Hydrodynamically Balanced System: A Review
The most suitable drug delivery route is oral delivery due to its easily administration, patient adherence/ patient capacitance etc. Several approaches have been made for maximizing the G.R.T such as high-density system, floating system, swelling & expanding system and mucoadhesive & bio adhesive system etc. the main motive of reviewing the article is to focus on the mechanism of HBS system, classification with new system such as raft forming system and hollow microsphere, its application, marketed preparation and evaluation study. The procedure of gastric emptying is a complex and may leads to uncertainty for in vivo performance of the DDS. To prevent this type of complex formation and uncertainty, hard work has been done to expand the retention time of DDS for half of the day. The FDDS are beneficial in such process.
Keywords: HBS system, GRDDS, gastric residence time (G.R.T), raft forming systems, floating formulations, evaluation study.
2) Desai S, Bolton S. A floating controlled release drug delivery system: in vitro-in vivo evaluation. Pharm. Research 1993; 10:1321-1325.
3) Reddy L.H, Murthy R.H. Floating dosage systems in drug delivery, Crit.Rev. Ther. Drug Carr. Syst. 2002; 19(6):553-585.
4) Yvonne P, Thomas R. Sustained-release delivery systems, Indian edition. Gastroretentive drug delivery systems. Replika Press; 2010. p. 90-91.
5) Yvonne P, Thomas R. Sustained-release delivery systems, Indian edition. Gastroretentive drug delivery systems. Replika Press; 2010. p. 92.
6) Thanoo B.C, Sunny M.C. and Jayakrishnan A. Oral sustained-release drug delivery systems using polycarbonate microspheres capable of floating on the gastric fluid. J. Pharm. Pharmacol. 1993; 45:21-24.
7) Khairnar Vinit S, Patil S.T, Pawar S.P,Effervescent Floating drug delivery system: a review, International Journal of Pharma and Chemical research 2017; 3:260-266.
8) Marinaganti RK, Bonthu S, Nagakanyaka DP, Sheikh M. A comprehensive review on gastroretentive drug delivery system 2013; 3(2):149-164.
9) Timmermans J, Moes A. How well floating dosage do forms float? Int J pharm 1990; 62:207-16.
10) Kulkarni DP and Saboo SS., Polymers used in floating drug delivery system: A review. European Journal of Pharmaceutical and Medical Research 2017; 4(8):611- 616.
11) El-Kamel A.H, Sokar M.S, Algamal S.S, Naggar V.F. Preparation and evaluation of ketoprofen floating oral drug delivery system. Int. J. Pharm. 2001; 220:13- 21.
12) Kawashima Y, Niwa T, Takeuchi H, Hino T, ItoY. Preparation of multiple unit hollow microspheres (microballoons) with acrylic resins containing tranilast and their drug release characteristics (in vivo). J. Cont. Rel. 1991; 16:279-290.
13) Gu T.H. et al. Pharmacokinetics and pharmacodynamics of diltiazem floating tablets. Chung Kao Yao Li Hsuesh Pao. 1992; 13:527-531.
14) Chanchal, Kumar S, Kakar S., A Review on Floating Tablet. Indian Journal of Pharmaceutical and Biological Research 2018; 6(1): 22-29.
15) Rouge N, Cole E.T, Doelker E, Buri P. Buoyancy and drug release patterns of floating mini tablets containing piretanide and atenolol as model drugs. Pharm. Dev. Technol. 1998; 3:73-84.
16) Patel GM. Floating drug delivery system: An innovative approach to prolong gastric retention. www.pharmainfo.net, 2007.
17) Gholap SB, Banarjee SK, Gaikwad DD, Jadhav SL, Thorat R M, Hollow microspheres: A Review, International Journal of pharma science research 2010; 1(1):74-79.
18) Cheuh H.R, Zia H, Rhodes C.T. Optimization of Sotalol floating and bioadhesive extended-release tablet formulation. Drug Dev. Ind. Pharm.1995; 21:1725-1747.
19) Gustafson J.H, Weissman L, Weinfeld R.T. et al. Clinical bioavailability evaluation of a controlled release formulation of diazepam. J. Pharmacokinet. Biopharm. 1981; 9:679-691.
20) Hardenia SS, Jain A, Patel R, kaushal A, Floating drug delivery systems: A review, Asian Journal of Pharmacy and Life Science, 2011; 1(3):284-293.
21) Moursy NM, Afifi NN, Ghorab DM, El-Saharty Y. Formulation and evaluation of sustained release floating capsules of Nicardipine hydrochloride. Pharmazie. 2003; 58:38-43.
22) Hegyesi, D. Study of the Widely Used Ethylcellulose Polymer as Film Forming and Matrix Former Ph. D. Thesis Diána Hegyesi Pharmacist, 2016.
23) Whitehead L, Collet JH, Fell JT, Sharma HL, Smith AM. Floating dosage forms: an in vivo study demonstrating prolonged gastric retention. J Control Release 1998; 55:3‐12.
24) Menon A, Ritschel WA, Sakr A. Development and evaluation of a monolithic floating dosage form for furosemide. J Pharm Sci. 1994; 83:239-245.
25) Oth M, Franz M, Timmermans J, Moes A. The bilayer floating capsule: a stomach directed drug delivery system for misoprostal. Pharm Res. 1992; 9:298-302.
26) Kumar, G. Natural Polymers in the Development of Floating Drug Delivery Systems: A Review. Int. J. Pharm. Life Sci. 2013; 2(4):165–178.
27) Jain SK, Jain NK, Agrawal GP. Gastroretentive floating drug delivery: An overview. Drug Deliv Technol 2005; 5:7-15.
28) Jain AK, Hatila U, A review on floating drug delivery system, International Journal of Pharmaceutical Studies and Research 2011; 2(3):1-6.
29) Vidyadhara S, Rao PR, Prasad JA, Development and In-Vitro Kinetic of propanolol hydrochloride-controlled release matrix tablets, The Indian Pharmacist 2006; 66-70.
30) Nandigoti J, Shayeda, Floating drug delivery system, International Journal of Pharmaceutical Sciences and Nanotechnology 2009;2(3):595-604.
31) Reddy VS, Badarinath AV, Prakash KG., Formulation and evaluation of floating tablets of ciprofloxacin hydrochloride. Asian Journal of Pharmaceutics 2018; 12(2):106-113.
32) Sharma N, Agarwal D, Gupta MK, Khinchi MP, A comprehensive review on floating drug delivery system, International Journal of Research in Pharmaceutical and Biomedical Sciences 2011; 2(2):428-441.
33) Patil JM, Hirlekar RM, Gide PS, Kadam VJ, Trends in floating drug delivery system, Journal of Scientific and Industrial Research 2006; 65:11-21.
34) Mayavanshi AV, Gajjar SS. Floating drug delivery systems to increase gastric retention of drugs: A Review. J Pharm Tech 2008; 1(14):345‐348.
35) Haranath C, Reddy JR, Devanna N., Formulation and evaluation of non-effervescent floating tablets of cimetidine employing ozokerite wax. International journal of research in pharmacy and chemistry 2017; 7(2):171- 180.
36) Nagamani V, Jhansi C., Formulation and Evaluation of Floating Tablets Using Nimesulide as a Model Drug. International Research Journal of Engineering and Technology 2017; 4:1245-1250.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).