Pharmacological Modeling and Study for Antidiabetic Activity of Praecitrullus fistulosus Leaves Extracts
Phytochemical and pharmacological investigations of leaves of Praecitrullus fistulosus for the antidiabetic activity have been done in our research work encompassed in depth and systematic screening of plant leaves and further extraction, characterization and bioevaluation. The research was envisaged for antidiabetic activity of different extracts procured by successive extraction methods and to find out or isolate the most possible active compounds from the active extracts showing the best activity. The antidiabetic activity of all extracts has been evaluated by STZ induced diabetes. The isolated compounds have been evaluated by in-vitro and in-vivo models. The alcohol soluble extractives values were found to be higher than water soluble extractive value. Alcohol being a moderately non polar solvent, able to extract polar and non-polar components yields higher extractive value. The ethanol extract shows significant enhancement in glucose tolerance in glucose fed hyperglycemic normal rats and produced a marked decrease in blood glucose levels at 200 mg/kg and 400 mg/kg body weight in streptozotocin-diabetic rats after 21 days treatment.
Keywords: Praecitrullus fistulosus, Streptozotocin and Glibenclamide, diabetes, Pharmacological Evaluation
2. Ahmed M F, Kazim S F, Ghori S S, Mehjabeen S S, Ahmed S R, Ali S M, Ibrahim M. Antidiabetic activity of Vinca rosea extracts in alloxan-induced diabetic rats. International Journal of Endocrinology 2010; 1- 6
3. Rajaram K. Antioxidant and antidiabetic activity of Tectona Grandis Linn in alloxan induced albino rats. Asian Journal of Pharmaceutical and Clinical Research 2013; (6)3:174-177
4. Patel K, Srinivasan K. Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycemic agents. Journal Nahrung Food 1997; 41:68–74.
5. He C N, Wang C L, Guo S X. Study on chemical constituents in herbs of Anoectochilus roxburghii. China Journal of Chinese Materia Medica 2005; 30:761–776
6. Shah K., Garg G., Jhade D., Pandey H., Ficus racemosa linn: Its potentials food security and rural medicinal management, J. Pharm. Sci. & Res. 2016; 8(5):317-322
7. Verspohl E J. Recommended testing in diabetes research. Planta Medica 2002; 68:581– 590
8. Khalid G, Bashir AG, Seema A, Khan M, Showkat AD, Mohammad YD and Mudasir AT: Antidiabetic activity of Artemisia amygdalina Decne in streptozotocin induced diabetic rats. BioMed Research International 2014; 1-10
9. Gautam S, Singh P and Shivhare Y: Praecitrullus fistulosus A Miraculous Plant. Asian Journal of Pharmacy and Technology 2011; 1(1):9-12
10. Gautam S, Singh P and Shivhare Y: Anthelmintic potential of Praecitrullus fistulosus (fruits). International Journal of Drug Discovery and Herbal Research 2011; 1(2):104-105
11. Gautam S and Shivhare Y: Phytochemical screening and antioxidant potential of Praecitrullus fistulosus. Journal of Advanced Pharmacy Education & Research 2011; 1(5):238-242
12. Karandikar A, Prasath G S and Subramanian S: Evaluation of antidiabetic and antioxidant activity of Praecitrullus fistulosus in STZ induced diabetic rats. Research Journal of Pharmacy and Technology 2014; 1(5):238-242
13. OECD Guideline for testing of chemicals Acute Oral Toxicity – Acute Toxic Class Method 2001.
14. Chattopadhyay R R. A comparative evaluation of some blood sugar lowering agents of plant origin. Journal of Ethnopharmacology 1999; 67:367-372
15. Jaiswal J, Bhardwaj H, Srivastava S, Gautam H, Sharma S, Rao C V. Anti-diabetic activity of methanolic extract of calotropis gigantea seeds on STZ induced diabetic rats. International Journal of Pharmacy and Pharmaceutical Sciences 2014; 6(1):254-257
16. Edwin E. Anti-hyperglycemic activity of Passiflora mollissima bailey. Indian Journal of Pharmaceutical Sciences 2007; 69(4):570-571
17. Chattopadhyay S. Animals in experimental diabetes mellitus. Indian journal of experimental biology 1997; 35:1141–1145.
18. Kushwaha S, Shah S.K, Patel N., Tyagi C.K., Effects of hydroalcoholic extract of Allium sativum on STZ induce hyperglycemia, The Pharma Innovation Journal 2016; 5(8):106-110.
19. Yasodamma S, Shanthi S K, Alekhya C. anti-diabetic activity of Sebastiania chameleon Muell leaf extracts in alloxan induced diabetic albino rats. International Journal of Pharmacy and Pharmaceutical Sciences 2013; 5(3):577-583.
20. Verma V K, Sarwa K K, Zaman K. Anti-hyperglyceimic properties of Swertia chirayita and Andrographis paniculata plant extracts in streptozotocin induced diabetic rats. International Journal of Pharmacy and Pharmaceutical Sciences 2013; 5(3):305-31.
21. CK Tyagi, Pawan Porwal, Neeraj Mishra, Amit Sharma, A Chandekar, R Punekar, VT Punniyakoyi, Ajay Kumar, Durgadas Anghore, Antidiabetic Activity of the Methanolic Extracts of Thuja occidentalis Twings in Alloxan-induced Rats, Current Traditional Medicine 2019; 5(2):1-10.
22. Rahar S, Swami G, Nagpal N, Nagpal M A, Singh G S. Preparation, characterization, and biological properties of β- glucans. Journal of Advanced Pharmaceutical Technology & Research 2011; (2):94–103.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).