A Review on Solubility Enhancement by Solid Dispersion Method
The issues of solubility for the targeted drug delivery of the new drug affects, the delivery many existing drug. The minimum 40% of the novel drug from the pharmaceutical industries are showing poor ability of solubilization in water. Hence to increase the solubility of such drug in waters and to increase their bioavailabilities are the major challenges to the scientists. So to overcome such problems and increase dissolution, development of solid dispersion with carriers having good water solubility is beneficiary. Hence solid dispersion methods are found to be an effective method to develop the solubility factor of the drug which showing poor solubility in water. The review highlights the various aspect of solid dispersion type, rational, advantages, limitation and manufacturing processes for the limited commercialization of solid dispersion.
Keywords: Solid dispersions, hydrophilic, carrier, solubility, polymer, bioavailability.
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