Analytical method development and validation of L-Carnitine L-Tartarate in Pharmaceutical Dosage forms (Multivitamin tablets) using non aqueous titration
Abstract
The Non aqueous titration method was developed for quantitave analysis of L- Carnitine L-Tartarate in multivitamin tablets. The Non aqueous titration method was carried out using 0.1 N Perchloric acids. The present analytical method was validated according to ICH guidelines (ICH,Q2(R1)). The calibration curve was found to linear with correlation coefficient (r2=0.99995), Bias (-0.35) in the range of 50 to 150 % of standard solution. The precision and recovery were determined and all the parameter value found within acceptance limit. The value for both method and intermediate precision were found to 0.57 % and recovery found to 99.11 to 99.59 %. The validation parameter study was method precision, intermediate precision, Linearity and recovery. This is a convenient, precise and rapid accurate method for the estimation of L-Carnitine L-Tartarate in Bulk and Pharmaceutical dosage forms (Multivitamin Tablets).
Keywords: AIDS, Linearity, Correlation coefficient, Bias, Precision and Recovery
DOI
https://doi.org/10.22270/jddt.v9i5.3591Published
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