Design development and optimization of immediate release tablet of valsartan
Abstract
The objective of the present study was to prepare immediate release tablets (IRTs) of valsartan by direct compression method. Two types of superdisintegrants i.e. sodium starch glycolate (SSG) and Ac-Di-sol were used in the formulation of tablets. Twelve preliminary trial batches were prepared by varying the concentration of superdisintegrants. It was found that formulation containing Ac-Di-Sol disintegrated in less time as compared to formulation containing sodium starch glycolate. Values of friability was found to be more in case of formulation containing Ac-Di-Sol. Attempts were also made to prepare the tablets containing superdisintegrants in combination and these resulted in the formulation with improved values of disintegration time and friability. On the basis of preliminary studies optimization of IRT was done employing 32 full factorial design using design expert 7. The optimized batch of IRTs showed friability and disintegration time values of 0.82 ± 0.07 and 29 ± 1 respectively. The percent release was also found to be 94.73 ± 4.97% in 5 min.
Keywords: Immediate release tablets, Valsartan, Hypertension, Sodium starch glycolate, Ac-Di-Sol, 32 full factorial design
DOI
https://doi.org/10.22270/jddt.v9i2-s.2444References
Setty CM, Prasad DVK, Gupta VRM, Sa B. Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants. Indian J Pharm Sci. 2008; 70(2):180-184
DRUG Clarke's Analysis of Drugs and Poisons, Third Edition
Rai. V. K., Pathak. N., Bhaskar. R., Nandi. B. C., Dey. S., Tyagi. L. K., Optimization of immediate release tablet of raloxifene hydrochloride by wet granultion method. Int J Pharm Sci Drug Res. 2009 ; (1):51-54
The United States Pharmacopoeia-27/National Formulary-22, 2004, Asian edition. Rockville, MD:US Pharmacopoeial Convention. Inc 2648-2649
Raina B, Sharma A, Bajwa PS. Formulation evaluation and optimization of fast disintegrating tablet of ketorolac tromethamine. Journal of pharmaceutical investigation.2017; 1-1
United State Pharmacopoeia/NF, 38/33 United Pharmacopoeial Convention Inc. Rockville, p 1432
United State Pharmacopoeia/NF, 38/33 United Pharmacopoeial Convention Inc. Rockville, p 483
Jain CP, Naruka PS. Formulation and evaluation of fast dissolving tablets of valsartan. Int J Pharm Pharm Sci. 2009; 1(1):219-26.
United State Pharmacopoeia/NF, 38/33 United Pharmacopoeial Convention Inc. Rockville, p 486
Shrivastava AR, Ursekar B, Kapadia CJ. Design, optimization, preparation and evaluation of dispersion granules of valsartan and formulation into tablets. Current drug delivery. 2009; 6(1):28-37.
Banker GS, Anderson NR. Lachman L, Lieberman HA, Kanig JL (1987) Tablets. The theory and practice of industrial pharmacy, 3rd edn. Varghese Publishing House, Mumbai, p 296
Beringer P, Marderosian AD, Felton L, Gelone S, Gennaro AR, Gupta PK, Hoover JE (2005) Oral solid dosage form, 21st edn. vol 1, The Science and Practice of Pharmacy, Remington, pp 917–918
Published
Abstract Display: 713 
PDF Downloads: 638 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.