Design, Formulation and Evaluation of Fast Disintegrating Tablets of Glipizide
Abstract
Diabetes mellitus is metabolic disorder it is caused by an absolute or relative lack of insulin that, among other consequences, to increase in plasma glucose concentration associated with change hyperglycemia and disturbance of lipid metabolism, carbohydrate metabolism, also protein metabolism. Absolute lack of insulin called as Type 1 diabetes mellitus also called as juvenile diabetes. The condition caused by a lesion in the beta cells of the pancreas. Type 2 diabetes is a long term metabolic disorder that characterized by high blood sugar , insulin resistance ,and relative lack of insulin/ The prepared tablets were adequately hard to withstand pressure the hardness ranged from (2.91-3.67). The friability from the tablets was less which represent less loss of free particles. The weight variation and wetting were within limits. The dissolution of prepared tablets was relatively fast.
Keywords: Diabetes mellitus, glipizide, Fast Disintegrating Tablets.
DOI
https://doi.org/10.22270/jddt.v9i3-s.2806Published
Abstract Display: 522 
PDF Downloads: 616 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.