Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder
Chewable tablets of Syzygium cumini seed powder
Aim of this study is to develop chewable tablets of Syzygium cumini seed powder. It has been chosen to do so as there are no oral solid dosage forms of this seed powder developed so far. There are numerous health benefits and nutrient properties of this seed powder, thus it can be used as a nutraceutical. Phytochemical screening of the Syzygium cumini seed powder has been conducted and the various phyto constituents present were detected. Seven different formulations have been developed by direct compression method out of which five were optimized. All these formulations were developed with Syzygium cumini seed powder as the active ingredient and lactose, acacia, glucose, talc, magnesium stearate, hydroxy propyl methyl cellulose, sodium alginate, guar gum and stevia were used as excipients. Various evaluations tests were performed to check the stability of the chewable tablets. Fourier Transform Infrared Spectroscopy (FTIR) analysis was conducted to check the interactions among the seed powder and the excipients. Anti-bacterial activity of the chewable tablets was tested against three different species of bacteria (Escherichia coli and Bacillus subtilis) by agar diffusion method. It is concluded that the Syzygium cumini seed powder and the developed chewable tablets were active against Escherichia coli and Bacillus subtilis.
Keywords: Syzygium cumini, Chewable tablet, anti-bacterial activity
2. Navnidhi Chhikara, R.K., Jaglan S, Sharma P, Gat Y and Panghal A, Bioactive compounds and pharmacological and food applications of Syzygium cumini- a review. Food & Function, 2018(12).
3. Panghal, A., et al., Nutritional, phytochemical, functional and sensorial attributes of Syzygium cumini L. pulp incorporated pasta. Food Chem, 2019; 289:723-728.
4. Gaspar, R.S., et al., Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5. Front Pharmacol, 2019. 10: p. 1678.
5. Rehman A.A., et al., In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits. BMC Complement Altern Med, 2019; 19(1):236.
6. Franca L.M., et al., Syzygium cumini Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats. Oxid Med Cell Longev, 2019; 2019:9417498.
7. Chagas V.T., et al., Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats. Oxid Med Cell Longev, 2018; 2018:5386079.
8. Chaudhary B, K.M., Syzygium cumini (L.) Skeels: A Potential Source of Nutraceuticals. International Journal of Pharmacy and Biological Sciences, 2012; 2(1):46-53.
9. Jadhav VM, S.S.K., V.J.. Kadam, Herbal medicine: Syzygium cumini: A Review. Journal of Pharmacy Research, 2009; 2(7):1212-1219.
10. Dixit S. and Tiwari S, Investigation of anti-diabetic plants used among the ethnic communities of Kanpur division, India. J Ethnopharmacol, 2020; 253:112639.
11. Mandal MD, S.M., and Pal NK, Antibiotic Resistance Prevalence and Pattern in Environmental Bacterial Isolates. The Open Antimicrobial Agents Journal, 2011. 3.
12. Banerjee J, N.R.T., Phytochemical Analyses, Antibacterial, In-vitro Antioxidant and cytotoxic activities of ethanolic extract of SyzygiumCumini (L.) Seed Extract. International Journal of Pharmaceutical Sciences and Research, 2011, 2(7):1799-1806.
13. Chagas V.T., et al., Syzygium cumini (L.) skeels: a prominent source of bioactive molecules against cardiometabolic diseases. Front Pharmacol, 2015; 6:259.
14. Pal AK, Nagaich U, Bharti C, Gulati N, Formulation and Evaluation of Nutraceutical Tablet using Herbal drugs by Direct Compression Method. Journal of Drug Delivery & Therapeutics, 2014; 4(2):47-51.
15. Salome AC, C.U.C.E., lkechukwu VO, Sinye AB, Calister EU, Godswill CO, Formulation and evaluation of Cymbopogon citratus dried leaf-powder tablets. African Journal of Pharmacy and Pharmacology, 2012; 6(48):3274-3279.
16. Bharadwaj Nitin, G.S., Sharma S, Design, development and evaluation of oral herbal formulations of Piper nigrum and Nyctanthes arbortristis. International Journal Of PharmTech Research, 2010; 2(1):171-176.
17. Sumalatha G, J.R.G., Formulation and Evaluation of Polyherbal Chewable Tablets for reducing Nicotine dependence. International Journal of Pharmacy and Biological Sciences, 2017; 7(1):115-120.
18. Damle MC, Bhalekar MR, Rao S, Godse M, Formulation and Evaluation of Chewable Tablets of Pomogranate Peel Extract. Journal of Drug Delivery & Therapeutics, 2019; 9(4):318-321.
19. Bangar Raju, M.B., Indira Bairy, A novel treatment approach towards emerging multidrug resistant Enteroaggregative Escherichia coli (EAEC) causing acute/ persistent diarrhea using medicinal plant extracts. Research Journal of Pharmaceutical, Biological andChemical Sciences, 2011; 2(1):15-23.
20. Siddig A, A.E.A., Elbadawi AA, Mustafa EM, Mussa AA, Structural Characterization and Physical Properties of Syzygium cumini Flowering Plant. International Journal of Innovative Research in Science , Engineering and Technology, 2015; 4(5):2694-2699.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).