GC-MS Analysis of Bioactive Compounds and Phytochemical Evaluation of the Ethanolic Extract of Gomphrena globosa L. Flowers

  • Azmat Unnisa Esmat Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001
  • Sirisha Mittapally Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001
  • Safiya Begum Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001

Abstract

Gomphrena globosa (L.) has high medicinal values. All parts are been used as folk medicines. The extract of whole plant / flowers has shown different phytochemical constituents with various clinical properties. These phytochemicals recognised are responsible for various activities such as anti-inflammatory, anticancer, antibacterial, analgesic and cytotoxic. The ethanolic extract of Gomphrena globosa L. flowers of biochemical test indicates the presence of sterols, triterpenoid, tannins, phenols and flavonoids, and on GC-MS analysis it has shown 11 phytochemical compounds with different pharmacological activities. The major bioactive compounds are Docosanoic Acid, Docosyl Ester (25.404%) and Hexatriacontane (24.324%), has proven anti-inflammatory activity.


Keywords: Gomphrena globose L., phytochemical constituents, GC-MS and anti-inflammatory.

Downloads

Download data is not yet available.

Author Biographies

Azmat Unnisa Esmat, Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001

Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001

Sirisha Mittapally, Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001

Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001

Safiya Begum, Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001

Department of pharmaceutics, Deccan School of Pharmacy, Dar-us-salam, Aghapura, Hyderabad, telangana-500001

References

1. Muhammad Ilyas et al., Biological Potential and Phytopharmacological Screening of Gomphrena Species, International Journal of Pharma Research & Review, 2014; 3(1):58-66.
2. Ignacimuthu, S. and M. Ayyanar. Plants used for non-medicinal purposes by the tribal people in kalakad Mundanthurai Tiger reserve, Southern India. Indian Journal Traditional of Knowledge, 2009; 9(3):515-518.
3. Dias, D.A., R.M.X. De Moura, P.S. Pereira, A.H. Januàrio and S.C. França,. Antimicrobial screening and quantitative determination of benzoic acid derivative of Gomphrena celosioides by TLC-Densitometry. Chem. Pharm. Bull. 2004; 52(11):1342-1344.
4. P Yamuna et al. Qualitative phytochemical analysis of Gomphrena globosa Linn. and Gomphrena decumbens Jacq., International Journal of Biology Research, 2017; 2(3):20-22.
5. Krishnaiah D, Sarbatly R, Bono A; Phytochemical antioxidants for health and medicine: A move towards nature. Biotechnol Mol Biol Rev, 2007; 1:97-104.
6. Mahato SB, Sen S. Advances in triterpenoid research, 1990-1994. Phytochemistry. 1997; 44:1185-1236.
7. Herouart D, Sangwan RS, Fliniaux MA, Sangwan-Norreel BS. Variations in the Leaf Alkaloid Content of Androgenic Diploid Plants of Datura innoxia. Planta Med.; 1988; 54:14-17.
8. P Yamuna et al., GC-MS analysis of bioactive compounds in the entire parts of ethanolic extract of Gomphrena globosa Linn., International Journal of Research in Pharmacy and Pharmaceutical Sciences, 2017; 2(4):57-64
9. Khandelwal KR. Chapter 25, Evaluation. In: Practical Pharmacognosy. 12th Edition. Pune: Nirali Prakashan, 2010; 25:1-25.8.
10. Harbone JB. 1973. Phytochemical methods. A guide to modern Techniques of plant Analysis. Chapman and Hall, London, 267-270.
11. Khandelwal KR. Chapter 41, Evaluation. In: Practical Pharmacognosy. 19th Edition. Pune: Nirali Prakashan, 2008:157-158.
12. Raman N. Chapter 5, Qualitative Phytochemical Screening. In: Phytochemical Techniques. New Delhi: New India Publishing agency, 2006: 19-24.
13. P Yamuna et al., Qualitative Phytochemical Analysis of Gomphrena globosa Linn. and Gomphrena decumbens Jacq., International Journal of Biology Research, Volume 2017; 2(3):20-22.
14. Ayesha Siddiqua and Sirisha Mittapally, Formulation and Evaluation of ethanolic extract of Cissus quadrangularis herbal gel, International Research Journal of Pharmaceutical and Biosciences, 2017; 4(4): 9-29.
15. Babu et al., Phytochemical Analysis of Ficus arnottiana (Miq.) Miq. Leaf Extract Using GC-MS Analysis, International Journal of Pharmacognosy and Phytochemical Research; 2017; 9(6):775-779.
16. Dinesh Kumar et al., GC-MS analysis of bioactive compounds from ethanolic leaves extract of Eichhornia crassipes (Mart) Solms. and their pharmacological activities, The Pharma Innovation Journal; 2018; 7(8):459-462.
17. Shubhangi Nagorao Ingole, Phytochemical Analysis of Ficus Religiosa L. (Moraceae) by GC-MS method, International Research Journal of Natural and Applied Sciences, 2017; 4(3):55-63.
18. Sunita Arora and Ganesh Kumar, Phytochemical screening of root, stem and leaves of Cenchrus biflorus Roxb, Journal of Pharmacognosy and Phytochemistry; 2018; 7(1):1445-1450.
19. Pratima Raypa et al., Analysis of Medicinally Important Phytocompounds from Adina cordifolia Leaves, International Journal of Current Microbiology and Applied Sciences; 2018; 7(11):3007-3019
20. Selvan et al., Bioactive compound identification, phytochemical estimation, In-Vitro Anti-Inflammatory and Antioxidant activity of Pupalia Lappacea, International Journal of Pharmacognosy; 2014; 1(9):596-604.
21. Pillai and Nair, GC-MS analysis of chloroform extract of Cleome Burmanni W. and A. (Cleomaceae), International Journal of Pharmaceutical Sciences and Research; 2013; 4(5):1930-1933.
22. Pandurangan A, Khosa RL and Hemalatha S, Anti-inflammatory and analgesic activity of Ichnocarpus frutescens. Pharmacologyonline; 2008; 1:392-399.
23. Sunita Arora and Sonam Meena, GC-MS Profiling of Ceropegia bulbosa Roxb. var.bulbosa, an endangered plant from Thar Desert, Rajasthan, The Pharma Innovation Journal; 2017; 6(11):568-573.
24. Shashikala A. et al., GC-MS analysis of phytocomponents in the methanolic extract of Propolis of Honey Bee, Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry. 2016; 4(2):74-78.
25. Premjanu N, Jayanthy C. Antimicrobial activity of Diethyl Phthalate: An Insilico Approach, Asian Journal of Pharmaceutical and clinical Research, 2014; 7(4):141-142.
26. Ashwathanarayana R and Raja Naika. Anti-Inflammatory properties of Pavetta Crassicaulis Bremek. leaf and flower crude extracts and its pure compounds collected from Western Ghats, Karnataka, India, Asian Journal of Pharmaceutical and Clinical Research, 2018; 11(9):72-90.
27. Balasubramanian et al., GCMS And FTIR analysis on the methanolic extract of Coriandrum Sativum leaves, European Journal of Pharmaceutical and Medical Research, 2018; 5(8):454-460.
28. Aastha Bhardwaj, Najam A. Shakil, Vidyanath Jha, Rajinder Kumar Gupta. “Screening of nutritional, phytochemical, antioxidant and antibacterial activity of underutilized seeds of Scirpus articulatus: the basis of Khubahi Ramdana industry”. Journal of pharmacognosy and phytochemistry; 2014; 3(4):11–20.
Crossmark
Statistics
1284 Views | 1037 Downloads
How to Cite
1.
Esmat AU, Mittapally S, Begum S. GC-MS Analysis of Bioactive Compounds and Phytochemical Evaluation of the Ethanolic Extract of Gomphrena globosa L. Flowers. JDDT [Internet]. 15Mar.2020 [cited 29Mar.2024];10(2):53-8. Available from: https://jddtonline.info/index.php/jddt/article/view/3914