The shelf life study of 0.1 M Sodium hydroxide volumetric solution at different condition for analytical purpose in Laboratory
Abstract
The Expiry date of 0.1 M Sodium hydroxide volumetric solution is determined for analytical purpose in Laboratory and the Strength of Volumetric solutions determined by titration against potassium hydrogen Phthalate (KHP). The volumetric solution prepared in distilled water observed that no chemically significant degradation for at least 30 days when stored separately in Normal and dark condition over a period of 30 days . The % RSD of Molarity at Normal condition observed from 0.0993 to 0.0994 % and at Dark condition from 0.0994 to 0.2988 %. The Significant degradation observed when solution stored separately in oven at 35 oC temperature and strength of volumetric solution deviate from 18 th Day . The Degradation of solution strength found to 0. 98 % after storage for 30 days at 35 oC Temperature.
Keywords: Shelf life, Stability, Titrimetric, Primary standard, Hold time study, Degradation.
DOI
https://doi.org/10.22270/jddt.v9i4-s.3139References
(1) Indian Pharmacopoeia 2007, Volume 1; Volumetric Reagents and Solutions : p.316.
(2) United states Pharmacopoeia 35, NF-30;Test Solutions / Solutions: p.5334.
(3) J.M.F.Nogueira, P.Serodio. Determination of the expiration date of Chemical solutions, Accreditation and Quality Assurance.2003;8(5) :p.231-234.
(4) B.A. Bruer, D.R.G Bruer, C.J.Brien. Shelf life of some common winery laboratory reagents. Am J Enol Vitic.1982; 33(3):p.159-163.
(5) World Health Organization ,WHO Technical Report Series, No. 957, Annex 1, WHO good practices for pharmaceutical quality control laboratories; 2010:p.102-103.
(6) ICH, Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients Guidance for Industry, Laboratory Control Records; September 2016: p.18-19.
Published


How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).