FORMULATION DEVELOPMENT OF SUSTAINED RELEASE EPIDURAL INJECTION OF ANALGESIC DRUG

  • Reshma N Mirajkar, Mrs. AISSMS COLLEGE OF PHARMACY
  • Kalyani Pruthviraj Dhavale AISSMS COLLEGE OF PHARMACY
  • Ashwini R Madgulkar, Dr. AISSMS COLLEGE OF PHARMACY

Abstract

The objective of this work was to formulate and evaluate sustained release epidural injection of analgesic drug diclofenac sodium used in chronic lower back pain. The formulation composed of a thermosensitive polymer Pluronic F127 (20%) and sustained release copolymers HPMC K100M (1%) and HPMC K4M (0.5%) optimized using 32 factorial design. The formulation was found to be clear, colorless, sterile, syringeable through 18gauge, forming a stable gel at 37°C with a gel strength of 9.67g/cm. The drug release was found to be 98.13% in 72 hrs. The formulation was found to be stable at refrigerator temperature of 5°C for a month. Thus, a stable parenteral formulation was developed that can be an appropriate and convenient approach for patients requiring frequent parenteral administration, reducing recurrence of dosage and ultimately expanding patient comfort and satisfaction in case of chronic ailments.

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Author Biographies

Reshma N Mirajkar, Mrs., AISSMS COLLEGE OF PHARMACY

Department of Pharmaceutics, AISSMS College of Pharmacy, Near RTO, Kennedy Road, Pune 411001, Maharashtra, India

Ashwini R Madgulkar, Dr., AISSMS COLLEGE OF PHARMACY

Principal, AISSMS College of Pharmacy, Near RTO, Kennedy Road, Pune 411001, Maharashtra, India

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How to Cite
1.
Mirajkar R, Dhavale K, Madgulkar A. FORMULATION DEVELOPMENT OF SUSTAINED RELEASE EPIDURAL INJECTION OF ANALGESIC DRUG. JDDT [Internet]. 18Aug.2019 [cited 18Jun.2021];9(4-s):540-6. Available from: https://jddtonline.info/index.php/jddt/article/view/3292