A Review on Solubility Enhancement by Solid Dispersion Method

  • Laxmikant B. Dhande M. Pharm. Student, Department of pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India
  • Madhuri T. Deshmukh Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India
  • Abhijit N. Khopade Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India
  • Rajkumar V. Shete Principal, Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India
  • Vaibhavi V. Kunjir Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India

Abstract

The issues of solubility for the targeted drug delivery of the new drug affects, the delivery many existing drug. The minimum 40% of the novel drug from the pharmaceutical industries are showing poor ability of solubilization in water. Hence to increase the solubility of such drug in waters and to increase their bioavailabilities are the major challenges to the scientists. So to overcome such problems and increase dissolution, development of solid dispersion with carriers having good water solubility is beneficiary. Hence solid dispersion methods are found to be an effective method to develop the solubility factor of the drug which showing poor solubility in water. The review highlights the various aspect of solid dispersion type, rational, advantages, limitation and manufacturing processes for the limited commercialization of solid dispersion.


Keywords: Solid dispersions, hydrophilic, carrier, solubility, polymer, bioavailability.

Keywords: Solid dispersions, hydrophilic, carrier, solubility, polymer, bioavailability

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Author Biographies

Laxmikant B. Dhande, M. Pharm. Student, Department of pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India

M. Pharm. Student, Department of pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-   412206   Pune, Maharashtra, India

Madhuri T. Deshmukh, Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India

Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-   412206   Pune, Maharashtra, India

Abhijit N. Khopade, Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India

Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-   412206   Pune, Maharashtra, India

Rajkumar V. Shete, Principal, Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India

Principal, Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-   412206   Pune, Maharashtra, India

Vaibhavi V. Kunjir, Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- 412206 Pune, Maharashtra, India

Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-   412206   Pune, Maharashtra, India

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Dhande LB, Deshmukh MT, Khopade AN, Shete RV, Kunjir VV. A Review on Solubility Enhancement by Solid Dispersion Method. JDDT [Internet]. 15Jan.2021 [cited 28Sep.2021];11(1):182-7. Available from: https://jddtonline.info/index.php/jddt/article/view/4489