Formulation and evaluation of orodispersible tablets of lornoxicam
Abstract
Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. The purpose of this investigation was to develop mouth dissolving tablets of Lornoxicam using KYRON T-314 (Polacrillin Potassium) as a novel superdisintegrant. Mouth dissolving tablets of lornoxicam were prepared by wet granulation technique using KYRON T-314 as superdisintegrant and menthol as subliming agent. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
Keywords: KYRON T-314, Mouth dissolving tablet, Lornoxicam, Subliming agent, Superdisintegrant
DOI
https://doi.org/10.22270/jddt.v8i6.2058References
Chang R, Guo X, Burnside B, Couch R. A review of fast dissolving tablets. Pharm Tech 2000; 12:52-8.
Bi Y, Sunada H, Yonezawa Y, Danjo K, Iida K. Preparation and evaluation of compressed tablets rapidly disintegrating in the oral cavity. Chem Pharm Bull 1996; 44:2121-7.
Hinz B, Auge D, Rau T, Rietbrock S, Brune K, Werner U. Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography. Biomed Chromatogr 2003; 17:268-75.
Legrand E. Aceclofenac in the management of inflammatory pain. Exp Opin Pharmacother 2004; 5:1347- 57.
Mishra DN, Bindal M, Singh SK, Kumar SG. Spray dried excipient base: A novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull 2006; 54:99-102.
Rowe RC, Sheskey PJ, Owen SC. Handbook of Pharmaceutical Excipients. 5th Ed. Pharmaceutical Press; 2006. p. 532-34.
Fu Y, Jeong SH, Park K. Fast-melting tablets based on highly plastic granules. J Control Release 2005; 109:203-10.
Setty CM, Prasad DVK, Gupta VRM. Development of fast dispersible aceclofenac tablets: Effects of functionality of superdisintegrants. Ind J Pharm Sci 2008; 70(2):180-85.
Omaima AS, Mohammed AH, Nagia AM, Ahmed SZ. Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion. AAPS PharmSciTech 2006; 7:55.
Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS PharmSciTech 2004; 5:36.
Suresh S, Pandit V, Joshi HP. Preparation and evaluation of mouth dissolving tablets of salbutamol sulphate. Ind J Pharm Sci 2007; 69:467-9.
Heinemann H, Rothe W. Preparation of porous tablets. US patent 3885026, 1975.
Knistch A, Hagen E, Munz HD. Production of porous tablets. US patent 4134843, 1979.
Roser BJ, Blair J. Rapidly soluble oral dosage forms, methods of making the same and composition thereof. US patent 5762961, 1998.
Ahmed IS, Fatahalla FA. Pilot study of relative bioavailability of two oral formulations of ketoprofen in healthy subjects, a fast dissolving lyophilized tablet as compared to immediate release tablet. Drug Dev Ind Pharm 2007; 33:505-11.
Ahmed IS, Nafadi MM, Fatahalla FA. Formulation of fast dissolving ketoprofen tablet using freeze-drying in blister technique. Drug Dev Ind Pharm 2006; 32:437-42.
Corveleyn S, Remon JP. Formulation and production of rapidly disintegrating tablets by lyophilization using hydrochlorothiazide as a model drug. Int J Pharm 1997, 152:215-25.
Remon JP, Corveleyn, S. Freeze-dried rapidly disintegrating tablets. US patent 6010719, 2000
Marshall K, Lachman N, Liberman HA. The theory and practice of industrial pharmacy. 3rd Ed. Mumbai, Varghese Publishing House; 1987, p. 66-69.
Yunxia B, Yorinobu Y, Kazumi D, Akinobu O. Preparation and evaluation of oral tablet rapidly dissolving in oral cavity. Chem Pharm Bull 1996; 44(11):2121-27.
Kimura S, Imai T, Otagir M. Pharmaceutical evaluation of Ibuprofen syrup containing low molecular weight gelatin. J Pharm Sci 1992; 81:141-44.
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