Formulation and In-Vitro characterization of glimipride loaded mucoadhesive gelatin microspheres
Abstract
Mucoadhesion is defined as the adhesion of synthetic or biological macromolecules to the biological surface, which can be epithelial tissue or the mucus membrane on the surface of tissue or other parts. The mucoadhesive microspheres of Glimipride were prepared by Emulsion cross linking method using natural polymer Gelatin utilizing temperature change and cross linking agent glutaraldehyde was able to sustain the drug release efficacy. The stability study results shows that the formulation F5 was stable at temperature 40 ± 2˚C/75% RH at the end of 3 months.
The comparative study with the marketed SR formulation results showed that the F5 microsphere formulation had a sustained and prolonged drug release at the end of 24 h than the marketed glimipride SR formulation.
The results of the study revealed that the use of natural polymer Gelatin is an effective strategy for the designing and development of glimipride loaded mucoadhesive microspheres for easy, reproducible and effective oral controlled drug delivery for the treatment of type II Diabetes mellitus.
Keywords: Glimipride, Mucoadhesion, Cross Linking, Gelatin
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