ASPECTS RELATED TO THE SOLID LIPID NANOPARTICLES DELIVERY THROUGH THE TOPICAL ROUTE

Abstract

The Solid lipid nanoparticles are the submicrons sized particles which have particle size in the range of 100-1000 nm which can be suitable for skin drug delivery. The Particle size is the major factor influenced at the time of drug delivery, other factor is the physiological acceptable and biodegradable property of the solid lipid nanoparticles. The epidermis i.e. stratum corneum is the rate-limiting factor which requires the appropriate carriers either lipophilic or small particle sized carriers to enhance the penetration. The aspects related while administrating the solid lipid nanoparticles through the skin are the occlusive factor, film formation property of Solid lipid nanoparticles etc. as mechanism. Small particles can make close contact to the Stratum corneum surface i.e. superficial junctions of the corneocytes clusters and furrows between corneocyte islands may favor accumulation for many hours allowing to the sustained release. Solid lipid nanoparticles and Nanostructured lipid carriers should attach as they are for longer and remain at the application site because of a pronounced adhesive effect. However, it is necessary that the adhesiveness is directly proportional to the decrease in the particle size. Water evaporation results in a transition of the lipid matrix to a more highly ordered structure leading to drug expulsion. Improved hydration at least temporarily opens the compact structure of the horny layer, and the permeability of the barrier increases.

KEYWORDS: Solid lipid nanoparticles, Skin, Mechanism of drug penetration through nanocarriers