Action of Nanosponges in absorption of bacterial toxins
Abstract
Existing detoxification scaffold such as antisera, monoclonal antibodies, small-molecule inhibitors, and molecularly imprinted polymers act by targeting the toxins. Special and specific treatments are required for different diseases. Here we show a biomimetic toxin nanosponge that acts as a toxin decoy in vivo. The nanosponge consists of a polymeric nanoparticle core surrounded by red blood cell membranes. It absorbs membrane-damaging toxins and diverts them away from their cellular targets. Most common toxins in nature, the Pore forming toxins (PFTs), distort cells by forming pores in membranes of the cell and alter their permeability. Apart from their roles in bacterial pathogenesis, PFTs are commonly engaged in venomous attacks by poisonous animals including sea anemones, scorpions, and snakes.
Keywords: Nanosponges, pore forming toxins, absorption.
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