EVALUATION OF ANTIHYPERLIPIDAEMIC EFFECT OF CEDRELA TOONA ROXB. FRUITS
Abstract
Fruit extracts of Cedrela toona Roxb. were evaluated for their antihyperlipidaemic effect in swiss albino female rats. High Cholesterol diet was prepared by mixing cholesterol 2%, sodium cholate 1% and coconut oil 2% or 30 %, with standard powdered standard animal food. The diet was placed in the cage carefully and was aministered for seven days.  Methanol, Chloroform, and Aqueous extracts of Cedrela toona fruits were administered orally at a dose of 250 mg/kg body wt to Hyperlipidaemic rats. After seven days, blood samples were collected from the tail vein after 8 hr fast and allowed to clot for 30 minutes at room temperature. Blood samples were centrifuged at 3000 rpm for 20 minutes. Serum was separated and stored at -20°C until biochemical estimations were carried out. Serum samples were analyzed spectrophotometrically for Cholesterol, triglyceride and HDL-C was estimated using diagnostic kits which were procured from Lab-Care Diagnostics (India) Pvt. Ltd.- Mumbai (India). Results showed that methanolic extract and aqueous extract had  significant effect  in hyperlipidemic rats.
KEYWORDS:Â Cedrela toona, Hyperlipidaemia, Fruit, Cholesterol, Triglyceride.
DOI
https://doi.org/10.22270/jddt.v2i6.334
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