Evaluation of anti-ulcer activity of the leaf extract of Solanum pubescens willd. (Solanaceae) in Wistar albino Rats

  • C K Tyagi Sri Satya Sai University of Technology and Medical Sciences
  • Satendra Kumar Saha College of Pharmacy Sri Satya Sai University of Technology and Medical Sciences, Sehore, MP, India
  • Sunil Kumar Shah TIT College of Pharmacy, Bhopal, MP, India


The present study showed that the methonolic extract of Solanum pubescens willd leaves possess Anti- ulcer in animal model. The anti-ulcer activity was evaluated against Pylorus ligated ulcers. Gastric ulcer disease is an imbalance between mucosal defense factors (bicarbonate, mucin, prostaglandin, nitric oxide, and other peptides and growth factors) and injurious factors (acid and pepsin). Oral administration of methanol extract of solanum pubescens willd at doses of 200 and 400mg/kg exhibited dose dependent inhibition percentage of 36.28% and 52.3% (p<0.001) respectively compared to the ulcer control, proving the anti-ulcer activity. The standard drug omeprazole (20mg/kg) exhibited percentage inhibition of 70% when compared with ulcer control. Extract treated and ulcer control group was compared with normal control group. Result showed a significant decrease in the ulcer development in the animal models (pylorus ligated model) used in the study. In pylorusligation, both the doses showed significantant ulcer activity by reduction in ulcer index, gastric volume, free acidity, total acidity as compared to the control group. The intensity of heamorrhage and lesions was significantly reduced upon pretreatment with the extract, revealing the protective effect of MESP. Flavonoids and tannins are the major constituents that are present in the leaves of Solanum pubescens willd which may be responsible for its Ulcer- protective and Anti- ulcer activity.

Keywords: Peptic ulcer, Solanum pubescens, Wistar rats, Acute Oral toxicity, ANOVA

Keywords: Peptic ulcer, Solanum pubescens, Wistar rats, Acute Oral toxicity, ANOVA


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Author Biographies

C K Tyagi, Sri Satya Sai University of Technology and Medical Sciences

College of Pharmacy Sri Satya Sai University of Technology and Medical Sciences, Sehore, MP, India

Satendra Kumar Saha, College of Pharmacy Sri Satya Sai University of Technology and Medical Sciences, Sehore, MP, India

College of Pharmacy Sri Satya Sai University of Technology and Medical Sciences, Sehore, MP, India

Sunil Kumar Shah, TIT College of Pharmacy, Bhopal, MP, India

TIT College of Pharmacy, Bhopal, MP, India


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Tyagi CK, Saha S, Shah S. Evaluation of anti-ulcer activity of the leaf extract of Solanum pubescens willd. (Solanaceae) in Wistar albino Rats. JDDT [Internet]. 15Sep.2023 [cited 2Oct.2023];13(9):98-06. Available from: https://jddtonline.info/index.php/jddt/article/view/6203