Comparative Study of Chitosan and Carboxy Methyl Chitosan Nanoparticles in Mefenamic Acid Drug Delivery
Abstract
Nanoparticle based technologies improve the efficiency and speed of already existing processes.The larger size materials and reagents which are in reactive form, can be nanosized to give efficient output. Chitosan and the carboxy methyl chitosan nanoparticles were prepared by using solvent evaporation nanoprecpitation method, loaded with mefenamic acid, (anthranilic acid derivative) a poorly aqueous soluble drug. Mefenamic acid, if used as conventional dosage form, duration of action was 6 hours; when the drug loaded into Chitosan and the carboxy methyl chitosan nanoparticles the drug release profile was up to 26hrs. The particle size, entrapment efficiency, poly dispersity index, drug loading, drug release profiles of mefenamic acid were compared for both nanoparticles and it was observed that carboxy methyl chitosan nanoparticles released mefenamic acid more effectively than chitosan nanoparticles.
Keywords: Nanoparticles, Chitosan, Carboxy methyl chitosan, Mefenamic acid
Keywords:
Nanoparticles, Chitosan, Mefenamic acid
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References
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35. Chen X, Park H. Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions. Carbohyd. Polym. 2003; 53(4):355-359
2. Jia, ‘Nanoparticle formulation increases oral bioavailability of poorly soluble drugs: Approaches experimental evidences and theory’, Current nanosciences, 2005; 1(3): 237-243
3. Singh R and Lillard JW, ‘Nanoparticle- based targeted drug delivery’, Exp Mol Pathol, 2009; 86(3):215-223
4. Chowdhury A, Kunjiappan S, Pannerselvam T, Somasundaram B and Bhattacharjee Ch, ‘Nanotechnology and nanocarrier- based approaches on treatments of degenerative diseases’, International nano letters, 2017; 7(2): 91-122
5. Kumar V, Sharma N and Maitra SS, ‘In vitro and in vivo toxicity assessment of nanoparticles’, International Nano Letters, 2017; 7(4):243-256
6. Monteiller C, Tran L, MacNee W, Faux S, Jones A, Miller B and Donaldson K “The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area”, Occupational and Environmental Medicine 2007; 64:609-615
7. Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdorster G and Ziesenis A, ‘Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependant but very low’, J Toxicological Environmental Health, 2002; 65(20):1513-30
8. Ray P C, Yu H and Fu P P, “Toxicity and environmental risks of nanomaterials: Challenges and future needs”, J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Jan; 27(1): 1–35
9. Kubota N, Tatsumoto N, Sano T and Toya K, “A simple preparation of half N-acetylated chitosan highly soluble in water and aqueous organic solvents”, Carbohydrate research, 2000; 324(4): 268-274
10. Kurita K, “Controlled Functionalization of the Polysaccharide Chitin,” Progress in Polymer Science, 2001; 26(9):1921-1971
11. Ahmed TA and Aljaeid BM, ‘Preparation , characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery’, Drug design, development and therapy, 2016; 10:483-507
12. Chan JM, Valencia PM, Zhang L, Langer R and Farokhzad OC, ‘Polymeric nanoparticles for drug delivery’, Methods Mol Biol, 2010; 624:163-75
13. Mohammed M A, Syeda J M, Wasan K M and Wasan E K, “An Overview of Chitosan Nanoparticles and its Application in Non-Parental Drug Delivery”, Phrmaceutics,2017; 9(4) :53
14. Bellich B, Agostino ID, Semeraro S, Gamini A and Cesaro A, ‘The good, the bad and the ugly’ of chitosans, Marine drugs, 2016; 14(5):99
15. Yildirimer L, Thanh NTK, Loizidou M, Seifalian AM, ‘Toxicology and clinical potential of nanoparticles’, Nanotoday, 2011; 6(6):587-607
16. Soares S, Sousa J, Pais A and Votorino C, ‘Nanomedicine: principles, properties, and regulatory issues’ Frontiers in Chemistry, 2018; 6:360
17. Mourya VK, Inamdar NN.Chitosan-modifications and applications: opportunities galore. React. Funct. Polym. 2008; 68(6):1013-1051
18. Shariatinia Z, “Carboxy Methyl Chitosan: Properties and Biomedical Applications”, International Journal Of Biological Macromolecules”, 2018; 120 :1406-1419
19. Ali A, Noh N M, Mustafa M A, “Antimicrobial activity of chitosan enriched with lemongrass oil against anthracnose of bell pepper”, Food packaging and shelf life, 2015; 3:56-61
20. Muzarelli R, Tanfani F, Emanuelli M, Pace D P, Chiurazzi E, Piani M, “Sulfated N-(carboxymethyl)chitosans: novel blood anticoagulants”,Carbohydrate research; 1984; 126(2):225-231
21. Muzarelli R, “Carboxy methylated chitins and chitosans”, Carbohydrate Polymers, 1988; 8(1):1-22
22. Muzarelli R, Cucchiara M and Muzarelli C, “N-Carboxymethyl Chitosan in Innovative cosmeceutical products”, J. Appl.Cometol, 2002; 20:201-208
23. Younis N, Shaheen M A and Abdullah M H, “Silymarin-loaded Eudragit RS 100 nanoparticles improved the ability of silyamarin to resolve hepatic fibrosis in bile duct ligated rats”, Biomedicine &Pharmacotherapy, 2016; 81:93-103
24. Reis C P, Neufeld R J, Ribeiro A J and Veiga F, “Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles”, Nanomedicine,2006; 2:8-21
25. Khan I, Saeed K and Khan I, “Nanoparticles: Properties, applications and toxicities”, Arabian journal of chemistry, 2019; 12(7):908-931
26. Vaghani S, Patel M M, Satish C S, Patel K M and Jivani N P, ‘Synthesis and characterization of carboxymethyl chitosan hydrogel: Application as site specific delivery for lercanipidine hydrochloride, Bulletin of Material Sciene, 2012; 35(7):1133-1142
27. Zamani A, Henriksson D and Taherzadeh M J, “A new foaming technique for production of superabsorbents from carboxymethyl chitosan”, Carbohydrate Polymers,2010; 80(4):1091-1101
28. Hu F Q, Wu X L, Du Y Z, You J and Yuan H, “Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin” Eur. J. Pharm. Biopharm. 2008; 69(1):117–125
29. Wang, J.; Xu, M.; Cheng, X.; Kong, M.; Liu, Y.; Feng, C.; Chen, X. Positive/Negative Surface Charge of Chitosan Based Nanogels and Its Potential Influence on Oral Insulin Delivery. Carbohydr. Polym. 2016; 136:867–874
30. Tzaneva D, Simitchiev A, etkova N, Nenov V, stoyanova A and Denev P, “Synthesis of Carboxy Methyl Chitosan and its Rheological Behavior in Pharmaceutical and Cosmetic Emulsions”, Journal of applied Pharmaceutical Science, 2017; 7(10):070-078
31. Chen L, Du Y, Tian Z and Sun L. Effect of the degree of deacetylationand the substitution of carboxymethyl chitosan on its aggregation behavior. J. Polym. Sci. Polym. Phys. 2005; 43:296-305
32. Mourya V, Inamdar N., Tiwari A. Carboxymethyl chitosan and its applications. Advanced Materials Letters 2010; 1(1):11-33
33. Ge H C and Deng K L, “Preparation of carboxymethyl chitosan in aqueous solution under microwave irradiation”, Carbohydrate Research, 2005; 1351-1356
34. Ali Z M, Laghari A J, Ansari A K and Khuhawar M Y, “Synthesis and Characterization of Carboxymethyl Chitosan and its Effect on Turbidity Removal of River Water”, Journal of Applied Chemistry,2013; 5 (3):72-79
35. Chen X, Park H. Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions. Carbohyd. Polym. 2003; 53(4):355-359
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Vedavahini P, Sailu C. Comparative Study of Chitosan and Carboxy Methyl Chitosan Nanoparticles in Mefenamic Acid Drug Delivery. JDDT [Internet]. 15May2020 [cited 18Apr.2024];10(3):83-6. Available from: https://jddtonline.info/index.php/jddt/article/view/3980
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