Preformulation Studies of Intranasal Solid Lipid Nanoparticles of Mometasone Furoate
Abstract
The objective of the present work was to prepare intranasal solid lipid nanoparticles (SLN) of mometasone furoate. Mometasone furoate is BCS class II drug having low aqueous solubility and highly sensitive to hepatic metabolism. Mometasone furoate loaded nanoparticles were prepared by high pressure homogenization technique. The preformulation studied was conducted by studying various selection criteria. Lipid was chosen on the basis of maximum solubility of the drug in lipid. Glyceryl monostearate was selected as the lipid phase which showed maximum drug solubility than other lipids. Selection of surfactant, homogenization pressure and no. of homogenization cycle was done on the basis of minimum particle size and maximum % entrapment efficiency. These results showed high entrapment efficiency and minimum particle size.
Keywords: Intranasal solid lipid nanoparticles, High pressure homogenization, Glyceryl monostearate.
DOI
https://doi.org/10.22270/jddt.v9i4.3100Published
Abstract Display: 1181 
PDF Downloads: 1327 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.