 5-fluorouracil incorporated emulsions as transdermal drug delivery matrices. Polymers 2021;13(19):3345. https://doi.org/10.3390/polym13193345
Malviya R, Jha S, Fuloria NK, Subramaniyan V, Chakravarthi S, Sathasivam K, et al., Determination of temperature-dependent coefficients of viscosity and surface tension of tamarind seeds (tamarindus indica ) polymer. Polymers 2021; 13(4):610. https://doi.org/10.3390/polym13040610
Jha R, Singh A, Sharma PK, Porwal O, Fuloria NK. Graphene-based nanomaterial system: A boon in the era of smart nanocarriers. J Pharm Investig 2021; 51:245-280. https://doi.org/10.1007/s40005-021-00513-3
Ghosh D, Singh SK, Khursheed R, Pandey NK, Kumar B, Kumar R, et al., Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid. Drug Develop Indus Pharm 2020; 46(4):597-605. https://doi.org/10.1080/03639045.2020.1742143
Kumari Y, Kaur G, Kumar R, Singh SK, Gulati M, Khursheed R, et al., Gold nanoparticles: New routes across old boundaries. Adv Colloid interface Sci 2019; 274:102037. https://doi.org/10.1016/j.cis.2019.102037
Malik JK, Manvi FV, Nanjwade BK, Alagawadi KR, Sinsh S. Immunomodulatory activity of Gymnema sylvestre R. Br. leaves on in vitro human neutrophils. J Pharm Res 2009; 2:1284-6. https://doi.org/10.4103/0973-8258.41184
Sahu MS, Sahu RA, Verma A. Immunomodulatory activity of alcoholic extract of Habenaria intermedia in mice. Int J Pharm Pharm Sci2013; 5:406-9.
Jain V, Bhagwat D, Jat RC, Bhardwaj S. The immunomodulation potential of Hyptis suaveolens. Int J Pharm Res Dev 2005; 1:1-6.
Gan L, Zhang SH, Liu Q, Xu HB. A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells. Eur J Pharmacol 2003; 471:217-22. https://doi.org/10.1016/S0014-2999(03)01827-2
Gupta A, Gautam MK, Singh RK, Kumar MV, Rao CV, Goel RK, et al., Immunomodulatory effect of Moringa oleifera Lam. Extract on cyclophosphamide induced toxicity in mice. Indian J Exp Biol2010; 48:1157-60.
Bharani SE, Asad M, Dhamanigi SS, Chandrakala GK. Immunomodulatory activity of methanolic extract of Morus alba Linn. (mulberry) leaves. Pak J Pharm Sci 2010; 23:63-8.
Shah AS, Wakade AS, Juvekar AR. Immunomodulatory activity of methanolic extract of Murraya koenigii (L) spreng. Leaves. Indian J Exp Biol2008; 46:505-9.
Makare N, Bodhankar S, Rangari V. Immunomodulatory activity of alcoholic extract of Mangifera indica L. In mice. J Ethnopharmacol 2001; 78:133-7. https://doi.org/10.1016/S0378-8741(01)00326-9
Kannan M, Ranjit SA, Ajith KT, Jegatheswari P, Subburayalu S. Studies on immuno-bioactivities of Nyctanthes arbor-tristis(Oleaceae). Afr J Microbiol Res 2007; 1:88-91. https://doi.org/10.1007/978-0-387-70638-2_1074
Caroline JR, Rama V, Rameshkumar G. Immunomodulatory activity of aqueous extract of Ocimum sanctum in rat. Int J Pharm Biomed Res 2011; 233-8.
Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurrooa leaf extract. J Ethnopharmacol 1994; 41:185-92. https://doi.org/10.1016/0378-8741(94)90031-0
Sunila ES, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. And piperine. J Ethnopharmacol 2004; 90:339-46. https://doi.org/10.1016/j.jep.2003.10.016
Kim MH, Byon YY, Ko EJ, Song JY, Yun YS, Shin T, et al. Immunomodulatory activity of ginsan, a polysaccharide of panax ginseng, on dendritic cells. Korean J Physiol Pharmacol 2009; 13:169-73. https://doi.org/10.4196/kjpp.2009.13.3.169
Meeran SM, Katiyar S, Elmets CA, Katiyar SK. Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice. Mol Cancer Ther2006; 5:1660-8. https://doi.org/10.1158/1535-7163.MCT-06-0095
Im SA, Kim K, Lee CK. Immunomodulatory activity of polysaccharides isolated from Salicornia herbacea. IntImmunopharmacol 2006; 6:1451-8. https://doi.org/10.1016/j.intimp.2006.04.011
Mastan SK, Saraseeruha A, Gourishankar V. Immunomodulatory activity of methanolic extract of Syzygium cumini seeds. Pharmacologyonline 2008; 3:895-903.
Gohla SH, Zeman RA, Bogel M, Jurkiewicz E, Schrum S, Haubeck HD, et al.. Modification of the in vitro replication of the human immunodeficiency virus HIV-1 TPSg, a polysaccharide fraction isolated from the Cupressaceae Thuja occidentalis L arborvitae. Haematol Blood Transfus1992; 35:140-9. https://doi.org/10.1007/978-3-642-76829-3_24
Halder S, Bharal N, Mediratta PK, Kaur I, Sharma KK. Anti-inflammatory, immunomodulatory and antinociceptive activity of Terminalia arjuna Roxb bark powder in mice and rats. Indian J ExpBiol 2009; 47:577-83.
Sinha K, Mishra NP, Singh J, Kanjua SPS. Tinospora cordifolia, a reservoir plant for therapeutic applications: A review. Indian J TraditKnowl 2004; 3:257-70.
Samir P, David B, Otilia JF, Patel MM, Shah KK. Scrutinizing the role of aqueous extract of Trapa bispinosaas an immunomodulator in experimental animals. Int J Res Pharm Sci 2010; 1:13-9.
Agarwal S, Khadase S, Talele G. Bioactive immunomodulatory fraction from Tridaxprocumbens. Asian J Biol Sci 2010; 3:120-7. https://doi.org/10.3923/ajbs.2010.120.127
Rinku M, Prasanth VV, Parthasarathy G. Immunomodulatory activity of the methanolic extract of Urenalobata Linn. Int J Pharmacol 2008; 7:14. https://doi.org/10.5580/ba4
Davis L, Kuttan G. Immunomodulatory activity of Withania somnifera. J Ethnopharmacol 2000; 71:193-200. https://doi.org/10.1016/S0378-8741(99)00206-8
Devasagayam TPA, Sainis KB. Immune system and antioxidants, especially those derived from indian medicinal plants. Indian J Exp Biol 2002; 40:639-655
Gulati K, Ray A, Debnath PK. Immunomodulatory Indian Medicinal Plants. J Natural Rem 2002; 2(2):121-131
Sagarwat H, Md Khan Y. Immunomodulatory plants: A Phytoparmacological review. Pharmacog Rev 2007; 1(2):248-260
Mukherjee PK, Nema NK, Bhadra S. Immunomodulatory leads from medicinal plants. Indian J Knowledge. 2014; 13(2):235-256 https://doi.org/10.1016/B978-0-12-397153-1.00022-6
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